January 2014 Pituitary Research Articles


Knowledge is power and we believe keeping abreast of news on the research front is imperative. Each month in Highlights we feature a few of the top news stories, which you can read below. In addition, we update our website on a regular basis with the latest breaking news related to pituitary and hormonal disorders by gathering stories we think you'll be interested in from MD Linx, Medscape, MedPage Today, PubMed, Touch Endocrinology, News-Medical.net and WebMD.


MedPage Today

OTC Thyroid 'Boosters' May Harm
Patients who take over-the-counter supplements that promise to enhance thyroid function may get more than they bargained for, endocrinologists warn.

Antidepressant Dressed Up for Menopause

Striking a Nerve: $100M in Gov't Funds for Mental Health
The Obama administration said it had allocated $100 million in new funding for community mental health and substance abuse treatment programs, but can that make a difference? Striking a Nerve is a blog by John Gever for readers interested in psychiatry and neurology.

Pay and Practice: Mental Health Reform Gets Lost
Although you may not have heard about it, a clinical psychologist in Congress has released his proposal to reform the nation's mental health system. Pay and Practice is a blog by David Pittman for readers with an interest in health policy.

Body Building Drugs Threaten Public Health
Abuse of performance-enhancing drugs isn't just a problem of top athletes -- it's a large-scale public health problem that affects some 3 million people who use them in the U.S., according to a new scientific statement from The Endocrine Society.


Changing perspectives in screening for congenital hypothyroidism and congenital adrenal hyperplasia
This review explains the uptick in incidence rate of congenital hypothyroidism and underscores issues in management that can affect developmental outcome. One specimen two–tier testing for CAH resulted in an increased false negative rate without significantly reducing the false positive rate. The benefit of collecting second specimens for CAH screening is problematic. Optimal treatment of CAH continues to pose a challenge.

Surveillance strategy for rectal neuroendocrine tumors according to recurrence risk stratification
Digestive Diseases and Sciences, 12/24/2013 Clinical Article

Early promising results for the endoscopic surgical treatment of Cushing's disease
Endoscopic approach in the treatment of Cushing's disease is clearly better for patients because of its low morbidity rates and short duration of hospital stay. On the other hand, long–term follow–up of the patients will show whether these favorable observations will persist.

Genetic analyses of bone morphogenetic protein 2, 4 and 7 in congenital combined pituitary hormone deficiency
A mutation in the BMP4 coding region resulting in an amino acid exchange (p.Arg300Pro) appeared most interesting among the identified variants.

Impulse control disorders in patients with dopamine agonist-treated prolactinomas and non-functioning pituitary adenomas: a case-control study
Clinical Endocrinology, 11/28/2013
Until prospective studies on the relationship of DA use in prolactinoma patients and ICDs are available, the authors propose that prolactinoma patients be forewarned of possible ICD development with DA therapy.

The current role of transcranial surgery in the management of pituitary adenomas
Pituitary, 11/12/2013
Pratheesh R, et al. – The aim of this study was to determine the factors influencing the use of a transcranial (TC) approach in pituitary adenomas and suggest a decision–making tree for the surgical strategy. A study of the preoperative MRI for factors that predict difficulty with the TS approach might encourage the surgeon to consider a TC surgery either as an initial approach or combined with a TS surgery.


The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature.
Pease M, Ling C, Mack WJ, Wang K, Zada G.
PLoS One. 2013 Dec 18;8(12):e82619. doi: 10.1371/journal.pone.0082619.

The AIP (aryl hydrocarbon receptor-interacting protein) gene and its relation to the pathogenesis of pituitary adenomas.
Lloyd C, Grossman A.
Endocrine. 2013 Dec 24. [Epub ahead of print]

Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth.
Yang Y, Sheng M, Huang F, Bu D, Liu X, Yao Y, Dai C, Sun B, Zhu J, Jiao Y, Wei Z, Zhu H, Lu L, Zhao Y, Jiang C, Wang R.
Pituitary. 2013 Dec 31. [Epub ahead of print]

Transsphenoidal pituitary surgery in the elderly is safe and effective.
Pereira EA, Plaha P, Chari A, Paranathala M, Haslam N, Rogers A, Korevaar T, Tran D, Olarinde R, Karavitaki N, Grossman AB, Cudlip SA.
Br J Neurosurg. 2013 Dec 30. [Epub ahead of print]

Reconstructed bone chip detachment is a risk factor for sinusitis after transsphenoidal surgery.
Hsu YW, Ho CY, Yen YS.
Laryngoscope. 2014 Jan;124(1):57-61. doi: 10.1002/lary.23964. Epub 2013 Oct 15.

Analysis of regulatory networks constructed based on gene coexpression in pituitary adenoma.
Gong J, Diao B, Yao GJ, Liu Y, Xu GZ.
J Genet. 2013 Dec;92(3):489-97.

Recommended Articles

Insurer will pay for 12-year-old's Gastric Bypass after Craniopharyngioma
A 12-year-old girl from Texas who had surgery for a craniopharyngioma 2 years ago has just received word that her insurance company (which is affiliated with the military) will approve a second surgery, this time to lose weight. Her doctors told NBC that the girl developed hypothalamic obesity and hyperphagia as a side effect from the surgery and has gained 140 pounds. Strangers have raised $78,000 for the little girl, which will now be used to cover medical expenses not covered by insurance. The girls' mother says any extra monies will be donated to help other children with similar issues.
Read more here.

New Labels for Testosterone Gel
The FDA has ordered changes to the labeling for certain testosterone gels in order to emphasize safety for women and children who may come in contact with the products.
Read a release from the FDA here. Read an analysis from a legal website here.

Did Goliath Have Acromegaly?
The Los Angeles Times published an opinion piece that criticizes a recent book called "David and Goliath," by author Malcolm Gladwell. The book suggested that the biblical giant (Goliath) probably had acromegaly. The op-ed writer (a Yale professor) says that we don't have enough evidence to make that conclusion.
Read the column athttp://articles.latimes.com/2013/oct/31/opinion/la-oe-badenmoss-gladwell-goliath-20131031


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