Cheerfulness is the best promoter of health and is as friendly to the mind as to the body

-Joseph Addison

PNA Spotlight: Dr. Brian Williams

This month the PNA Spotlight focuses on Dr. Brian Williams, an Assistant Professor in the Department of Neurosurgery at the University of Louisville, where he leads the Division of Neurosurgical Oncology, Skull Base Surgery and Pituitary Surgery.  Dr. Williams earned his medical degree from the Baylor College of Medicine in Houston, Texas. He did a residency in neurological surgery at the University of Virginia in Charlottesville, followed by a fellowship in Neurosurgical Oncology at MD Anderson Hospital in Houston.  He also pursued specialty training in cerebrovascular and skull base surgery at the Auckland City Hospital in New Zealand.  He was kind enough to answer some questions from the PNA. His answers are below

Dr. Brian Williams

PNA Medical Corner: Otolaryngology Pioneers of Transsphenoidal Surgery

This month the PNA Medical Corner focuses on an article co-authored by Dr. Edward Laws, a longtime member of the PNA. The research looks at the considerable impact two early otolaryngologists, Markus Hajek and Oskar Hirsch, had in developing endonasal transsphenoidal pituitary surgery. 

Dr. Edward Laws

Featured News and Updates

News Articles February 2023

Bones of 18th Century Acromegalic Taken Off Museum Display

Photo courtesy of the Queen Mary University of London.

The bones of an 18th century acromegalic Irish man named Charles Byrne were on display as a medical curiosity for 140 years before being taken off display, in accordance with his last wishes. Byrne was almost 8 feet tall when he died in 1783 and had requested a burial at sea, however a friend sold his body to a surgeon named John Hunter. It eventually ended up on display at the Hunterian Museum, which is affiliated with the Royal College of Surgeons of England. Read more:



Transsphenoidal Pituitary Neurosurgery: A Moment by Moment Account

Dr. Mazda Turel, a neurosurgeon in Mumbai, India, tells the story of a transsphenoidal surgery he performed. He explains each step in a drama with perilous twists and turns. Read more:

Cushing’s Case Report: Severe Infection and Electrolyte Imbalance

An article in Cushing’s Disease News looks at the case of an 82-year-old woman who presented with a severe muscle infection and an imbalance of electrolytes. She was diagnosed with Cushing’s but passed away from infectious complications from a surgery before she could be treated for Cushing’s. Read more:

11-year-old Patient Battles Tumor Pressing on Pituitary

An article in Spring tells the story of an 11-year-old girl who is battling optic nerve hypoplasia – and has a schwannoma pressing on her pituitary. Read more:



Research Articles

February 2023 Research Articles

Pituitary Tumors

MRI-based brain tumor detection using convolutional deep learning methods and chosen machine learning techniques.

Cathepsin D Inhibits Angiogenesis in Pituitary Neuroendocrine Tumors.

Pituitary adenoma “pneumo-apoplexy”.

Improved Detection of Cavernous Sinus Invasion of Pituitary Macroadenomas with Ultra-High-Field 7 T MRI.

Risk Factor and Replacement Therapy Analysis of Pre- and Postoperative Endocrine Deficiencies for Craniopharyngioma.

The Morphology of the Pituitary Gland: A Meta-Analysis with Implications for Diagnostic Imaging.

Pituitary Surgery

Preoperative frailty status measured by Clinical Risk Analysis Index and adverse events after endoscopic endonasal transsphenoidal resection of pituitary adenoma: results of a single center prospective case series.

Closure strategy for endoscopic pituitary surgery: Experience from 3015 patients.

Pre-Surgery Patient Health Contributes to Aggravated Sino-Nasal Outcome and Quality of Life after Pituitary Adenomectomy.

Clinical Applicability of the Sellar Barrier Concept in Patients with Pituitary Apoplexy: Is It Possible?

Pituitary Cancer

Case Report: Pituitary metastasis as a presenting manifestation of silent gastric cardia adenocarcinoma.

COVID and the Pituitary

The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome.


Advances in Molecular Pathophysiology and Targeted Therapy for Cushing’s Disease.


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