Research Articles June 2020



Knowledge is power and we believe keeping abreast of news on the research front is imperative. Each month in Highlights we feature a few of the top news stories, which you can read below. In addition, we update our website on a regular basis with the latest breaking news related to pituitary and hormonal disorders by gathering stories we think you'll be interested in from MD Linx, Medscape, MedPage Today, PubMed, Touch Endocrinology, and WebMD.



Treatment of Acromegalic Osteopathy in Real-Life Clinical Practice: The BAAC (Bone Active drugs in ACromegaly) Study.
Mazziotti G, Battista C, Maffezzoni F, Chiloiro S, Ferrante E, Prencipe N, Grasso L, Gatto F, Olivetti R, Arosio M, Barale M, Bianchi A, Cellini M, Chiodini I, De Marinis L, Del Sindaco G, Di Somma C, Ferlin A, Ghigo E, Giampietro A, Grottoli S, Lavezzi E, Mantovani G, Morenghi E, Pivonello R, Porcelli T, Procopio M, Pugliese F, Scillitani A, Lania AG.J Clin Endocrinol Metab. 2020 Jun 8:dgaa363. doi: 10.1210/clinem/dgaa363. Online ahead of print.

Pituitary Tumors

Hypoxia promotes proliferation of pituitary adenomas by HIF-1α/ALKBH5 signaling in vitro.
Qian Y, Zhang C, Wang W, Lu D, Li J, Li L, Li Y, Qiao Y, Song H, Deng X.Int J Clin Exp Pathol. 2020 May 1;13(5):1030-1034. eCollection 2020.

β-arrestin 2 is required for dopamine receptor type 2 inhibitory effects on AKT phosphorylation and cell proliferation in pituitary tumors.
Mangili F, Giardino E, Treppiedi D, Barbieri AM, Catalano R, Locatelli M, Lania AG, Spada A, Arosio M, Mantovani G, Peverelli E.Neuroendocrinology. 2020 Jun 8. doi: 10.1159/000509219. Online ahead of print.

Radiotherapy for the treatment of pituitary adenomas: A dosimetric comparison of three planning techniques.
Ramos-Prudencio R, Pérez-Álvarez SI, Flores-Balcazar CH, de León-Alfaro MA, Herrera-González JA, Elizalde-Cabrera J, Rubalcava-Ortega J, Espinoza-Alvarado L, Balderrama-Ibarra RI.Rep Pract Oncol Radiother. 2020 Jul-Aug;25(4):586-593. doi: 10.1016/j.rpor.2020.04.020. Epub 2020 May

Pituitary miRNAs target GHRHR splice variants to regulate GH synthesis by mediating different intracellular signaling pathways.
Cheng Y, Chen T, Song J, Teng Z, Wang C, Wang S, Lu G, Feng T, Qi Q, Xi Q, Liu S, Hao L, Zhang Y.RNA Biol. 2020 Jun 8. doi: 10.1080/15476286.2020.1778295. Online ahead of print.

Empty Sella Syndrome

Partial empty sella syndrome, GH deficiency and transient central adrenal insufficiency in a patient with NF1.
Kyritsi EM, Hasiotou M, Kanaka-Gantenbein C.Endocrine. 2020 Jun 9. doi: 10.1007/s12020-020-02351-z. Online ahead of print.

Hormonal Health

Androgen-dependent sexual dimorphism in pituitary tryptophan hydroxylase expression: relevance to sex differences in pituitary hormones.
Kawabata-Sakata Y, Nishiike Y, Fleming T, Kikuchi Y, Okubo K.Proc Biol Sci. 2020 Jun 10;287(1928):20200713. doi: 10.1098/rspb.2020.0713. Epub 2020 Jun 10.

Endocrine vigilance in COVID-19.
Velayoudom FL, Alwis Wijewickrama PS, Ranathunga HI, Somasundaram N.J Pak Med Assoc. 2020 May;70(Suppl 3)(5):S83-S86. doi: 10.5455/JPMA.16.

What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience.
Sharma SR, Gonda X, Dome P, Tarazi FI.Pharmacol Ther. 2020 Jun 5:107602. doi: 10.1016/j.pharmthera.2020.107602. Online ahead of print.

Genetic Evaluation of Patients With Delayed Puberty and Congenital Hypogonadotropic Hypogonadism: Is it Worthy of Consideration?
Festa A, Umano GR, Miraglia Del Giudice E, Grandone A.Front Endocrinol (Lausanne). 2020 May 19;11:253. doi: 10.3389/fendo.2020.00253. eCollection 2020.

Pituitary and Aging

Effects of Exercise on Cognitive Performance in Older Adults: A Narrative Review of the Evidence, Possible Biological Mechanisms, and Recommendations for Exercise Prescription.
Quigley A, MacKay-Lyons M, Eskes G.J Aging Res. 2020 May 14;2020:1407896. doi: 10.1155/2020/1407896. eCollection 2020.