“Your body hears everything your mind says.” – Naomi Judd

PNA Spotlight: Dr. Bernard R. Bendok

This month the PNA Spotlight focuses on Bernard R. Bendok, M.D., the William J. and Charles H. Mayo Professor and Chair of Neurological Surgery at Mayo Clinic in Arizona. He was kind enough to answer a few questions from the PNA. Here are his answers, lightly edited for clarity.

Please tell us about your early life, and why you chose pituitary medicine.

I was born in Detroit, and at age five, we moved to Harper Woods, so I spent my childhood living along Lake St. Clair. From age nine to fifteen I lived in Lebanon because my parents moved us there for family and work reasons. In ninth grade during the biology lecture on pituitary disease, in that moment, I decided to be a doctor. My passion for pituitary disease really stems back to this day. I remember distinctly: I was so amazed that this little gland could be a symphony conductor of the body. I didn’t know anything about being a doctor. We have no physicians in the family. Nobody had talked to me about being a doctor. But I knew, at that moment, that I was going to be a doctor. I didn’t know I was going to be a neurosurgeon, but I knew I was going to be a doctor.

Please tell us about your medical training and your mentors.

I went to medical school and did my residency training at Northwestern. I did my fellowship at SUNY Buffalo. While in medical school I learned from a pioneer in pituitary diseases named Dr. Ivan Ciric. He was a towering figure, an amazing surgeon, and an incredible human being. I had the privilege of writing the review of his autobiography, called “Listen to the patient.”  It’s a phenomenal book about health care and the passion and joy of being a doctor, and so I was inspired by him.

Read More Here

 

PNA Medical Corner: Endoscopic Endonasal Transsphenoidal Surgery

This month the PNA Medical Corner showcases a study co-authored by several PNA-affiliated specialists: Drs. Joao Paulo Almeida, Juan Carlos Fernandez Miranda, and Daniel Prevedello. The study proposes an intraoperative framework to confirm safe phase progression in endonasal transsphenoidal surgery.

Pituitary  2026 Jan 28;29(1):35.

doi: 10.1007/s11102-026-01636-2.

Critical views for safe surgical phase progression in endoscopic endonasal transsphenoidal pituitary adenoma resection: modified Delphi consensus

Tjasa Zaletel # 1 2Danyal Z Khan # 3 4Anjana Wijekoon 5 6Zhehua Mao 5 6Joao Paulo Almeida 7Anouk Borg 2Jonathan Chainey 8Michael D Cusimano 9Daniel A Donoho 10 11Neil Dorward 2Juan Carlos Fernandez-Miranda 12Giorgio Fiore 13Theofanis Giannis 2Alfonso Lagares Gomez-Abascal 14 15 16Lauren Harris 2Abhiney Jain 2 5Ruth Lau 17Sacit B Omay 18Igor Paredes 14 15 16Daniel Prevedello 19Gabriel Zada 20

Danail Stoyanov 5 6Sophia Bano 5 6Hani J Marcus 2 5

Affiliations Expand

Abstract

Purpose: Endonasal transsphenoidal surgery is the gold-standard for pituitary adenoma resection, yet no intraoperative framework exists to confirm safe phase progression. Inspired by the Critical View of Safety in laparoscopic cholecystectomy and engineering “phase-gate” process, we propose the Critical Views for Phase Progression (CVPPs) – a set of visual cues confirming phase objectives and safe phase progression. Designed to be clinically relevant and machine-readable, CVPPs aim to support training and future AI-driven guidance systems.

Methods: A three-round modifi

ed Delphi process was conducted involving 15 pituitary surgery experts from 13 centres across Europe and North America. CVPPs for the naso-sphenoid, sellar, and closure phases were classified as “Essential”, “Desirable” or “Not Necessary”. Consensus required ≥ 70% agreement. A local validation study was subsequently performed involving six experts who reviewed 15 intraoperative video clips and rated their confidence to proceed, which was compared against the predefined reference derived from the finalised CVPPs.

