Increased long-term remission after adequate medical cortisol suppression therapy as presurgical treatment in Cushing's disease
Clinical Endocrinology, 07/12/2013
van den Bosch OFC et al. – In the last decade, preoperative medical cortisol suppression therapy has frequently been used in Cushing's disease to normalize cortisol concentrations preoperatively. The aim was to assess the efficacy of presurgical medical cortisol suppression therapy in Cushing's disease. Adequate presurgical cortisol suppression treatment with ketoconazole or metyrapone in Cushing's disease seems to be associated with suppressed postoperative cortisol concentrations and an increased long–term remission rate.