PNA Medical Corner: Incipient Gigantism


This month the PNA Medical Corner highlights an article co-authored by Dr. Albert Beckers, a longtime member of the PNA. The study looks at the case of a 7-year-old boy with a pituitary tumor due to a gene mutation. They conclude that not all tumors of this type respond to pasireotide.
AACE Clin Case Rep
. 2021 Dec 16;8(3):119-123.
doi: 10.1016/j.aace.2021.12.003. eCollection May-Jun 2022.

Complicated Clinical Course in Incipient Gigantism Due to Treatment-resistant Aryl Hydrocarbon Receptor-Interacting Protein-mutated Pediatric Somatotropinoma

• PMID: 35602875 PMCID: PMC9123570 DOI: 10.1016/j.aace.2021.12.003


Background: Our objective was to describe the clinical course and treatment challenges in a very young patient with a pituitary adenoma due to a novel aryl hydrocarbon receptor-interacting protein (AIP) gene mutation, highlighting the limitations of somatostatin receptor immunohistochemistry to predict clinical responses to somatostatin analogs in acromegaly.

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PNA Spotlight: Dr. Adam Mamelak


adam mamelakThis month the PNA Spotlight focuses on Dr. Adam Mamelak, a neurosurgeon and co-director of the Pituitary Center at Cedars Sinai Medical Center in Los Angeles. Dr. Mamelak earned his B.A. in Physics at Tuft University and earned his MD from Harvard Medical School. He did a surgical internship and then a residency at the University of California at San Francisco Medical Center. He did a fellowship at the Epilepsy Research Laboratory at UCSF, and another postdoctoral fellowship in neuroscience at the California Institute of Technology & Huntington Medical Research Institutes in Pasadena, California. Dr. Mamelak was kind enough to answer a series of questions from the PNA. His answers follow.

What inspired you to choose your career path?

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May 2022 Research Articles

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PNA Medical Corner: Quality of Life for Acromegalics


ursula kaiserkevin yuenThis month the PNA Medical Corner focuses on an article co-authored by two members of the PNA, Drs. Kevin Yuen and Ursula Kaiser. The study compared the quality of life for groups of acromegaly patients; one that received pharmacological therapy, the other that did not. They conclude that acromegalics who develop growth hormone deficiency have lower quality of life. They found that while pharmacologic or radiotherapy don’t lower a person’s quality of life, their overall quality of life is suboptimal despite biochemical control.

Pituitary. 2022 Apr 27.
doi: 10.1007/s11102-022-01224-0. Online ahead of print.

PMID: 35476257 DOI: 10.1007/s11102-022-01224-0

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