PNA Highlights February 2023 | Pituitary Network Association - International non-profit organization for patients with pituitary tumors and disorders

PNA Spotlight: Tyler J. Kenning

This month the PNA Spotlight focuses on Tyler J. Kenning, MD, FAANS, who serves as director of pituitary and cranial base surgery at Piedmont Brain Tumor Center, part of Piedmont Atlanta Hospital. Dr. Kenning attended medical school at Thomas Jefferson University, graduating in 2005. He did his residency at Albany Medical Center in neurological surgery and completed a fellowship in neurosurgical oncology at Thomas Jefferson University Hospital. Here are Dr. Kenning’s answers to a series of questions posed by the PNA.

News Articles April 2025

Pituitary journey: woman learns to slow down while facing melanoma, pituitary inflammation

Blogger Amanda Goodwin is a hard-charging businesswoman, who was forced to slow down and “embrace the sick” as she battled melanoma in her lungs, liver and brain, and suffered from inflammation of the pituitary. Read more here: https://substack.com/home/post/p-156259244?utm_campaign=post&utm_medium=web

Study: Cushing’s patients develop cataracts at younger ages

An article in Cushing’s Disease News examines a study published in Graefe’s Archive for Clinical and Experimental Ophthalmology, that finds that Cushing’s patients are at higher risk of developing cataracts at a younger age compared to non-Cushing’s patients. They developed them at an average age of 48.1. Patients with Cushing’s Syndrome “being 34% more likely to develop cataracts than the general population. For those with Cushing’s disease, the risk was 39% higher.” Read more: https://cushingsdiseasenews.com/news/cushings-patients-higher-risk-developing-cataracts-younger-age/

Pituitary Journey: British celebrity astrologer recounts battle with pituitary tumor

Russell Grant, a celebrity astrologer in the U.K. who competed on the show “Strictly Come Dancing” recounts his battle with a pituitary tumor, diabetes, and now vision issues. Read more: https://tinyurl.com/44zujvkm

Houston Hospital gets $2 million in donations for pituitary research

Houston Methodist hospital announced it has commitments to receive 2 million dollars to support its Kenneth R. Peak Brain & Pituitary Treatment Center. $1.5 million comes from the Henry J.N. Taub Foundation and is paired with an anonymous $500,000 donation. Read more: https://philanthropynewsdigest.org/news/houston-methodist-receives-1.5-million-for-brain-pituitary-research

Pituitary Surgery

Indocyanine green fluorescence in endoscopic transsphenoidal resection of pituitary neuroendocrine tumors: a systematic review.

Olesrud I, Halvorsen IJ, Storaker MA, Heck A, Dahlberg D, Wiedmann MKH.Acta Neurochir (Wien). 2025 Mar 28;167(1):92. doi: 10.1007/s00701-025-06500-z.

Extended endoscopic endonasal approach for solid or predominantly solid third ventricle craniopharyngiomas complicated with obstructive hydrocephalus: a single-center experience of 27 patients.

Qiao N, Li C, Liu X, Song Y, Liang L, Zou Y, Lu P, Zhang Y, Gui S.Neurosurg Rev. 2025 Mar 26;48(1):325. doi: 10.1007/s10143-025-03486-1.

Transsphenoidal Surgery for Pituitary Neuroendocrine Tumours (PiTNETs) in a Tertiary Hospital: Are There Differences Between Young and Elderly Patients?

Borrego-Soriano I, Parra-Ramírez P, Martín-Rojas-Marcos P, Pérez-López C, García-Feijoo P, Álvarez-Escolá C.Clin Endocrinol (Oxf). 2025 Mar 24. doi: 10.1111/cen.15242. Online ahead of print.PMID: 40129236

Pituitary Tumors

Fungal Sinusitis Spreading to the Sellar Region Mimicking a Pituitary Tumor: Case Report and Literature Review.

Pekic Djurdjevic S, Arsic Arsenijevic V.J Fungi (Basel). 2025 Mar 19;11(3):233. doi: 10.3390/jof11030233.

Functional Transformation of a Corticotroph Pituitary Neuroendocrine Tumor 128 Months Following Primary Excision ? A Case Report.

Goyal-Honavar A, Abraham AP, Asha HS, Chacko G, Chacko AG.Turk Neurosurg. 2025;35(2):355-359. doi: 10.5137/1019-5149.JTN.44912-23.2

Genetic Characterization of Turkish Patients with Pituitary Neuroendocrine Tumors.

Alavanda C, Sonmez O, Geckinli BB, Bayrakli F, Guney AI.Turk Neurosurg. 2025;35(2):319-320. doi: 10.5137/1019-5149.JTN.45761-23.2.

Empty Sella

Relationship Between Radiological Features of Primary Empty or Primary Partial Empty Sella and Pituitary Hormone Levels.

Kałuża B, Furmanek M, Domański J, Żuk-Łapan A, Babula E, Poprawa I, Walecki J, Franek E.Biomedicines. 2025 Mar 15;13(3):722. doi: 10.3390/biomedicines13030722.

Acromegaly

Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly-A Preliminary Study.

Strzelec M, Kubicka E, Kuliczkowska-Płaksej J, Kolačkov K, Janek Ł, Bolanowski M, Jawiarczyk-Przybyłowska A.Biomedicines. 2025 Mar 8;13(3):666. doi: 10.3390/biomedicines13030666.

Hypopituitarism

Identification of POU1F1 Variants in Vietnamese Patients with Combined Pituitary Hormone Deficiency.

Nguyen HT, Nguyen KN, Dien TM, Can TBN, Nguyen TTN, Lien NTK, Tung NV, Xuan NT, Tao NT, Nguyen NL, Tran VK, Mai TTC, Tran VA, Nguyen HH, Vu CD.Int J Mol Sci. 2025 Mar 7;26(6):2406. doi: 10.3390/ijms26062406.

Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis.

Bando H, Urai S, Kanie K, Yamamoto M.Endocr J. 2025 Mar 27. doi: 10.1507/endocrj.EJ25-0035. Online ahead of print.

Hormonal Health

A Novel Missense Variant in LHX4 in Three Children with Multiple Pituitary Hormone Deficiency Belonging to Two Unrelated Families and Contribution of Additional GLI2 and IGFR1 Variant.

Santoro C, Aiello F, Farina A, Miraglia Del Giudice E, Pascarella F, Licenziati MR, Improda N, Piluso G, Torella A, Del Vecchio Blanco F, Cirillo M, Nigro V, Grandone A.Children (Basel). 2025 Mar 14;12(3):364. doi: 10.3390/children12030364.

Hyperprolactinemia is associated with height attainment within or above target height in adult patients with pituitary stalk interruption syndrome.

Wang Y, Mao J, Wang X, Nie M, Zhang J, Zhang W, Liu H, Xu Z, Wu X.Endocr Pract. 2025 Mar 25:S1530-891X(25)00095-3. doi: 10.1016/j.eprac.2025.03.010. Online ahead of print.

Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome Clinical Presentation and the Role of Newer Functional Imaging in the Diagnosis and Management: A Case Report.

Singh R, Goel SA, Singh JS, John DR, Suthar PP.Cureus. 2025 Feb 24;17(2):e79580. doi: 10.7759/cureus.79580. eCollection 2025 Feb.