Differential effects of growth hormone and growth hormone-releasing peptide-6 on astrocytes

Journal of Endocrinology, 06/24/2013

Baquedano E et al. – Growth hormone and growth hormone secretagogues are involved in many cellular activities such as stimulation of mitosis, proliferation and differentiation. Since astrocytes are involved in developmental and protective functions, the aim was to analyse the effects of growth hormone and growth hormone–releasing hexapeptide on astrocyte proliferation and differentiation in the hypothalamus and hippocampus. The authors conclude that although growth hormone–releasing hexapeptide is a growth hormone secretagogue, it may exert growth hormone independent effects centrally on astrocytes when administered iv although the effects of both substances appear to be mediated by the PI3K/Akt pathway.