March 2014 Pituitary Research Articles

Knowledge is power and we believe keeping abreast of news on the research front is imperative. Each month in Highlights we feature a few of the top news stories, which you can read below. In addition, we update our website on a regular basis with the latest breaking news related to pituitary and hormonal disorders by gathering stories we think you'll be interested in from MD Linx, Medscape, MedPage Today, PubMed, Touch Endocrinology, and WebMD.


MedPage Today

Exercise Cuts Stroke Risk From Hormone Therapy CME
Exercise may moderately shave off some of the increased risk of hormone therapy, researchers found. 

Secondary Thyroid Tumors More Deadly
Thyroid tumors that develop following an earlier malignancy are more deadly for young people than primary thyroid tumors, researchers reported. 

Hot Topics: Advances in Thyroid Care

What works and what doesn't in thyroid care? We tapped four experts in the field for their take. They discuss new small-molecule drugs, increasing diagnosis, screening, and radioactive iodine therapy. 

Hot Topics: Advances in Menopause Care

What works and what doesn't in menopause care? We tapped three experts in the field for their take. They discussed new follow-up analyses from the Women's Health Initiative, approval of nonhormonal options for hot flashes, and a new treatment for dyspareunia. 

Hot Topics: Advances in Obesity Treatment

What works and what doesn't in obesity treatment? We asked four experts in the field for their views. They discussed new targeted drug therapies, hormonal pathways, and drug cocktails. 

Pay and Practice: FDA Launches Safe Drugs Pilot

WASHINGTON -- The FDA said Tuesday that it is launching a pilot program that will allow quicker entry for drugs coming from certain foreign exporters, freeing the agency to focus on catching adulterated or unapproved drugs. 

Oxytocin Undoes Menopausal Weight Gain, Bone Loss CME

A daily dose of oxytocin reversed osteopenia and visceral fat gain in a mouse model of menopause, researchers reported. 

Obesity: Studies Find Genes Drive Appetite CME

Genetic differences in how infants respond to food may play a role in obesity risk, according to two studies. 

Removing Ovaries Puts Bones and Carotids at Risk

Oophorectomy prior to menopause was associated with a greater risk for carotid artery thickening and bone loss more than a decade post-menopause, researchers found. 

Hot Topics: Homing In on Better Therapy for Colon Cancer

Advances in tumor gene analysis have helped lead the way toward more effective and more efficient treatment of colorectal cancer. 

Mental Health: Parity Yes, Providers No

Demand -- for both facilities and providers -- has long outpaced supply in the field of mental health, but recent moves to increase funding for mental health services combined with innovative delivery systems may reverse that trend. 

MD Linx

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome
New England Journal of Medicine, 02/28/2014
Hypothyroidism and risk of mild cognitive impairment in elderly persons a population-based study
JAMA Neurology, 02/12/2014 Clinical Article
The study aims to evaluate the association of clinical and subclinical hypothyroidism with mild cognitive impairment (MCI) in a large population–based cohort. In this population–based cohort of elderly people, neither clinical nor subclinical hypothyroidism was associated with MCI.


Editor's note: Dr. Manish Aghi is an esteemed member of the PNA.
Tumors of the anterior skull base.
Ivan ME, J Han S, Aghi MK.
Expert Rev Neurother. 2014 Feb 25. [Epub ahead of print]

Patient-reported nasal morbidity following endoscopic endonasal skull base surgery.
Gallagher MJ, Durnford AJ, Wahab SS, Nair S, Rokade A, Mathad N.
Br J Neurosurg. 2014 Feb 24. [Epub ahead of print]

Central hypothyroidism in adults: better understanding for better care.
Grunenwald S, Caron P.
Pituitary. 2014 Feb 20. [Epub ahead of print]

Thyrotropin-secreting pituitary adenomas: outcome of pituitary surgery and irradiation.
Malchiodi E, Profka E, Ferrante E, Sala E, Verrua E, Campi I, Lania AG, Arosio M, Locatelli M, Mortini P, Losa M, Motti E, Beck-Peccoz P, Spada A, Mantovani G.
J Clin Endocrinol Metab. 2014 Feb 19:jc20134376. [Epub ahead of print]

Symptomatic Rathke's cleft cyst with a co-existing pituitary tumor; Brief review of the literature.
Babu R, Back AG, Komisarow JM, Owens TR, Cummings TJ, Britz GW.
Asian J Neurosurg. 2013 Oct;8(4):183-7. doi: 10.4103/1793-5482.125662.

CDK5 and Its Activator P35 in Normal Pituitary and in Pituitary Adenomas: Relationship to VEGF Expression.
Xie W, Wang H, He Y, Li D, Gong L, Zhang Y.
Int J Biol Sci. 2014 Jan 25;10(2):192-9. doi: 10.7150/ijbs.7770. eCollection 2014.

Estradiol, but not Testosterone, Heightens Cortisol-Mediated Negative Feedback on Pulsatile ACTH Secretion and ACTH Approximate Entropy.
Sharma AN, Aoun P, Wigham JR, Weist SM, Veldhuis JD.
Am J Physiol Regul Integr Comp Physiol. 2014 Feb 26. [Epub ahead of print]

Autophagy in the endocrine glands.
Weckman A, Di Ieva A, Rotondo F, Syro LV, Ortiz LD, Kovacs K, Cusimano MD.
J Mol Endocrinol. 2014 Feb 24;52(2):R151-63. doi: 10.1530/JME-13-0241. Print 2014.

TIDAL WAVES: Network mechanisms in the neuroendocrine control of prolactin release.
Lyons DJ, Broberger C.
Front Neuroendocrinol. 2014 Feb 18. pii: S0091-3022(14)00020-X. doi: 10.1016/j.yfrne.2014.02.001. [Epub ahead of print] Review.



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