“The man who earns a million, but destroys his health in the process is not really a success.” – Zig Ziglar

PNA Spotlight: Dr. Kevin Lillehei

Dr. Kevin Lillehei is chair of the Department of Neurosurgery at the University of Colorado School of Medicine in Aurora, Colorado. He started there in 1985 and his primary work is with benign and malignant brain tumors.  He is also codirector of their Pituitary Center of Excellence, and director of the neurosurgery oncology fellowship.  He did his undergraduate work at Cornell University in New York, where he double majored in physics and chemistry.  He then went to medical school at the University of Minnesota and did his residency at the University of Michigan in Ann Arbor, where he really became interested in pituitary tumors. His mentor was Dr. William Chandler, who, at the time, did virtually all of the pituitary tumors at the University of Michigan.  When Dr. Lillihei left Michigan, he spent two years at the University of Colorado’s trauma hospital, which at the time was called Denver General Hospital. After two years there, he transferred over to the University Hospital.  He was kind enough to answer a series of questions from the PNA about his career.

 

What inspired you to choose your career path?

 

At the University of Colorado, they really needed somebody to take over the pituitary tumor surgery part. And I was lucky enough to been at Colorado at the same time as an endocrinologist by the name of Dr. E. Chester Ridgway. And Dr. Ridgway had just come to the University of Colorado from Mass General and the two of us really joined forces and established the pituitary surgery at that time around 1987.  In our pituitary program we do about 140 cases a year, and have a very large network of other interdisciplinary departments that we all work with.

 

What message would you like to convey to your patients?

Read More Here

 

Virtual reality facilitates pituitary tumor resection

Surgery to remove complex pituitary tumors can be challenging, due to the pituitary gland’s location at the base of the skull. To safely reach and remove the tumor, surgeons need deep knowledge of a patient’s skull base anatomy — especially the course of the carotid arteries, which are located on both sides of the pituitary gland and deliver blood to the brain.

“From afar, all pituitary glands might look the same. But surgery is safest when the surgeon understands unique variations in each individual’s anatomy,” says Dr. Bernard R. Bendok, chair of Neurosurgery at Mayo Clinic in Arizona.

Fortunately, neurosurgeons have new imaging tools. Virtual and augmented reality simulations provide 3D visualization of a patient’s skull base and tumor. The visualizations help the treatment team plan the best approach for each individual.

“It’s important for the team to rehearse and have in their minds a 3D picture of the patient’s microanatomy,” Dr. Bendok says. “Mayo Clinic is one of the few centers that has truly integrated virtual and augmented reality into skull base practice.”

During surgery, 3D visualizations can be superimposed onto the patient’s anatomy. “That gives us a kind of ‘X-ray vison’ to see the artery behind the bones and to avoid injury. We can toggle between the imaging and the patient’s anatomy, which is a big benefit,” Dr. Bendok says.

Projecting the visualization onto screens in the operating room allows the entire surgical team to be more informed and engaged in the procedure. “That leads to more safety and accelerates learning curves,” Dr. Bendok says. “Back when I was training, surgeons looked at the surgical field through their own binoculars. Students in the operating room had limited vision of what the surgeons were actually doing. Now, the whole room can follow every nuance throughout the case.”

Virtual and augmented reality simulations also boost patients’ understanding of their tumors. “All our patients get an avatar built with virtual reality. They can put on a headset and walk around their tumor,” Dr. Bendok says. “For most patients, the skull base is a black box. Visualizing it in 3D helps remove the fear of the unknown, and it makes the patient more of a partner in their care.”

“For surgeons, practice makes perfect,” he says. “But conceptualizing the surgery before it happens — visualizing the procedure and understanding how your hands should follow that vision — is at least as important as technique.”

 

Featured News and Updates

News Articles February 2025

Pituitary journey: woman learns to slow down while facing melanoma, pituitary inflammation

Blogger Amanda Goodwin is a hard-charging businesswoman, who was forced to slow down and “embrace the sick” as she battled melanoma in her lungs, liver and brain, and suffered from inflammation of the pituitary. Read more here: https://substack.com/home/post/p-156259244?utm_campaign=post&utm_medium=web

 

Study: Cushing’s patients develop cataracts at younger ages

An article in Cushing’s Disease News examines a study published in Graefe’s Archive for Clinical and Experimental Ophthalmology, that finds that Cushing’s patients are at higher risk of developing cataracts at a younger age compared to non-Cushing’s patients.  They developed them at an average age of 48.1. Patients with Cushing’s Syndrome “being 34% more likely to develop cataracts than the general population. For those with Cushing’s disease, the risk was 39% higher.” Read more: https://cushingsdiseasenews.com/news/cushings-patients-higher-risk-developing-cataracts-younger-age/

 

Pituitary Journey: British celebrity astrologer recounts battle with pituitary tumor

Russell Grant, a celebrity astrologer in the U.K. who competed on the show “Strictly Come Dancing” recounts his battle with a pituitary tumor, diabetes, and now vision issues. Read more: https://tinyurl.com/44zujvkm

Houston Hospital gets $2 million in donations for pituitary research

Houston Methodist hospital announced it has commitments to receive 2 million dollars to support its Kenneth R. Peak Brain & Pituitary Treatment Center. $1.5 million comes from the Henry J.N. Taub Foundation and is paired with an anonymous $500,000 donation. Read more: https://philanthropynewsdigest.org/news/houston-methodist-receives-1.5-million-for-brain-pituitary-research

Research Articles

February 2025 Research Articles

Pituitary Tumors

Etiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents.

