Comparison of primary somatostatin analogue therapy and pituitary adenomectomy on survival in patients with acromegaly: a retrospective cohort study

European Journal of Endocrinology, 07/08/2013

Bogazzi F et al. – The objective of the study was to compare the effect of different therapies for acromegaly on mortality. Therapies of acromegaly and comorbidities have lowered mortality to the level of the general population; SSA alone or following pituitary adenomectomy was comparable to curative neurosurgery on survival in non–diabetic patients; on the contrary, SSA as primary therapy, may be less effective than adenomectomy in reducing mortality in diabetic patients.