The greatest of follies is to sacrifice health for any other kind of happiness.

-Arthur Schopenhauer

 

PNA Spotlight: Dr. Adriana G. Ioachimescu

This month the PNA Spotlight focuses on Adriana G. Ioachimescu, MD, PhD, FACE Professor of Medicine (Division of Endocrinology and Molecular Medicine) and Neurosurgery at the Medical College of Wisconsin, a lifetime professional member of the PNA.
Dr. Ioachimescu was a Professor of Medicine in Endocrinology and Neurosurgery at the Emory University School of Medicine. Dr. Ioachimescu was also co-director and co-founder of the Emory Neuroendocrine Pituitary Center and a consulting editor at Endocrinology and Metabolism Clinics. Previously she worked at Carol Davila University in Bucharest, Romania, and at the Cleveland Clinic.

Dr. Ioachimescu was born in Bucharest, Romania and earned her PhD in Neuroendocrinology from Carol Davila University of Medicine. She completed an internship in internal medicine at Danbury Hospital and then a fellowship in Endocrinology at the Cleveland Clinic. She did residencies in internal medicine at Carol Davila University, Yale University and the Cleveland Clinic.

Dr. Ioachimescu was kind enough to respond to a few questions from the PNA:

PNA Medical Corner: Machine Learning and Pituitary Surgery

An article co-authored by multiple members of the PNA (Including Drs. Samson, Chaichana, and Quinones-Hinojosa) looks at the role of machine learning in forecasting outcomes of pituitary surgery. They conclude that it is not ready yet as no model achieved clinical applicability.

https://pubmed.ncbi.nlm.nih.gov/36979305/

Abstract

Background: The complex nature and heterogeneity involving pituitary surgery results have increased interest in machine learning (ML) applications for prediction of outcomes over the last decade. This study aims to systematically review the characteristics of ML models involving pituitary surgery outcome prediction and assess their reporting quality.

Methods: We searched the PubMed, Scopus, and Web of Knowledge databases for publications on the use of ML to predict pituitary surgery outcomes.

Featured News and Updates

News Articles June 2025

News Articles June 2025

New imaging tool to diagnose Cushing’s?

An article in Cushing’s Disease News looks at a study that find that a new form of PET scan, alongside a CT  scans can detect tumors that produce ACTH, common in Cushing’s disease. Read more:

https://cushingsdiseasenews.com/news/imaging-technique-found-accurately-id-cushings-pituitary-tumors/

Exercise and hormonal health

An article in mindbodygreen.com examines the effect of exercise on your hormones. Read more: https://www.mindbodygreen.com/articles/how-high-intensity-exercise-impacts-cortisol-and-other-hormones

Pituitary patient describes afterlife following near-death experience

A story on MSN.com relates the experiences of Brianna Lafferty, a pituitary patient who was clinically dead for 8 minutes. She now works as a transition guide. Read more here:

https://www.msn.com/en-us/health/medical/woman-who-died-for-8-minutes-claims-death-is-an-illusion-as-she-recalls-afterlife/ar-AA1FuWo5

Research Articles

June 2025 Research Articles

Pituitary Tumors

Effect of antineoplastic drug therapies on carcinoma and aggressive pituitary tumors: a systematic review and meta-analysis.

Cardoso ABR, Zimmermann AC, Raverot G, Nunes-Nogueira VDS.Pituitary. 2025 Jun 2;28(3):70. doi: 10.1007/s11102-025-01541-0.

Impulse control disorders in pituitary adenoma: What do we know and what we still don’t know in almost two decades?

Kadioglu P, Glezer A.Pituitary. 2025 Jun 2;28(3):71. doi: 10.1007/s11102-025-01533-0.

Effect of antineoplastic drug therapies on carcinoma and aggressive pituitary tumors: a systematic review and meta-analysis.

Cardoso ABR, Zimmermann AC, Raverot G, Nunes-Nogueira VDS.Pituitary. 2025 Jun 2;28(3):70. doi: 10.1007/s11102-025-01541-0. 

Impulse control disorders in pituitary adenoma: What do we know and what we still don’t know in almost two decades?

Kadioglu P, Glezer A.Pituitary. 2025 Jun 2;28(3):71. doi: 10.1007/s11102-025-01533-0.

Clinico-pathological and molecular characteristics of pediatric-juvenile pituitary neuroendocrine tumors (PitNETs): A mono-institutional series.

Buccoliero AM, Giunti L, Ponticelli A, Innocenti L, Ricci F, Cetica V, Tirinnanzi B, Moscardi S, Stagi S, Sardi I, Mussa F, Genitori L, Scagnet M.Clin Neuropathol. 2025 Jun 2. doi: 10.5414/NP301685. Online ahead of print.

Pituitary Surgery


Use of a Septal Stapler to Secure a Septal Free Mucosal Graft to the Nasoseptal Flap Donor Site Following Endoscopic Endonasal Resection of a Pituitary Adenoma.

Miller JE, Fischer JL, Wang MB.J Neurol Surg Rep. 2025 Apr 23;86(2):e98. doi: 10.1055/a-2531-6140. eCollection 2025 Apr.

Hormonal health

The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial.

Atila C, Camerin SJ, Liechti ME, Christ-Crain M.Endocr Connect. 2025 Jun 1:EC-25-0254. doi: 10.1530/EC-25-0254. Online ahead of print.

Combined pituitary hormone deficiency with a novel GLI2 frameshift variant.

Matsuo Y, Adachi N, Mukai T, Kato S, Kato M, Tanaka H.Pediatr Int. 2025 Jan-Dec;67(1):e70082. doi: 10.1111/ped.70082.PMID: 40457737 No abstract available.

Effect of pubertal induction with combined gonadotropin therapy on testes development and spermatogenesis in males with gonadotropin deficiency: a cohort study.

Castro S, Ng Yin K, d’Aniello F, Alexander EC, Connolly E, Hughes C, Martin L, Prasad R, Storr HL, Willemsen RH, Dunkel L, Butler G, Howard SR.Hum Reprod Open. 2025 May 13;2025(2):hoaf026. doi: 10.1093/hropen/hoaf026. eCollection 2025.

Long-term pituitary function following transsphenoidal surgery for non-functional pituitary neuroendocrine tumor with apoplexy: a single-center retrospective analysis.

Zou D, Yang Y, Gao R, Ou Y, Luo J, Zhang Z, Yang T, Cheng J.Sci Rep. 2025 Jun 1;15(1):19226. doi: 10.1038/s41598-025-03053-0.

Safety and efficacy of endoscopic vs. microscopic approaches in pituitary adenoma surgery: A systematic review and meta-analysis.

Al-Dardery NM, Khaity A, Soliman Y, Ali MOM, Zedan EM, Muyasarah K, Elfakhrany MD.Neurosurg Rev. 2025 Jun 1;48(1):471. doi: 10.1007/s10143-025-03600-3.

 

Hormonal Health

The effect of MDMA on anterior pituitary hormones: a secondary analysis of a randomized placebo-controlled trial.

Atila C, Camerin SJ, Liechti ME, Christ-Crain M.Endocr Connect. 2025 Jun 1:EC-25-0254. doi: 10.1530/EC-25-0254. Online ahead of print.

Combined pituitary hormone deficiency with a novel GLI2 frameshift variant.

Matsuo Y, Adachi N, Mukai T, Kato S, Kato M, Tanaka H.Pediatr Int. 2025 Jan-Dec;67(1):e70082. doi: 10.1111/ped.70082.

 

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