Two Companies Partner to Pursue New Therapeutic for Acromegaly

by Suzanne Potter

abribatThe French pharmaceutical company Amolyt Pharma and the Japanese company PeptiDream recently announced they will team up to develop therapeutic peptides for the treatment of acromegaly.

 Amolyt, based in Lyon and in Boston, has experience in this field. Currently they have a program in development for hypoparathyroidism that has recently received orphan drug status from the U.S. Food and Drug Administration. Amolyt is also working on a second peptide for glucose and fat metabolism, which is in the preclinical stage.

PeptiDream, based in Kanagawa, is a large company with teams of peptide chemists that is partnering Amolyt to move their discovery forward.

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January 2021 Research Articles

 

Pituitary Tumors

JAG1, Regulated by microRNA-424-3p, Involved in Tumorigenesis and Epithelial-Mesenchymal Transition of High Proliferative Potential-Pituitary Adenomas.

Differential macroscopic and histologic features between pituitary adenomas presenting with and without presurgical anterior pituitary dysfunction. A study of 232 patients.

Ayurvedic Management of Hyperprolactinemia Secondary to Pituitary Microadenoma: A Case Report.

Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells.

Pituitary Surgery

Delayed Postoperative Hyponatremia Following Endoscopic Transsphenoidal Surgery for Non-Adenomatous Parasellar Tumors.

Acromegaly

Risk factors and management of pasireotide-associated hyperglycemia in acromegaly.
Editor’s note; Drs. Fleseriu, van der Lely and Colao are all members of the PNA.

Rathke’s Cleft Cyst

Rathke's cleft cyst infections and pituitary abscesses: case series and review of the literature.

Cushing’s

Assessment of non-traumatic vertebral fractures in Cushing's syndrome patients.

Spinal epidural lipomatosis: a rare association of Cushing's disease.

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January 2021

 

Patient Story: Finishing College Despite a Pituitary Tumor

okajimaIn an article from the Orange Coast News, 23-year-old food blogger Justine Okajima recounts how she discovered her pituitary tumor, got treatment and even finished college, earning an M.F.A.in Dance with a minor in hospitality management from Cal State University Long Beach.  Read more:

Photo courtesy Justine Okajima/Facebook

 

 

11-year-old with Craniopharyngioma “Joins” UCLA Volleyball Team

matthew ignacioAn article in the Daily Bruin tells the story of 11-year-old Matthew Ignacio from Pico Rivera, CA who is battling a craniopharyngioma. Through a program called Team Impact, he has signed a letter of intent to “join” the UCLA (University of California at Los Angeles) men’s volleyball team, and has bonded with the athletes through music and video games. Read more:

Photo credit: Daily Bruin

 

Boy with Craniopharyngioma Raises Money for Charity

luke webberAn article in the Comet tells the story of a young teenager named Luke Webber from the U-K who is raising money for s children’s brain tumor charity called Anna’s Home, after undergoing surgery for a craniopharyngioma. He has raised more than 7,600 pounds  ($6,833) so far. Read more here: 

Photo courtesy Hayley Warner

 

 

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Dr. Nelson Oyesiku Named Chair Neurology at UNC School of Medicine

 

oyesikuThe PNA would like to congratulate longtime PNA member Nelson M. Oyesiku, MD, PhD, FACS, on his appointment as Chair of the University of North Carolina School of Medicine Department of Neurosurgery. He has served for many years as co-director of the Emory Pituitary Center and is the editor-in-chief of the journals Neurosurgery, Operative Neurosurgery and Neurosurgery Open. Read more here:

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PNA Spotlight: Dr. Tyler Kenning

 

kenningThe PNA Spotlight focuses this month on Tyler Kenning MD, FAANS, director of pituitary and cranial base surgery at the Piedmont Brain Tumor Center at Piedmont Atlanta Hospital. Dr. Kenning studied medicine at Jefferson Medical College and did an internship and residency at Albany Medical Center. He went on to complete a fellowship in neurosurgical oncology and cranial base surgery at Thomas Jefferson University Hospital. Dr. Kenning was kind enough to answer a series of questions from the PNA; his answers follow.

• What inspired you to choose your career path?

My father was a neurosurgeon. Growing up, I watched him work tirelessly, and I quickly realized that his efforts truly embodied the virtues of Theodore Roosevelt’s sentiment that “...the best prize that life has to offer is the chance to work hard at work worth doing.” The potential ability to make a meaningful difference in patients’ lives led me to similarly pursue a career in medicine and then neurosurgery. During my training, I became greatly interested in the physiology of the pituitary gland and the endocrine system as well as endoscopic ‘minimally invasive’ neurosurgery. The prospect of having a brain tumor and then undergoing a neurosurgical procedure is a very daunting and scary one for patients, and the ability to offer ‘minimally invasive’ but ‘maximally effective’ surgery to treat these problems is important.

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