Comparative effectiveness of therapies for graves’ hyperthyroidism: a systematic review and network meta-analysis

Journal of Clinical Endocrinology and Metabolism, 07/05/2013

Sundaresh V et al. – The primary outcome was to determine the relapse rates of various treatment options. The secondary outcome was to present data regarding adverse effects of antithyroid drugs (ATDs). The authors confirm the relatively high relapse rate of ATD therapy in comparison with radioactive iodine (RAI) or surgery, along with a significant side–effect profile for these drugs. These data can inform discussion between physician and patients regarding choice of therapy for Graves' disease (GD). The limited quality of the evidence in the literature underlines the need for future RCTs in this area.