Results: Consensus identified essential and desirable CVPPs across all three phases for both micro- and macroadenoma variants, reflecting differences in exposure goals and surgical risk. Validation demonstrated high concordance between participant ratings and predefined references. Discrepancies arose only in a minority of intentionally incomplete (“unsafe”) views and were attributable to contextual misinterpretation of short video segments, rather than disagreement with the CVPP framework.

Conclusion: This international, multicentre consensus is the first to define CVPPs. By standardising intraoperative visual benchmarks, CVPPs can enhance training, mitigate risks, and provide a foundation for future AI-driven guidance systems capable of real-time anatomical annotation and decision support.

Keywords: CVPP; Consensus; Delphi; Endoscopic endonasal; Endoscopic transsphenoidal surgery; Pituitary adenoma.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethical approval: Ethical approval and informed consent were unnecessary due to the nature of the study (consensus process amongst health care professionals). Participation in this study was voluntary. Competing interests: HJM is an employee of and has shares in Panda Surgical. DS is an employee of Digital Surgery, Medtronic and has shares in Panda Surgical, Odin Vision, EnAcuity and Helico Medical. JPA is a consultant for Stryker. MDC serves on the Pfizer Medical Advisory Board.

Featured News and Updates

News Articles February 2026

Omics data on pituitary tumors catalogued

A recent study reviewed scientific studies on omics data generated in pituitary tumors.  The data has been catalogued to make future research projects easier. Read more: https://www.eurekalert.org/news-releases/1114907

 

Pituitary cells and intracranial germ cell tumors

A new study looks at role of pituitary cells in the genesis of intracranial germ cell tumors, given that primordial germ cell-like cells reside in the pituitary. The authors call for more study. Read more: https://www.nature.com/articles/s41598-026-38060-2

 

Benefits of surgery for adrenal Cushing’s

An study in Lancet Diabetes and Endocrinology finds that surgery is more effective at controlling cortisol in patients with adrenal Cushing’s disease compared to a conservative management approach. Read the article in Cushing’s Disease News: https://cushingsdiseasenews.com/news/surgery-offers-best-cortisol-control-adrenal-cushings-syndrome/

 

Doctors say online influencers spread fear about cortisol

An article in the Associated Press looks at a trend online where influencers focus on the stress hormone cortisol. Some may raise people’s anxiety levels and push them to get unnecessary tests. Read more: https://apnews.com/article/cortisol-supplement-endocrinology-cushing-stress-0f6f6b8df2d11e2560d4e7562f522998

Research Articles

Research Articles February 2026

Pituitary tumors
Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.

Chen L, Wang J, Zeng A, Akter F, Wang S, Liu S, Hu W, Yao S, Margetis K, Wang Z, Liu H, Wang X.CNS Neurosci Ther. 2026 Feb;32(2):e70774. doi: 10.1002/cns.70774.

 

Radiotherapy regimens and concurrent Cabergoline use for non-functioning pituitary neuroendocrine tumors: a large, single-center cohort.

Mauro GP, Rebello LG, Da Róz LM, Gico VC, Weltman E, de Souza EC, Batista RL, da Cunha Neto MBC, Villar RC.Endocrine. 2026 Feb 3;91(1):60. doi: 10.1007/s12020-025-04473-8.

 

Pediatric craniopharyngioma: when hypoglycemia reveals a brain tumor. Illustrative case.

Hmamouche OM, Hammoud M, Lakhdar F, Benzagmout M, Chakour K, Chaoui El Faiz M.J Neurosurg Case Lessons. 2026 Feb 2;11(5):CASE25727. doi: 10.3171/CASE25727. Print 2026 Feb 2.

 

Incidental 18F-Flortaucipir Uptake in Pituitary Macroadenoma.

Xiong M, Liu Y, Luo X, Jiang SN.Clin Nucl Med. 2026 Jan 22. doi: 10.1097/RLU.0000000000006313. Online ahead of print.

