“He who has health has hope; and he who has hope, has everything.” – Thomas Carlyle
PNA Spotlight: Dr. Juan Fernandez-Miranda
This month the PNA Spotlight focuses on Dr. Juan Carlos Fernandez-Miranda, a Professor of Neurosurgery and the Surgical Director of Brain Tumor, Skull Base and Pituitary Centers at Stanford University. Dr. Fernandez-Miranda did a neurosurgery residency at La Paz University Hospital in Madrid, Spain. He completed a fellowship in microsurgical neuroanatomy at the University of Florida. He did clinical training in cerebrovascular surgery at the University of Virginia, and in endoscopic endonasal and open skull base surgery at University of Pittsburgh Medical Center (UPMC). He joined the faculty at Stanford earlier this year. He was kind enough to answer some questions from the PNA. His answers are below:
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PNA Medical Corner: Cushing Disease and Double Pituitary Adenoma
This month in the PNA Medical Corner we focus on a study coauthored by two members of the PNA: Drs. Adriana Ioachimescu and Nathan Zwagerman. The research is a case study of a woman with two pituitary tumors.
Consecutive resections of double pituitary adenoma for resolution of Cushing disease: illustrative case
Featured News and Updates
The FDA has approved NGENLA (somatrogon-ghla)
The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.
News Articles February 2026
Omics data on pituitary tumors catalogued
A recent study reviewed scientific studies on omics data generated in pituitary tumors. The data has been catalogued to make future research projects easier. Read more: https://www.eurekalert.org/news-releases/1114907
Pituitary cells and intracranial germ cell tumors
A new study looks at role of pituitary cells in the genesis of intracranial germ cell tumors, given that primordial germ cell-like cells reside in the pituitary. The authors call for more study. Read more: https://www.nature.com/articles/s41598-026-38060-2
Benefits of surgery for adrenal Cushing’s
An study in Lancet Diabetes and Endocrinology finds that surgery is more effective at controlling cortisol in patients with adrenal Cushing’s disease compared to a conservative management approach. Read the article in Cushing’s Disease News: https://cushingsdiseasenews.com/news/surgery-offers-best-cortisol-control-adrenal-cushings-syndrome/
Doctors say online influencers spread fear about cortisol
An article in the Associated Press looks at a trend online where influencers focus on the stress hormone cortisol. Some may raise people’s anxiety levels and push them to get unnecessary tests. Read more: https://apnews.com/article/cortisol-supplement-endocrinology-cushing-stress-0f6f6b8df2d11e2560d4e7562f522998
Research Articles
Research Articles February 2026
Pituitary tumors
Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
Chen L, Wang J, Zeng A, Akter F, Wang S, Liu S, Hu W, Yao S, Margetis K, Wang Z, Liu H, Wang X.CNS Neurosci Ther. 2026 Feb;32(2):e70774. doi: 10.1002/cns.70774.
Mauro GP, Rebello LG, Da Róz LM, Gico VC, Weltman E, de Souza EC, Batista RL, da Cunha Neto MBC, Villar RC.Endocrine. 2026 Feb 3;91(1):60. doi: 10.1007/s12020-025-04473-8.
Pediatric craniopharyngioma: when hypoglycemia reveals a brain tumor. Illustrative case.
Hmamouche OM, Hammoud M, Lakhdar F, Benzagmout M, Chakour K, Chaoui El Faiz M.J Neurosurg Case Lessons. 2026 Feb 2;11(5):CASE25727. doi: 10.3171/CASE25727. Print 2026 Feb 2.
Incidental 18F-Flortaucipir Uptake in Pituitary Macroadenoma.
Xiong M, Liu Y, Luo X, Jiang SN.Clin Nucl Med. 2026 Jan 22. doi: 10.1097/RLU.0000000000006313. Online ahead of print.
Yang Z, Maimaiti A, Wu J, Zhou Z, Ding C, Sun H, Li S.J Craniofac Surg. 2026 Feb 2. doi: 10.1097/SCS.0000000000012474. Online ahead of print.
Hariri BA, Faizan M, Balintona R Jr, Elhassan MOE, Salameh S, Mohammad IH, Qasem AM.Case Rep Med. 2026 Jan 30;2026:4124145. doi: 10.1155/carm/4124145. eCollection 2026.
Peng G, Lei X, Leng W, Wu F, Xie L, Long M, Chen L.Front Endocrinol (Lausanne). 2026 Jan 15;16:1698948. doi: 10.3389/fendo.2025.1698948. eCollection 2025.
Optical coherence tomography in preoperative workup and visual outcome of pituitary macroadenomas.
Dal Fabbro M, Moura FC, Atihe C, Sampaio MH, Garmes HM.Surg Neurol Int. 2025 Dec 19;16:533. doi: 10.25259/SNI_908_2025. eCollection 2025.
