The greatest of follies is to sacrifice health for any other kind of happiness.

-Arthur Schopenhauer

 

PNA Spotlight: Dr. Adriana G. Ioachimescu

This month the PNA Spotlight focuses on Adriana G. Ioachimescu, MD, PhD, FACE Professor of Medicine (Division of Endocrinology and Molecular Medicine) and Neurosurgery at the Medical College of Wisconsin, a lifetime professional member of the PNA.
Dr. Ioachimescu was a Professor of Medicine in Endocrinology and Neurosurgery at the Emory University School of Medicine. Dr. Ioachimescu was also co-director and co-founder of the Emory Neuroendocrine Pituitary Center and a consulting editor at Endocrinology and Metabolism Clinics. Previously she worked at Carol Davila University in Bucharest, Romania, and at the Cleveland Clinic.

Dr. Ioachimescu was born in Bucharest, Romania and earned her PhD in Neuroendocrinology from Carol Davila University of Medicine. She completed an internship in internal medicine at Danbury Hospital and then a fellowship in Endocrinology at the Cleveland Clinic. She did residencies in internal medicine at Carol Davila University, Yale University and the Cleveland Clinic.

Dr. Ioachimescu was kind enough to respond to a few questions from the PNA:

PNA Medical Corner: Machine Learning and Pituitary Surgery

An article co-authored by multiple members of the PNA (Including Drs. Samson, Chaichana, and Quinones-Hinojosa) looks at the role of machine learning in forecasting outcomes of pituitary surgery. They conclude that it is not ready yet as no model achieved clinical applicability.

https://pubmed.ncbi.nlm.nih.gov/36979305/

Abstract

Background: The complex nature and heterogeneity involving pituitary surgery results have increased interest in machine learning (ML) applications for prediction of outcomes over the last decade. This study aims to systematically review the characteristics of ML models involving pituitary surgery outcome prediction and assess their reporting quality.

Methods: We searched the PubMed, Scopus, and Web of Knowledge databases for publications on the use of ML to predict pituitary surgery outcomes.

Featured News and Updates

News Articles October 2025

News Articles October 2025

When Cushing’s becomes cancer: metastasis or induced by radiation?

An article in Cushing’s Disease News looks at a study that examines the case of two women whose benign tumors associated with Cushing’s disease turned malignant.  The question is whether they metastasized or if radiation could have induced the transformation.  More info: https://cushingsdiseasenews.com/news/cushings-pituitary-tumors-rarely-aggressive-cancers/

Pituitary apoplexy: symptomatic vs asymptomatic

A study in the Journal of Clinical Neuroscience looks at the clinical profile of patients with and without symptoms of pituitary apoplexy.  Symptoms include “headache, vomiting and cranial nerve palsies.”  People without symptoms who suffered pituitary apoplexy had lower white blood cell counts and lower blood sodium levels. Read more: https://www.sciencedirect.com/science/article/abs/pii/S0967586825005983

When a pituitary macroadenoma causes sepsis-like symptoms

A study on Cureus.com presents a case report where a woman was initially treated for sepsis but turned out to have a pituitary macroadenoma.  Read more: https://assets.cureus.com/uploads/case_report/pdf/413034/20250912-112610-bm0ldk.pdf

 Acute Sheehan’s Syndrome after post-partum pituitary hemorrhage

A case study presented on Cureus.com looks at the patient who gave birth, suffered a pituitary hemorrhage, and developed acute Sheehan’s Syndome and then pituitary atrophy eight months postpartum. Read more: https://assets.cureus.com/uploads/case_report/pdf/411201/20250914-401650-bm0ldk.pdf

 

Research Articles

October 2025 Research Articles

Pituitary tumors


A new and useful tool for differentiating prolactinomas from non-functioning pituitary adenomas: a pilot study of the cabergoline disconnection test.

Galliano SA, Stumpf MAM, Queiroz NL, Ferreira EHR, Craveiro FL, Gruetzmacher C, Silva GOD, Cescato VAS, Vellutini EAS, Cunha-Neto MBC, Batista RL, Glezer A.Einstein (Sao Paulo). 2025 Sep 15;23:eAO1694. doi: 10.31744/einstein_journal/2025AO1694. eCollection 2025.

 

The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors.

Pugazenthi S, Pari SS, Zhang Z, Silverstein J, Kim AH, Patel B.Front Med (Lausanne). 2025 Sep 1;12:1629621. doi: 10.3389/fmed.2025.1629621. eCollection 2025.

 

Limitations of MRI in differentiating solid and cystic components of craniopharyngiomas.

Karaalioğlu B, Öksüz NÇ, İpek V, Çakır A, Kahraman O, Özbek MA.Childs Nerv Syst. 2025 Sep 16;41(1):281. doi: 10.1007/s00381-025-06941-y.


Idiopathic Arginine Vasopressin Deficiency With an Incidental Non-functional Pituitary Microadenoma in an Elderly Diabetic Woman.

Krishna MSV, Babu DVSP, Singh M, Madhavan S.Cureus. 2025 Aug 13;17(8):e89995. doi: 10.7759/cureus.89995. eCollection 2025 Aug.

 

Cushing’s Disease


Changing face of Cushing’s disease over three decades in pituitary center.

Muradov I, Sahin S, Uysal S, Sulu C, Gunebakan P, Tunc A, Kocaman BB, Soltanova L, Gazioglu N, Tanriover N, Kadioglu P.J Endocrinol Invest. 2025 Sep 16. doi: 10.1007/s40618-025-02702-5. Online ahead of print.

Editor’s note:  Dr. Gazioglu is a member of the PNA.


Update on Medical Treatment of Cushing’s Syndrome.

Dillon BR, Agrawal N, Schwarz Y, Dancel-Manning K, Tabarin A, Lacroix A, Hofland LJ, Feelders RA.Drugs. 2025 Sep 15. doi: 10.1007/s40265-025-02223-8. Online ahead of print.

 

Acromegaly

Metabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross-Sectional Study in China.

Tagilapalli SK, Wang Z, Lu YL, Zhang G, Su W, Wu Z, Wang J, Rao Q, Wang H, He D, Mou Y, Yao S, Tie Y, Chen W.CNS Neurosci Ther. 2025 Sep;31(9):e70607. doi: 10.1111/cns.70607.

 

Imaging

Trade-Off Analysis of Classical Machine Learning and Deep Learning Models for Robust Brain Tumor Detection: Benchmark Study.

Tian Y.JMIR AI. 2025 Sep 15;4:e76344. doi: 10.2196/76344.

 

Hormonal health


Idiopathic hyperprolactinemia-associated hypogonadism in men presenting with normal testosterone levels.

Cheng X, Xiao Y, Deng Y, Chen Q, Wen X, Zhou E, Zhou H.PLoS One. 2025 Sep 18;20(9):e0332871. doi: 10.1371/journal.pone.0332871. eCollection 2025.

 

Evaluation of thyrotrophic and lactotrophic reserves in patients with pituitary dwarfism with and without empty sella turcica.

Geremia C, Geremia F.J Pediatr Endocrinol Metab. 2025 Jul 21;38(9):904-914. doi: 10.1515/jpem-2025-0082. Print 2025 Sep 25.

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