Kilci F, Sarikaya E, Murat NÖ, Deniz A.Endocrine. 2025 Feb 2. doi: 10.1007/s12020-025-04176-0. Online ahead of print.

Conservative medical therapy for a macroprolactinoma presenting with obstructive hydrocephalus.

Cuaño PMGM, Isip-Tan IT, Chan KIP.BMJ Case Rep. 2025 Jan 31;18(1):e261540. doi: 10.1136/bcr-2024-261540.

Individual management and prognostic assessment for long-term outcomes using a novel classification system of craniopharyngiomas: a retrospective study of single institution.

Zhang S, Xie B, He Y, Zhang X, Gong G, Li M, Chen Y, Tang G, Zhang C, Qin C, Liu Q.J Cancer Res Clin Oncol. 2025 Jan 31;151(2):57. doi: 10.1007/s00432-025-06104-1.

Mental Health and Pituitary Issues

Psychological burden in patients with sellar masses under conservative and surgical management.

Kalasauskas D, Ernst A, Mireri S, Keric N, Thavarajasingam SG, Omran W, Wüster C, Ringel F, Conrad J.Neurosurg Rev. 2025 Jan 30;48(1):104. doi: 10.1007/s10143-025-03240-7.

Social functioning longitudinal trajectory and its predictors in young and middle-aged postoperative pituitary tumor patients: A growth mixture model.

Zhou Y, Qian M, Wang S, Zhou X, Zhou M, Gu Z, Sun M, Yang T.Eur J Oncol Nurs. 2025 Jan 28;74:102815. doi: 10.1016/j.ejon.2025.102815. Online ahead of print.

Pituitary Surgery


Giant and irregular pituitary neuroendocrine tumors surgery: comparison of simultaneous combined endoscopic endonasal and transcranial and purely endoscopic endonasal surgery at a single center.

Fu J, Luo W, Zhang C, Wang Z, Fan W, Lin Y, Kang D, Song J, Jiang C, Yan X.Chin Neurosurg J. 2025 Feb 3;11(1):3. doi: 10.1186/s41016-025-00389-4.PMID: 39894800

Modified graded skull base reconstruction for intraoperative CSF leak repair in endoscopic endonasal surgeries: a single-surgeon experience in initial years of practice and nuances in the early learning curve.

Khaleghi M, Shahid AH, Suggala S, Dyess G, Hummel UN, Chason DN, Butler D, Thakur JD.Neurosurg Focus. 2025 Feb 1;58(2):E6. doi: 10.3171/2024.11.FOCUS24733.

Does the crafted abdominal fat grafting technique completely eliminate risk of postoperative CSF leak in endonasal pituitary surgery? Technical note and preliminary clinical outcome.

Lasica N, Lesha E, Beckfort NS, Arnautovic KI.Neurosurg Focus. 2025 Feb 1;58(2):E3. doi: 10.3171/2024.11.FOCUS24665.

Multicenter study on 2-year outcomes of dual application of hydroxyapatite cranioplasty and a nasoseptal flap following endoscopic endonasal surgery for tuberculum sellae meningiomas or craniopharyngiomas.

Kong DS, Kim YH, Hong SD, Ryu G, Kim JH, Hong CK, Kim YH.Neurosurg Focus. 2025 Feb 1;58(2):E2. doi: 10.3171/2024.11.FOCUS24624.


Risk Factors for Development of Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone Secretion after Transsphenoidal Resection of Pituitary Adenoma.

Petito G, Hu A, Zhang G, Min S, Tripathi SH, Kumar A, Shukla G, Shah S, Phillips KM, Jana S, Forbes JA, Zuccarello M, Andaluz NO, Sedaghat AR.J Neurol Surg B Skull Base. 2024 Feb 2;86(1):39-45. doi: 10.1055/a-2235-7419. eCollection 2025 Feb.PMID: 39881750

Cushing’s

Performance of Vasopressin Stimulated Bilateral Inferior Petrosal Sinus Sampling in Corticotropin Dependent Cushing’s Syndrome with Negative or Equivocal 3 Tesla Contrast Enhanced Magnetic Resonance Imaging of Pituitary.

Shivnani P, Kasliwal R, Goyal G, Sharma J, Balani U, Gupta P, Sharma BS, Yadav D, Mishra V, Sharma SK.Indian J Endocrinol Metab. 2024 Nov-Dec;28(6):589-595. doi: 10.4103/ijem.ijem_60_24. Epub 2024 Dec 30.

Hormonal health

The hypothalamus and pituitary gland regulate reproduction and are involved in the development of polycystic ovary syndrome.

Long BY, Liao X, Liang X.Neuroendocrinology. 2025 Jan 31:1-26. doi: 10.1159/000543877. Online ahead of print.

Cabergoline-induced NDFIP1 upregulation in pituitary neuroendocrine tumor cells activates mTOR signaling and contributes to cabergoline resistance.

Gu W, Zhang W, Wu Z, Cai Y.J Neurooncol. 2025 Feb 1. doi: 10.1007/s11060-025-04949-7. Online ahead of print.

Count on your Xeris CareConnection™ Team for unparalleled Cushing’s Support

Cushing’s can be challenging, but there is support so patients can feel like themselves again. The main goal of treating Cushing’s is to get cortisol levels back to normal. This Pituitary Awareness Month, Xeris Pharmaceuticals® is highlighting the importance of one-on-one support for patients living with Cushing’s Syndrome and support for HCPs treating Cushing’s Syndrome.

Sign up to get dedicated support:

Patients: Sign up for support | Recorlev® (levoketoconazole)

HCP’s: Connect with Xeris support | RECORLEV® (levoketoconazole)

Have more questions? Call for more support at 1-844-444-RCLV (7258)

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