Rathkes Cleft Cysts Their Cellular Origins Symptoms and Indications for Surgery

Presented by

Manish Aghi, MD, PhD, MAS

Professor, Neurological Surgery
University of California, San Francisco (UCSF)


Learning Objectives

To understand the cellular origins of Rathke’s Cleft Cysts and what distinguishes them from other cystic masses near the pituitary like craniopharyngiomas

To understand types of symptoms that can arise from Rathke’s Cleft Cysts
To understand indications for surgery for Rathke’s Cleft Cysts

Presenter Bio

Manish Aghi, MD, PhD, is a neurosurgeon-scientist and Professor and Vice Chair of Neurological Surgery at University of California San Francisco (UCSF). As director of the UCSF Center for Minimally Invasive Skull Base Surgery, Dr. Aghi’s neurosurgical practice in the California Center for Pituitary Disorders at UCSF includes the minimally invasive endoscopic endonasal resection of nearly 100 pituitary tumors and tumors of the anterior skull base each year. He has authored over 50 articles and 8 book chapters on pituitary tumors and has edited two books on pituitary tumors. Nationwide, in 2016, he directed a multidisciplinary team of specialists who worked with the Congress of Neurological Surgeons (CNS) to produce evidence-based guidelines on the management of nonfunctional pituitary adenomas. Dr. Aghi also runs an NIH-funded basic science laboratory studying how genetic changes in tumor cells and the cells in their microenvironment contribute to aggressive biology and therapeutic resistance in some brain tumors. The Aghi lab has been awarded multiple research grants from the NIH and private foundations to pursue these studies. Dr. Aghi is also principal investigator of three phase I/II clincial trials using convection-enhanced delivery to deliver chemotherapies directly into brain tumors. Dr. Aghi has served on NIH study sections for reviewing cancer-related grants. Dr. Aghi was recently elected Chair of the American Association of Neurolgoical Surgeons/Congress of Neurological Surgeons Joint Section on Tumors and will serve in that capacity for two years.

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