April 2014 Pituitary Research Articles

Knowledge is power and we believe keeping abreast of news on the research front is imperative. Each month in Highlights we feature a few of the top news stories, which you can read below. In addition, we update our website on a regular basis with the latest breaking news related to pituitary and hormonal disorders by gathering stories we think you'll be interested in from MD Linx, Medscape, MedPage Today, PubMed, Touch Endocrinology, News-Medical.net and WebMD.

 

Acromegaly

Patients lost to follow up in acromegaly, results of the acrospect study
European Journal of Endocrinology 03/07/2014

Pituitary Tumors: General

AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling
Oncogene 3/25/14

Endocan, a new invasion and angiogenesis marker of pituitary adenomas
Journal of Neuro-Oncology 02/25/2014

Topographic variations of the optic chiasm and the pituitary stalk: A morphometric study based on midsagittal T2-weighted MR images
Surgical and Radiologic Anatomy 02/27/2014

Cushing's

The challenges in managing giant prolactinomas Review article 

Cushing's Drug Lowers BP, Body Weight
Patients with Cushing's disease treated with the somatostatin analog pasireotide (Signifor) had improvements in multiple manifestations of hypercortisolism, even if urinary free cortisol levels were incompletely controlled, a study found. 

Recent advances in the medical treatment of Cushing's disease.
Fleseriu M.
F1000Prime Rep. 2014 Mar 3;6:18. eCollection 2014. Review.
Editor's note: Dr. Fleseriu is a professional member of the PNA

Widespread reductions of white matter integrity in patients with long-term remission of Cushing's disease
NeuroImage: Clinical 03/05/2014

Clinical, biochemical and imaging characteristics of Cushing's macroadenomas and their long term treatment outcome
Clinical Endocrinology 03/03/2014

Symptomatic Cushing syndrome and hyperandrogenemia revealing steroid cell ovarian neoplasm with late intra-abdominal metastasis 
BMC Endocrine Disorders 02/28/2014

Pituitary Surgery

Limited endoscopic transsphenoidal approach for cavernous sinus biopsy: Illustration of 3 cases and discussion.
Graillon T, Fuentes S, Metellus P, Adetchessi T, Gras R, Dufour H.
Neurochirurgie. 2014 Mar 20. pii: S0028-3770(14)00016-2. doi: 10.1016/j.neuchi.2014.01.004. [Epub ahead of print]

General Pituitary Topics

Pituitary apoplexy syndrome as the manifestation of intracranial tuberculoma.
Verma R, Patil TB, Lalla R.
BMJ Case Rep. 2014 Mar 27;2014. pii: bcr2013201272. doi: 10.1136/bcr-2013-201272.

Decrease in pituitary apparent diffusion coefficient in normal appearing brain correlates with hypopituitarism following traumatic brain injury 
Journal of Endocrinological Investigation 02/26/2014

Growth hormone administration patterns differently regulate epidermal growth factor signaling
Journal of Endocrinology 03/14/2014

The effect of L-thyroxine substitution on lipid profile, glucose homeostasis, inflammation and coagulation in patients with subclinical hypothyroidism
International Journal of Clinical Practice 03/12/2014

Insulin-like growth factor-II: its role in metabolic and endocrine disease
Clinical Endocrinology 03/20/2014

Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors
Journal of Neuro-Oncology 03/04/2014

The Effects of Novel and Newly Approved Antipsychotics on Serum Prolactin Levels: A Comprehensive Review.
Peuskens J, Pani L, Detraux J, De Hert M.
CNS Drugs. 2014 Mar 28. [Epub ahead of print]

Hypopituitarism in a neonate with hyperbilirubinemia and decreased level of consciousness: a case report study.
Mousavi H, Bakhtiyari S.
Acta Med Iran. 2014 Jan;52(1):82-4.

Notch signaling in postnatal pituitary expansion: proliferation, progenitors and cell specification.
Nantie LB, Himes AD, Getz DR, Raetzman LT.
Mol Endocrinol. 2014 Mar 27:me20131425. [Epub ahead of print]

Men's Health

Endo's Testosterone Injection Finally Wins FDA Nod
Testosterone undecanoate for injection (Aveed) has received the FDA's approval for treating male hypogonadism on its third try, its manufacturer announced.

Need More Than Lab Test to Determine Low T
Limitations of current laboratory tests for testosterone deficiency have led to poor reliability that precludes use of any test as the sole basis for diagnosis, authors of a review concluded. 

Group Wants Testosterone Study Retracted
The Androgen Study Group, a large group of physicians and researchers, is calling for the retraction of a paper linking testosterone and cardiovascular risks -- data that its authors are standing firmly behind. 

ADT: No Help as Primary Tx for Prostate Cancer
Primary androgen deprivation therapy (ADT) offered no survival benefit to prostate cancer patients with localized disease who opted not to have surgery or radiation therapy, data from a large retrospective cohort showed.

Women's Health

Menopause Care: Three Experts
What works and what doesn't in menopause care? We tapped three experts in the field for their take. They discussed new follow-up analyses from the Women's Health Initiative, approval of nonhormonal options for hot flashes, and a new treatment for dyspareunia. 

Diabetes, Obesity and Metabolism

Poor Sleep Tied to Metabolic Issues
Substantial observational evidence has tied insufficient sleep to obesity, type 2 diabetes, dyslipidemia, and hypertension, researchers found.

Diabetes in Midlife Shrinks the Brain
Onset of type 2 diabetes in middle age appears to affect late-life cognition by reducing brain volume, MRI studies revealed in a population-based cohort without dementia.

Abbott Continues Glucose Meter Recall
Abbott Diabetes Care is continuing its recall of FreeStyle and FreeStyle Flash blood glucose meters because of the potential for erroneous low blood sugar readings, the company said. 

Small, Frequent Meals Don't Rev Metabolism
Dieters are often told to eat small, frequent meals instead of two or three bigger meals a day to shed extra pounds, but eating this way does not boost metabolism and may increase cardiovascular disease risk, researchers found.

Thyroid

New Thyroid Receptor Binding Site Mapped
Thyroid hormones may bind to a second site not previously reported, located on the surface of the thyroid hormone receptor, researchers found.

Colon Health

Colon Cancer Deaths Decline
The incidence of colon cancer in older adults decreased by 30% in the last decade, coinciding with a tripling of the colonoscopy rate, the American Cancer Society reported.

Home Stool DNA Test Detects Colorectal Tumors
A stool DNA test detected significantly more colon cancers in average-risk patients as compared with a conventional fecal immunochemical test, a large prospective clinical study showed. 

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