 

Exploring the Genetic Correlation Between Pituitary Adenomas and Psychiatric Disorders: Insights From Genome-Wide Association Studies.

Yang Z, Maimaiti A, Wu J, Zhou Z, Ding C, Sun H, Li S.J Craniofac Surg. 2026 Feb 2. doi: 10.1097/SCS.0000000000012474. Online ahead of print.

 

A Case Report of Growth Hormone-Secreting Pituitary Adenoma Complicated by Apoplexy With Atypical Clinical Presentation.

Hariri BA, Faizan M, Balintona R Jr, Elhassan MOE, Salameh S, Mohammad IH, Qasem AM.Case Rep Med. 2026 Jan 30;2026:4124145. doi: 10.1155/carm/4124145. eCollection 2026.

 

Lugol’s solution for preoperative management of a TSH/GH-secreting pituitary adenoma with suboptimal response to octreotide: a case report.

Peng G, Lei X, Leng W, Wu F, Xie L, Long M, Chen L.Front Endocrinol (Lausanne). 2026 Jan 15;16:1698948. doi: 10.3389/fendo.2025.1698948. eCollection 2025.

 

Optical coherence tomography in preoperative workup and visual outcome of pituitary macroadenomas.

Dal Fabbro M, Moura FC, Atihe C, Sampaio MH, Garmes HM.Surg Neurol Int. 2025 Dec 19;16:533. doi: 10.25259/SNI_908_2025. eCollection 2025.

 

Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.

Dalakas K, Engström BE, Tebani A, Bontell TO, Larsson A, Nord H, Lindskog C, Pontén F, Boldt HB, Ragnarsson O, Casar-Borota O.Acta Neuropathol Commun. 2026 Jan 30. doi: 10.1186/s40478-026-02225-x. Online ahead of print.


Exploring the Dynamic Interaction Between Pituitary Neuroendocrine Tumors (Pit-NETs) Cells and Their Angiogenic Microenvironment by Using the MIB1 Labeling Index, VEGF Expression and Digital Image Analysis.

Cozma M, Cimpean AM, Parnov M, Corlan AS, Stratulat S, Fala P, Melnic E.Curr Issues Mol Biol. 2025 Dec 25;48(1):27. doi: 10.3390/cimb48010027.

 

Pediatric and Adult Craniopharyngioma: A 37-Year Experience at a National Referral Center.

Hernández MI, Ibeas C, Fernández JP, Ivanovic-Zuvic D, Gómez M, Gutiérrez D, Valenzuela S, Okuma C.Clin Endocrinol (Oxf). 2026 Jan 30. doi: 10.1111/cen.70103. Online ahead of print.

 

Oxidative Phosphorylation in Silent Pituitary Adenomas: A Multiomics Perspective.

Chen Y, Zhao Q, Wang X, Wang X, Guo Y.Int J Endocrinol. 2026 Jan 28;2026:8488950. doi: 10.1155/ije/8488950. eCollection 2026.


A novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma.

Albasri E, Alghamdi B, Murugan AK, Othman E, Alotaibi S, Dababo MA, Alfares A, Alzahrani AS.Orphanet J Rare Dis. 2026 Jan 29;21(1):32. doi: 10.1186/s13023-025-04161-w.

 

Pituitary Surgery

Endoscopic Endonasal Approach With Extradural Posterior Clinoidectomy and Upper Clivectomy for Retrochiasmatic Craniopharyngiomas.

Morisako H, Nagahama A, Ikegami M, Sasaki T, Kulkarni AV, Hazunga R, Ichinose T, Teranishi Y, Goto T.Oper Neurosurg. 2026 Feb 3. doi: 10.1227/ons.0000000000001905. Online ahead of print.

 

Ultrasound-guided percutaneous versus trans-nasal pterygopalatine fossa block in endoscopic trans-sphenoidal pituitary gland surgery: a randomized controlled trial.

Saad DH, Ahmed AMM, ElKholy WM, Bakr MM.BMC Anesthesiol. 2026 Feb 2. doi: 10.1186/s12871-026-03618-0. Online ahead of print.

