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Giving Tuesday

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PNA Exclusives

Advanced Technologies in Pituitary Surgery: The Role of VR, AR, and AI in Achieving Better Outcomes.

Presented by: Dr. Robert Louis

See previous webinars in the video carousel below

PNA Spotlight: Dr. Manish Aghi

manish aghi

Dr. Manish Aghi is a neurosurgeon and scientist at University of California, San Francisco (UCSF). He completed his MD-PhD degrees through the MSTP program at Harvard Medical School, followed by neurological surgery residency and postdoctoral training at Massachusetts General Hospital. He is currently faculty in the department of neurological surgery and graduate division of biomedical sciences, as well as a principal investigator in the Brain Tumor Research Center at UCSF. As director of the UCSF Center for Minimally Invasive Skull Base Surgery, Dr. Aghi’s neurosurgical practice in the California Center for Pituitary Disorders at UCSF includes the minimally-invasive endoscopic endonasal resection of over 100 pituitary tumors and tumors of the anterior skull base each year.  


Mario Zuccarello, MD

This month the PNA Spotlight focuses on Dr. Mario Zuccarello, Professor of Neurosurgery and Director of the Brain Tumor Center at the University of Cincinnati Gardner Neuroscience Institute.  Dr. Zuccarello earned his M.D. and did his residency at the University of Padova, Italy. He then completed three fellowships at the University of Iowa at Iowa City, the University of Virginia Medical Center at Charlottesville and the University of Cincinnati Medical Center.  He was kind enough to answer some questions from PNA staff; his answers follow.

What inspired you to choose your career path?

Early experiences with my father’s illness gave me my first exposure to medicine. As I started medical school, I became deeply interested in the anatomy and physiology of the brain. This led to my discovery of neuroscience and to the realization that the best way I could get to know brain function was to become a neurosurgeon. After I became a neurosurgery resident, I understood that neurosurgery required my entire dedication and commitment. I was fortunate to learn from mentors who taught me the importance of knowledge of surgical neuroanatomy in order to perform accurate, safe surgeries. I still have the pleasure of learning and perfecting new surgical techniques and continue to carry this message to my trainees.

What is the primary focus of your work/research?

My primary clinical focus is the treatment of patients with pituitary tumors, skull base tumors, and complex cerebrovascular disease. My clinical practice also includes a full range of minimally invasive approaches, in addition to complex open skull base and brain surgery.
My research interests involve the study of surgical neuroanatomy and the application of innovative techniques in the operating room with the goal of improving surgical safety and effectiveness. I am particularly interested in the development of keyhole approaches, and the use of the endoscope during those procedures to improve surgical exposure, decrease morbidity, decrease hospital stay, and to improve outcomes.

What do you consider to be the future of your field?

The field of pituitary tumor management is the perfect example of how the future medicine will be. A multidisciplinary approach with the creation of Centers of Excellence will provide a comprehensive assessment and the selection of the best and most effective medical and/or surgical treatment. Because the use of current endoscopes, including 3D endoscopes, has decreased surgical invasiveness and improved effectiveness, I am sure that in the future we will have better visualization tools which will make surgery even better. In addition, I am confident that in the future higher-quality images will be capable of identifying ever smaller tumors, and more effective medical treatments will become available.

What should patients know about your field/what deserves more recognition/awareness?

The treatment of patients with pituitary tumors requires a team-based approach. Patients must find the best team, one that offers all treatment modalities to treat their disease. All members of the team: neurosurgeon, endocrinologist, ENT, neuro-ophthalmologist, radiation therapist, neuroradiologist, and neuropathologist play a very important role. All members must be committed to collaboration, in order to achieve the best outcome.

What would you like to convey about yourself to your patients?

Patients, and in particular neurosurgical patients, put their life in our hands. I have dedicated my life to becoming the best possible surgeon for my patients. I am committed to provide my patients with the best and most compassionate care, to provide all the information needed to make the decisions that are best for them.

Why did you get involved with the PNA and what is the extent of your involvement?

The PNA provides a knowledgeable and highly reliable resource to educate patients and family members about pituitary adenomas. I want to make my contribution to PNA so that our patients can continue to receive proper, updated education and counseling.


weill cornell ny presbyterian

Please find attached the information about two clinical trials available at WCM. These trials have a novel, selective cortisol receptor blocker for the treatment of ectopic, pituitary, and adrenal Cushing syndrome with overt hypercortisolism (GRACE study). As well as a milder adrenal Cushing SD, where just 1mg Dex test needs to be abnormal (GRADIENT study).

These are phase 3 trials. Also, we have the extension phase for GRACE and are working on getting to our site the extension for GRADIENT study. This will permit patients to utilize the drug beyond the clinical trial, till it becomes available in the market.


Pituitary Network Association

The PNA is an international non-profit organization for patients with pituitary tumors and disorders, their families, loved ones, and the physicians and health care providers who treat them.

The PNA was founded in 1992 by a group of acromegalic patients in order to communicate and share their experiences and concerns. The PNA has rapidly grown to become the world's largest and fastest growing patient advocacy organization devoted to the treatment and cure of pituitary disorders.

You Can Help! 

Donate Today

The PNA is supported by an international network of the world's finest physicians and surgeons. Our goal is to reach every patient who may be forgotten, abandoned, or worse yet, undiagnosed after many years of suffering. We are doing this in three ways: (1) by providing public awareness programs and educational seminars, (2) by assisting the medical community in developing uniform standards for early diagnosis, surgery, radiation, pharmacological treatment and follow-up, and (3) by having interactive websites and a referral program on these websites.

Mission Statement

To support, pursue, encourage, promote and where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.