PNA Medical Corner: Cushing's and Osilodrostat

 

fleseriuThis month the PNA Medical Corner features an article co-authored by a longtime member of the PNA, Dr. Maria Fleseriu, a Professor of Endocrinology and Neurological Surgery and Director of the Pituitary Center at Oregon Health & Science University. The study looks the the use of the drug osilodrostat for treatment of Cushing’s Syndrome and makes recommendations on best practices.

Treatment of Cushing's syndrome with osilodrostat: practical applications of recent studies with case examples
Maria Fleseriu , Beverly M K Biller 
Affiliations expand

• PMID: 36002784 PMCID: PMC9401199 DOI: 10.1007/s11102-022-01268-2

Abstract

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PNA Spotlight: Dr. Edward Laws

 

edward lawsThis month the PNA Spotlight focuses on Dr. Edward R Laws, MD, FACS, a Professor of Neurosurgery at Brigham and Women's Hospital (MGB) in Boston/Harvard Medical School.  He also serves as Director of the Pituitary/Neuroendocrine Center in the Department of Neurosurgery at Brigham and Women’s Hospital in Boston, Massachusetts. Boston, Massachusetts.  Dr. Laws was kind enough to send us a letter about his career in the field of pituitary neurosurgery, which we reprint here in its entirety.  Dr. Laws has been an integral part of the PNA since the beginning 30 years ago. We are grateful for his friendship and service.

My medical career began in 1959 as a first-year student at the Johns Hopkins School of Medicine. Among all of the new information and coursework, I quickly developed an interest in the anatomy, pathology, and physiology of the brain, and that interest never went away! In 1960, I was fortunate to have a great mentor for research on the nervous system, giving me a launching point for expanding my research interests to pituitary surgery and endocrinology, which has fully lasted as my favorite topic and source of effort.

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Spotlight: Dr. Fernandez-Miranda

 

fernandez mirandaThis month the PNA Spotlight focuses on Dr. Juan Carlos Fernandez-Miranda, a Professor of Neurosurgery and the Surgical Director of Brain Tumor, Skull Base and Pituitary Centers at Stanford University. Dr. Fernandez-Miranda did a neurosurgery residency at La Paz University Hospital in Madrid, Spain. He completed a fellowship in microsurgical neuroanatomy at the University of Florida. He did clinical training in cerebrovascular surgery at the University of Virginia, and in endoscopic endonasal and open skull base surgery at University of Pittsburgh Medical Center (UPMC). He joined the faculty at Stanford earlier this year. He was kind enough to answer some questions from the PNA. His answers are below:

What inspired you to choose your career path?

When I was a young kid, about 10-11 years old, I got sick with a skin rash and high fever; the family doctor visited our home, carefully examined me, and based on a number of clues, he determined I got a very rare bacterial infection known as scarlet fever; a few days of antibiotic medication and I was back to normal. I now realized that I was fascinated by the wisdom, expertise, and detective attitude of the physician, and this personal event was (I now know) key to my future decision to become a doctor.

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August 2022 Research Articles

 

Pituitary Surgery

Free Tissue Transfer for Skull Base Osteoradionecrosis: A Novel Approach in the Endoscopic Era

Editor’s note: Dr. Kshettry is a member of the PNA.

Minimally invasive keyhole techniques for resection of giant intracranial tumors.

Risk factors for delayed postoperative hyponatremia in patients with non-functioning pituitary adenomas undergoing transsphenoidal surgery: A single-institution study.

Pituitary and COVID-19

Encephalitis due to COVID-19 in a Patient Who Has Undergone Transsphenoidal Pituitary Surgery.

Pituitary Apoplexy

Revisiting Pituitary Apoplexy.

Pituitary Tumors/Morphology

Extra-pituitary midline structural abnormalities associated with ectopic posterior pituitary detected on a new rapid MRI protocol (FAST1.2).

Ultra-High-Field 7 T Magnetic Resonance Imaging Including Dynamic and Static Contrast-Enhanced T1-Weighted Imaging Improves Detection of Secreting Pituitary Microadenomas.

Hormonal Health

Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression.

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