The greatest of follies is to sacrifice health for any other kind of happiness.

-Arthur Schopenhauer

 

PNA Spotlight: Dr. Adriana G. Ioachimescu

This month the PNA Spotlight focuses on Adriana G. Ioachimescu, MD, PhD, FACE Professor of Medicine (Division of Endocrinology and Molecular Medicine) and Neurosurgery at the Medical College of Wisconsin, a lifetime professional member of the PNA.
Dr. Ioachimescu was a Professor of Medicine in Endocrinology and Neurosurgery at the Emory University School of Medicine. Dr. Ioachimescu was also co-director and co-founder of the Emory Neuroendocrine Pituitary Center and a consulting editor at Endocrinology and Metabolism Clinics. Previously she worked at Carol Davila University in Bucharest, Romania, and at the Cleveland Clinic.

Dr. Ioachimescu was born in Bucharest, Romania and earned her PhD in Neuroendocrinology from Carol Davila University of Medicine. She completed an internship in internal medicine at Danbury Hospital and then a fellowship in Endocrinology at the Cleveland Clinic. She did residencies in internal medicine at Carol Davila University, Yale University and the Cleveland Clinic.

Dr. Ioachimescu was kind enough to respond to a few questions from the PNA:

PNA Medical Corner: Machine Learning and Pituitary Surgery

An article co-authored by multiple members of the PNA (Including Drs. Samson, Chaichana, and Quinones-Hinojosa) looks at the role of machine learning in forecasting outcomes of pituitary surgery. They conclude that it is not ready yet as no model achieved clinical applicability.

https://pubmed.ncbi.nlm.nih.gov/36979305/

Abstract

Background: The complex nature and heterogeneity involving pituitary surgery results have increased interest in machine learning (ML) applications for prediction of outcomes over the last decade. This study aims to systematically review the characteristics of ML models involving pituitary surgery outcome prediction and assess their reporting quality.

Methods: We searched the PubMed, Scopus, and Web of Knowledge databases for publications on the use of ML to predict pituitary surgery outcomes.

Featured News and Updates

News Articles July 2026

Infant diagnosed with pituitary tumor

Doctors in the U.K. diagnosed a 4-month-old baby boy with a pituitary tumor and performed surgery to remove it. Read more: https://uk.news.yahoo.com/bradford-baby-diagnosed-brain-tumour-020000577.html

Pituitary journey: Soccer superstar Lionel Messi

A doctor in the U.K. well-known for his internet explainer videos explains on the case of soccer star Lionel Messi, who was diagnosed with growth hormone deficiency as a child and underwent years of growth hormone injections. His family paid for the medical care at first but then Team Barcelona agreed to cover the cost of his treatment in Spain.  See the YouTube video here: https://www.youtube.com/watch?v=Liovxj7D0H4

Pituitary journey: from patient to future neurosurgeon

An article on The Good Things Guy website looks at the pituitary journey of Cadi de Jager, a 19-year-old woman in South Africa who was diagnosed at age nine with a Rathke’s Cleft cyst. She underwent two surgeries and is now in college with the goal of becoming a pediatric neurosurgeon. Read more: https://www.goodthingsguy.com/cadi-de-jager-conquered-brain-tumour/

Sprained ankle leads to Cushing’s diagnosis

A teen in Brazil with a sprained ankle went to the ER – where alert doctors decided to test him for Cushing’s disease after hearing about his sudden weight gain, headaches and high blood pressure. Read more:  https://en.clickpetroleoegas.com.br/teens-weight-gain-and-cushings-disease-revealed-by-ankle-injury-doctors-discover-tiny-pituitary-tumor-in-113-kilo-brazilian-adolescent-vacs75/#goog_rewarded

Research Articles

Research Articles July 2026

Pituitary tumors

Pituitary adenoma-associated with Schopf-Schulz-Passarge syndrome.

Brady RT, Allinson K, René C.BMJ Case Rep. 2026 Jun 26;19(6):e267144. doi: 10.1136/bcr-2025-267144.

 

Immune and clinicopathological features of molecularly defined prolactinoma subtypes.

Wang DP, Liu YT, Dai YT, Chen S, Cheng YJ, Lin SJ, Zhang Y, Xue L, Xie J, Wu ZB.J Neurosurg. 2026 Jun 26:1-11. doi: 10.3171/2026.1.JNS251768. Online ahead of print.


Repurposing the Antibiotic Tigecycline to Inhibit Tumor Growth and Hormone Secretion in Somatotroph Pituitary Neuroendocrine Tumors.

Yang Z, Liu Y, Wu D, Xu B, Zeng S, Zhang W.Int J Endocrinol. 2026 Jun 24;2026:3784550. doi: 10.1155/ije/3784550. eCollection 2026.


An Explainable Multi-Scale Deep Learning Framework for Multi-Class Brain MRI Classification.

