PNA Highlights June 2022

The awareness that health is dependent upon habits that we control makes us the first generation in history that to a large extent determines its own destiny.

Jimmy Carter

PNA Spotlight: Dr. Adam Mamelak

This month the PNA Spotlight focuses on Dr. Adam Mamelak, a neurosurgeon and co-director of the Pituitary Center at Cedars Sinai Medical Center in Los Angeles. Dr. Mamelak earned his B.A. in Physics at Tuft University and earned his MD from Harvard Medical School. He did a surgical internship and then a residency at the University of California at San Francisco Medical Center. He did a fellowship at the Epilepsy Research Laboratory at UCSF, and another postdoctoral fellowship in neuroscience at the California Institute of Technology & Huntington Medical Research Institutes in Pasadena, California. Dr. Mamelak was kind enough to answer a series of questions from the PNA. His answers follow.

What inspired you to choose your career path?

PNA Medical Corner: Incipient Gigantism

This month the PNA Medical Corner highlights an article co-authored by Dr. Albert Beckers, a longtime member of the PNA. The study looks at the case of a 7-year-old boy with a pituitary tumor due to a gene mutation. They conclude that not all tumors of this type respond to pasireotide.
AACE Clin Case Rep
. 2021 Dec 16;8(3):119-123.
doi: 10.1016/j.aace.2021.12.003. eCollection May-Jun 2022.

Complicated Clinical Course in Incipient Gigantism Due to Treatment-resistant Aryl Hydrocarbon Receptor-Interacting Protein-mutated Pediatric Somatotropinoma

• PMID: 35602875 PMCID: PMC9123570 DOI: 10.1016/j.aace.2021.12.003

Abstract
Background: Our objective was to describe the clinical course and treatment challenges in a very young patient with a pituitary adenoma due to a novel aryl hydrocarbon receptor-interacting protein (AIP) gene mutation, highlighting the limitations of somatostatin receptor immunohistochemistry to predict clinical responses to somatostatin analogs in acromegaly.