PATHFNDR

 

 

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Investigational Studies to Evaluate the Safety and Efficacy of Paltusotine in Patients with Acromegaly 

The PATHFNDR studies are recruiting patients to participate in clinical research for once-daily paltusotine for the treatment of acromegaly. If the studies are successful, paltusotine could be approved as a ONCE-DAILY, ORAL treatment option that gives patients an alternative to injections or twice-daily oral medications. 
 
 As a study participant, you could play an important role in advancing the options available for acromegaly treatment for yourself and many others living with this rare disease. 
 
ABOUT THE STUDIES 
 
The purpose of the PATHFNDR studies is to see if Crinetics Pharmaceutical's investigational medication, paltusotine, is safe and effective in patients with acromegaly. 
 
PATHFNDR-1 is a randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine in
 subjects with acromegaly treated with somatostatin receptor ligand (SRL) based treatment regimens.  Clinicaltrials.gov 
 
PATHFNDR-2 is a randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine in
 subjects with non-pharmacologically treated acromegaly. Clinicaltrials.gov 
 
 
1(855) 848-8486

 

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July 2022 Research Articles

 

Acromegaly

IGF-I variability over repeated measures in patients with acromegaly under long-acting somatostatin receptor ligands.

Pituitary Surgery

The Clinical Relevance of the Thalamogeniculate Arteries in Endoscopic Endonasal Surgery for Giant Pituitary Adenomas in the Interpeduncular Fossa.  Editor’s note: Dr. Prevedello is a longtime member of the PNA.

The effects of the application of the "disease-characteristics nursing quality improvement" programme to nursing practice for patients after the resection of pituitary adenomas using the endonasal transsphenoidal approach.

Arachnoid Remodeling by Clipping Technique Facilitates Surgical Maneuverability during Transsphenoidal Surgery for Pituitary Macroadenoma.

Remote extradural hematoma as a complication of endoscopic transsphenoidal surgery: A case report with literature review.

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PNA Spotlight: Dr. Andre Beer Furlan

 

furlanThis month the PNA Spotlight focuses on Dr. Andre Beer Furlan, a skull base and endovascular neurosurgeon at Moffitt Cancer Center and Assistant Professor of Oncologic Sciences at the University of South Florida. Dr. Beer Furlan got his medical degree and a PhD from the University of São Paulo in Brazil. He stayed at the University of São Paulo to complete a neurosurgery residency. He practiced as a neurosurgeon and skull base surgeon in Sao Paulo and then moved to the United States, where he did a second neurosurgery residency at Rush University. He also did fellowships in skull base micro-neurosurgery at Weill Cornell Medical College, minimally invasive cranial surgery at Ohio State University and neuro-endovascular surgery at Rush University. He is fluent in English, Portuguese, Spanish and Italian. Dr. Beer Furlan was kind enough to answer a series of questions from the PNA; here are his answers.

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Medical Corner: Adult Growth Hormone Deficiency

 

fleseriublevinskevin yuenThis month the PNA Medical Corner features an article co-authored by multiple members of the PNA, including Drs. Kevin Yuen, Lewis Blevins and Maria Fleseriu. The co-authors have developed an algorithm that combs a database and predicts which people would benefit from further testing to see if they have Adult Growth Hormone Deficiency.

Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database

• PMID: 35761982

• DOI: 10.1155/2022/7853786

Abstract

Objective: Adult growth hormone deficiency (AGHD) is an underdiagnosed disease associated with increased morbidity and mortality. Identifying people who may benefit from growth hormone (GH) therapy can be challenging, as many AGHD symptoms resemble those of aging. We developed an algorithm to potentially help providers stratify people by their likelihood of having AGHD.

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June 2022 Research Articles

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PNA Medical Corner: Incipient Gigantism

 

This month the PNA Medical Corner highlights an article co-authored by Dr. Albert Beckers, a longtime member of the PNA. The study looks at the case of a 7-year-old boy with a pituitary tumor due to a gene mutation. They conclude that not all tumors of this type respond to pasireotide.
AACE Clin Case Rep
. 2021 Dec 16;8(3):119-123.
doi: 10.1016/j.aace.2021.12.003. eCollection May-Jun 2022.

Complicated Clinical Course in Incipient Gigantism Due to Treatment-resistant Aryl Hydrocarbon Receptor-Interacting Protein-mutated Pediatric Somatotropinoma

• PMID: 35602875 PMCID: PMC9123570 DOI: 10.1016/j.aace.2021.12.003

Abstract

Background: Our objective was to describe the clinical course and treatment challenges in a very young patient with a pituitary adenoma due to a novel aryl hydrocarbon receptor-interacting protein (AIP) gene mutation, highlighting the limitations of somatostatin receptor immunohistochemistry to predict clinical responses to somatostatin analogs in acromegaly.

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PNA Spotlight: Dr. Adam Mamelak

 

adam mamelakThis month the PNA Spotlight focuses on Dr. Adam Mamelak, a neurosurgeon and co-director of the Pituitary Center at Cedars Sinai Medical Center in Los Angeles. Dr. Mamelak earned his B.A. in Physics at Tuft University and earned his MD from Harvard Medical School. He did a surgical internship and then a residency at the University of California at San Francisco Medical Center. He did a fellowship at the Epilepsy Research Laboratory at UCSF, and another postdoctoral fellowship in neuroscience at the California Institute of Technology & Huntington Medical Research Institutes in Pasadena, California. Dr. Mamelak was kind enough to answer a series of questions from the PNA. His answers follow.

What inspired you to choose your career path?

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May 2022 Research Articles

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