 

Cushing’s Disease
New Sparks and Spots: Molecular Imaging with Positron Emission Tomography Will Change Management of Cushing’s Disease.

Reincke M, Apaydin T, Kakashvili M, Albert NL, Thorsteinsdottir J, Schweizer JROL, Theodoropoulou M, Schilbach K, Völter F.Endocrinol Metab (Seoul). 2026 Feb 3. doi: 10.3803/EnM.2025.2728. Online ahead of print.

 

Recurrent Pituitary Adenoma Causing Cushing’s Disease in a Patient With Lynch Syndrome.

Bares V, Netuka D.Cureus. 2026 Jan 27;18(1):e102414. doi: 10.7759/cureus.102414. eCollection 2026 Jan.


Psychological Recovery after treatment of Cushing syndrome.

Pereira AM, Stenvers DJ.J Clin Endocrinol Metab. 2026 Jan 28:dgag034. doi: 10.1210/clinem/dgag034. Online ahead of print.

 

Radiation Therapy

Low Incidence of New-Onset Hypopituitarism After High-Precision Stereotactic Radiation Therapy of Sellar and Perisellar Lesions.

Heer A, Schneider M, Boström JP, Pinkawa M, Kovács A, Weller J, Bischoff J, Fries CM, Boström A, Fenske WK.Adv Radiat Oncol. 2025 Oct 31;11(3):101933. doi: 10.1016/j.adro.2025.101933. eCollection 2026 Mar.

 

Hormonal Health
Neurologic Complications of Endocrine Disorders.

Mustafa R.Continuum (Minneap Minn). 2026 Feb;32(1):105-130. doi: 10.1212/cont.0000000000001658. Epub 2026 Feb 3.


PPP1R12A Mutation Presenting With Congenital Jejunal Atresia and Short Stature: A Pediatric Endocrinology Case Report.

Saul R, David M, Frasch J, Sanchez-Lara PA, Schweiger BM.Case Rep Pediatr. 2026 Jan 28;2026:2247764. doi: 10.1155/crpe/2247764. eCollection 2026.


Identification of a novel KISS1R (GPR54) gene variant (c.505+2T>G) in a patient with congenital hypogonadotropic hypogonadism: A case report and literature review.

Menekse B, Ucgul E, Bakir A, Hepsen S, Ozturk Unsal I, Kizilgul M, Araki T, Cakal E.Exp Ther Med. 2026 Jan 16;31(3):71. doi: 10.3892/etm.2026.13066. eCollection 2026 Mar.


Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives.

Paparella R, Bei A, Bernabei I, Fiorentini C, Iafrate N, Lucibello R, Marchetti L, Pastore F, Maglione V, Niceta M, Fiore M, Caronti B, Vitali M, Pucarelli I, Tarani L.Curr Issues Mol Biol. 2025 Nov 25;47(12):982. doi: 10.3390/cimb47120982.

 

Isolated Menarche and Empty Sella Turca: A Rare Pediatric Case.

Vieira M, Azevedo IA, Rangel MA, Campos RA, Leite AL.Cureus. 2025 Dec 28;17(12):e100275. doi: 10.7759/cureus.100275. eCollection 2025 Dec.

 

 

Count on your Xeris CareConnection™ Team for unparalleled Cushing’s Support

Cushing’s can be challenging, but there is support so patients can feel like themselves again. The main goal of treating Cushing’s is to get cortisol levels back to normal. This Pituitary Awareness Month, Xeris Pharmaceuticals® is highlighting the importance of one-on-one support for patients living with Cushing’s Syndrome and support for HCPs treating Cushing’s Syndrome.

Sign up to get dedicated support:

Patients: Sign up for support | Recorlev® (levoketoconazole)

HCP’s: Connect with Xeris support | RECORLEV® (levoketoconazole)

Have more questions? Call for more support at 1-844-444-RCLV (7258)

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