Spotlight: Dr. Fernandez-Miranda


fernandez mirandaThis month the PNA Spotlight focuses on Dr. Juan Carlos Fernandez-Miranda, a Professor of Neurosurgery and the Surgical Director of Brain Tumor, Skull Base and Pituitary Centers at Stanford University. Dr. Fernandez-Miranda did a neurosurgery residency at La Paz University Hospital in Madrid, Spain. He completed a fellowship in microsurgical neuroanatomy at the University of Florida. He did clinical training in cerebrovascular surgery at the University of Virginia, and in endoscopic endonasal and open skull base surgery at University of Pittsburgh Medical Center (UPMC). He joined the faculty at Stanford earlier this year. He was kind enough to answer some questions from the PNA. His answers are below:

What inspired you to choose your career path?

When I was a young kid, about 10-11 years old, I got sick with a skin rash and high fever; the family doctor visited our home, carefully examined me, and based on a number of clues, he determined I got a very rare bacterial infection known as scarlet fever; a few days of antibiotic medication and I was back to normal. I now realized that I was fascinated by the wisdom, expertise, and detective attitude of the physician, and this personal event was (I now know) key to my future decision to become a doctor.

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August 2022 Research Articles


Pituitary Surgery

Free Tissue Transfer for Skull Base Osteoradionecrosis: A Novel Approach in the Endoscopic Era

Editor’s note: Dr. Kshettry is a member of the PNA.

Minimally invasive keyhole techniques for resection of giant intracranial tumors.

Risk factors for delayed postoperative hyponatremia in patients with non-functioning pituitary adenomas undergoing transsphenoidal surgery: A single-institution study.

Pituitary and COVID-19

Encephalitis due to COVID-19 in a Patient Who Has Undergone Transsphenoidal Pituitary Surgery.

Pituitary Apoplexy

Revisiting Pituitary Apoplexy.

Pituitary Tumors/Morphology

Extra-pituitary midline structural abnormalities associated with ectopic posterior pituitary detected on a new rapid MRI protocol (FAST1.2).

Ultra-High-Field 7 T Magnetic Resonance Imaging Including Dynamic and Static Contrast-Enhanced T1-Weighted Imaging Improves Detection of Secreting Pituitary Microadenomas.

Hormonal Health

Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression.

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News Articles August 2022


Chinese Cancer Researchers Study Pituitary Hormone Receptors

The Journal Science reports that researchers with the University of Science and Technology of China “have made a breakthrough in the treatment of cancer through immunotherapy, identifying a particular hormone receptor as a potential target for the treatment.” The receptor promotes tumor growth. It is called MC5R and works with the pituitary hormone α-MSH which is produced by the pituitary gland. Read More:

Son Grows Hair, Makes a Wig for Mom with Pituitary Tumor

shahaThe Today Show’s website has the story of a man in Arizona who grew out his hair for two years in order to make a wig for his mother, who suffers from a recurring pituitary tumor. Read more:

Caption: Melanie and Matt Shaha (Courtesy Shaha family.)

Study: Signifor Reduces Tumors in Cushings

An article in Cushing’s Disease News looks at research that found that SignifActor With Acromegaly Passes Away In Los Angelesor reduced tumor size in 40% of Cushing’s patients in the study, but most of them had already had surgery. Read more:

Symptoms of a Brain Tumor

An article in VeryWellHealth lists the common signs of a brain tumor: “vomiting, seizures, balance problems, dizziness, personality changes, loss of consciousness, and more.”
Read more:

Well-Known Egyptian Acromegalic Dies at Age 27

The PNA sends its condolences to the family of Huda Abdel-Gawad, a 27-year-old acromegalic who passed away recently from kidney failure. Abdel-Gawad had come to be known as Egypt’s tallest woman. Read more:

Actor With Acromegaly Passes Away In Los Angeles

irwin keyesCharacter actor Irwin Keyes passed away recently at age 63 from complications of acromegaly. He was known for his roles in “House of 1000 Corpses”, “The Jeffersons” and “Intolerable Cruelty”.

Caption: Actor and acromegalic Irwin Keyes. (Wikimedia Commons)


Medical Corner: Can Prolactin Protect You?


vatesThis month the PNA Medical Corner spotlights an article co-authored by PNA member G. Edward Vates, a professor of neurosurgery at the University of Rochester. The study finds that a moderately high level of prolactin (but not excessively high level) seems to protect retinal function in patients with a tumor squeezing the optic chiasm.


Prolactin at moderately increased levels confers a neuroprotective effect in non-secreting pituitary macroadenomas.

Affiliations expand

• PMID: 35921360 PMCID: PMC9348739 DOI: 10.1371/journal.pone.0271690


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Investigational Studies to Evaluate the Safety and Efficacy of Paltusotine in Patients with Acromegaly 

The PATHFNDR studies are recruiting patients to participate in clinical research for once-daily paltusotine for the treatment of acromegaly. If the studies are successful, paltusotine could be approved as a ONCE-DAILY, ORAL treatment option that gives patients an alternative to injections or twice-daily oral medications. 
 As a study participant, you could play an important role in advancing the options available for acromegaly treatment for yourself and many others living with this rare disease. 
The purpose of the PATHFNDR studies is to see if Crinetics Pharmaceutical's investigational medication, paltusotine, is safe and effective in patients with acromegaly. 
PATHFNDR-1 is a randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine in
 subjects with acromegaly treated with somatostatin receptor ligand (SRL) based treatment regimens. 
PATHFNDR-2 is a randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine in
 subjects with non-pharmacologically treated acromegaly. 
1(855) 848-8486



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