Dalakas K, Engström BE, Tebani A, Bontell TO, Larsson A, Nord H, Lindskog C, Pontén F, Boldt HB, Ragnarsson O, Casar-Borota O.Acta Neuropathol Commun. 2026 Jan 30. doi: 10.1186/s40478-026-02225-x. Online ahead of print.
Cozma M, Cimpean AM, Parnov M, Corlan AS, Stratulat S, Fala P, Melnic E.Curr Issues Mol Biol. 2025 Dec 25;48(1):27. doi: 10.3390/cimb48010027.
Pediatric and Adult Craniopharyngioma: A 37-Year Experience at a National Referral Center.
Hernández MI, Ibeas C, Fernández JP, Ivanovic-Zuvic D, Gómez M, Gutiérrez D, Valenzuela S, Okuma C.Clin Endocrinol (Oxf). 2026 Jan 30. doi: 10.1111/cen.70103. Online ahead of print.
Oxidative Phosphorylation in Silent Pituitary Adenomas: A Multiomics Perspective.
Chen Y, Zhao Q, Wang X, Wang X, Guo Y.Int J Endocrinol. 2026 Jan 28;2026:8488950. doi: 10.1155/ije/8488950. eCollection 2026.
A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma.
Albasri E, Alghamdi B, Murugan AK, Othman E, Alotaibi S, Dababo MA, Alfares A, Alzahrani AS.Orphanet J Rare Dis. 2026 Jan 29;21(1):32. doi: 10.1186/s13023-025-04161-w.
Pituitary Surgery
Morisako H, Nagahama A, Ikegami M, Sasaki T, Kulkarni AV, Hazunga R, Ichinose T, Teranishi Y, Goto T.Oper Neurosurg. 2026 Feb 3. doi: 10.1227/ons.0000000000001905. Online ahead of print.
Saad DH, Ahmed AMM, ElKholy WM, Bakr MM.BMC Anesthesiol. 2026 Feb 2. doi: 10.1186/s12871-026-03618-0. Online ahead of print.
Cushing’s Disease
New Sparks and Spots: Molecular Imaging with Positron Emission Tomography Will Change Management of Cushing’s Disease.
Reincke M, Apaydin T, Kakashvili M, Albert NL, Thorsteinsdottir J, Schweizer JROL, Theodoropoulou M, Schilbach K, Völter F.Endocrinol Metab (Seoul). 2026 Feb 3. doi: 10.3803/EnM.2025.2728. Online ahead of print.
Recurrent Pituitary Adenoma Causing Cushing’s Disease in a Patient With Lynch Syndrome.
Bares V, Netuka D.Cureus. 2026 Jan 27;18(1):e102414. doi: 10.7759/cureus.102414. eCollection 2026 Jan.
Psychological Recovery after treatment of Cushing syndrome.
Pereira AM, Stenvers DJ.J Clin Endocrinol Metab. 2026 Jan 28:dgag034. doi: 10.1210/clinem/dgag034. Online ahead of print.
Radiation Therapy
Heer A, Schneider M, Boström JP, Pinkawa M, Kovács A, Weller J, Bischoff J, Fries CM, Boström A, Fenske WK.Adv Radiat Oncol. 2025 Oct 31;11(3):101933. doi: 10.1016/j.adro.2025.101933. eCollection 2026 Mar.
Hormonal Health
Neurologic Complications of Endocrine Disorders.
Mustafa R.Continuum (Minneap Minn). 2026 Feb;32(1):105-130. doi: 10.1212/cont.0000000000001658. Epub 2026 Feb 3.
Saul R, David M, Frasch J, Sanchez-Lara PA, Schweiger BM.Case Rep Pediatr. 2026 Jan 28;2026:2247764. doi: 10.1155/crpe/2247764. eCollection 2026.
Menekse B, Ucgul E, Bakir A, Hepsen S, Ozturk Unsal I, Kizilgul M, Araki T, Cakal E.Exp Ther Med. 2026 Jan 16;31(3):71. doi: 10.3892/etm.2026.13066. eCollection 2026 Mar.
Paparella R, Bei A, Bernabei I, Fiorentini C, Iafrate N, Lucibello R, Marchetti L, Pastore F, Maglione V, Niceta M, Fiore M, Caronti B, Vitali M, Pucarelli I, Tarani L.Curr Issues Mol Biol. 2025 Nov 25;47(12):982. doi: 10.3390/cimb47120982.
Isolated Menarche and Empty Sella Turca: A Rare Pediatric Case.
Vieira M, Azevedo IA, Rangel MA, Campos RA, Leite AL.Cureus. 2025 Dec 28;17(12):e100275. doi: 10.7759/cureus.100275. eCollection 2025 Dec.
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