Alshammari HH, Mahmood MA.Diagnostics (Basel). 2026 Jun 10;16(12):1791. doi: 10.3390/diagnostics16121791.

 

Clinical Features and Key Prognostic Indicators of Growth Hormone-Secreting Pituitary Adenomas: A Retrospective Study of 344 Cases.

Zhang Y, Mi Z, Wu H, Ma X, Xi L, Yang Z, Liu P.Curr Oncol. 2026 May 27;33(6):310. doi: 10.3390/curroncol33060310.

 

Pituitary Tumors in Maxillofacial Radiology and Daily Practice: A Scoping Review.

Stucki L, Mauer U, Kildal D, Rózsa NK, Geibel MA.Dent J (Basel). 2026 Jun 15;14(6):368. doi: 10.3390/dj14060368.

 

Radiomics for Preoperative Assessment of Pituitary Adenoma Consistency with T2-Weighted MRI: A Multicenter Study.

Agosti E, Cuocolo R, Mangili M, Rampinelli V, Veiceschi P, Cappelletti M, Panciani PP, Piazza A, Bove I, Solari D, Cavallo LM, Locatelli D, Doglietto F, Fiorindi A, Fontanella MM, Ugga L.J Neurol Surg B Skull Base. 2025 Jun 4;87(3):314-321. doi: 10.1055/a-2607-0735. eCollection 2026 Jun.

 

Acromegaly

Safety and Efficacy of Once-Daily Oral Paltusotine in Acromegaly: ACROBAT Advance Open-Label Extension Up to 4 Years.

Gadelha MR, Gordon MB, Doknic M, Mezősi E, Tóth M, Randeva H, Boguszewski CL, Davidson C, Casagrande A, Jochelson T, Krasner A.J Clin Endocrinol Metab. 2026 Jun 26:dgag254. doi: 10.1210/clinem/dgag254. Online ahead of print.

 

Cushing’s

Twenty years of neurosurgical experience with Cushing’s disease: surgical-strategies, endocrine outcomes and remission predictors in 346 patients.

Honegger J, Grimm F, Gött H, Nasi-Kordhishti I.Eur J Endocrinol. 2026 Jun 26:lvag115. doi: 10.1093/ejendo/lvag115. Online ahead of print.


Catheterization of the petrosal sinus: possible advantage of desmopressin stimulation in Cushing disease.

Garmes HM, Siqueira SC, Daniel KB, Trentin MBF, Fujiwara MT, Schinoll C, Fabbro MD, Rogerio F, Deus-Silva L, Reis F.Arch Endocrinol Metab. 2026 Jun 25;70(4):e260064. doi: 10.20945/2359-4292-2026-0064.

 

Pituitary apoplexy

Activated Macrophages Promote TNF-alpha-Associated Tumor Cell Necroptosis in Pituitary Apoplexy Through the PIEZO1-NFATC2/REL Axis.

Li X, Zhou L, Lei Z, Li S, Wang Q, Zhao H, Xu L, Chen J, Wan X, Huang Y, Lei T.Int J Mol Sci. 2026 Jun 22;27(12):5635. doi: 10.3390/ijms27125635.

 

Pituitary cancer

Beyond the Usual: Breast, Pituitary and Gastric Metastases from Clear Cell Renal Cell Carcinomas-A Case Series with Review of Literature.

Wong YP, Khairuddin NL, Thanabalan J, Tan GC.Diagnostics (Basel). 2026 Jun 9;16(12):1773. doi: 10.3390/diagnostics16121773.

 

Pituitary Metastasis in Lung Cancer Patients: Case Series and Review of the Literature.

Ntouraki S, Roumpou A, Asimakopoulou A, Gkiozos I, Sarropoulou F, Mani M, Marioli A, Bouklas D, Syrigos K, Peppa M.Curr Oncol. 2026 Jun 16;33(6):362. doi: 10.3390/curroncol33060362.

 

Hormonal Health

Salivary Cortisol Response After Ropivacaine-Dexamethasone Administration: A Randomized Clinical Trial.

Stojanović SM, Burić NB, Kostić MS, Burić KN, Stojković BB, Spasić MS, Tijanić M, Trajković M, Jovanović R, Petrović MS.Pharmaceuticals (Basel). 2026 Jun 12;19(6):930. doi: 10.3390/ph19060930.

 

The Global Decline in Sperm Count and Testosterone Levels: Trends, Mechanisms, and Environmental Drivers.

La Vignera S, Condorelli RA.Antioxidants (Basel). 2026 Jun 22;15(6):778. doi: 10.3390/antiox15060778.

 

Microplastics as trojan horses: A new perspective on bisphenol toxicity in male infertility and assisted reproduction.

Marraschi GK, Vitale OG, Kassuya CAL, Jorge BC, Arena AC.Reprod Toxicol. 2026 Jun 25:109298. doi: 10.1016/j.reprotox.2026.109298. Online ahead of print.

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