Pituitary Network Association - Disorders

Hypogonadism

Hypogonadism can occur for a number of reasons. Certain men have hypogonadism since birth while others may develop this condition later in life. Two types of hypogonadism are:

Primary hypogonadism (testicular failure) - Low serum testosterone levels and gonadotropins (FSH, LH) above the normal range.

Hypogonadotropic hypogonadism - Idiopathic gonadotropin or LHRH deficiency or pituitary - hypothalamic injury from tumors, trauma, or radiation.

In Men:
Characterized by low serum testosterone levels, but with gonadotropins in the normal or low range. Men develop testicular suppression with decreased libido, impotence, decreased ejaculate volume, loss of body and facial hair, weakness, fatigue and often anemia. On testing, blood levels of testosterone are low and should be replaced. In the United States, testosterone may begiven as a bi-weekly intramuscular injection, a patch form, or a gel preparation. In other countries, oral preparations of testosterone are available.

Symptoms

Impotence
Decreased sexual desire
Fatigue and loss of energy
Mood depression
Regression of secondary sexual characteristics (growth and maturation of prostate, seminal vesicles, penis, and scrotum; the development of male hair distribution, including facial, pubic, chest, axillary hair; laryngeal enlargement; vocal chord thickening; alterations in body musculature; fat distribution)
Osteoporosis

In Women:
Women develop ovarian suppression with irregular periods or absence of periods (amenorrhea), infertility, decreased libido, decreased vaginal secretions, breast atrophy, and osteoporosis. Blood levels of estradiol are low. Estrogen should be replaced and can be given orally as Premarin or Estrace, or can be given as a patch applied twice weekly. Women taking estrogen also need to take progesterone replacement (unless they have undergone a hysterectomy). Annual pap smears and mammograms are mandatory.

Last Revised : August, 2008

Disclaimer: PNA does not engage in the practice of medicine. It is not a medical authority, nor does it claim to have medical knowledge. In all cases, PNA recommends that you consult your own physician regarding any course of treatment or medication.

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