The winners in life treat their body as if it were a magnificent spacecraft that gives them the finest transportation and endurance for their lives.

-Denis Waitley

 

PNA Spotlight: Dr. William Couldwell

This month the PNA Spotlight focuses on William Couldwell, MD, PhD, who serves as Professor and Chair of the Department of Neurosurgery at the University of Utah. He is also a member of the PNA’s Scientific Advisory Panel. He studied at the University of British Columbia in Vancouver and at Dalhousie University in Halifax, Nova Scotia, majoring in physical chemistry and biology. Dr. Couldwell attended medical school at McGill University in Montreal. He did internship in surgery at the University of Southern California and completed a neurosurgical residency there in 1989. He served as a research fellow in neuroimmunology at the Montreal Neurological Institute and Hospital and research fellow in the neurosurgical service in Lausanne, Switzerland. He returned to U-S-C as an assistant professor of neurological surgery in 1991, where he stayed for four years. Later he became professor and chairman of the Department of Neurological Surgery at New York Medical College, as well as program director of neurosurgical residency in 1997. In 2001 he became professor and chairman of the Department of Neurosurgery at the University of Utah. Dr. Couldwell was kind enough to answer some questions from the PNA. His answers follow.

PNA Medical Corner: Fascia Lata in Reconstructive Neurosurgery

This month the PNA Medical Corner showcases an article co-authored by a member of the PNA, Dr. Varun Kshettry of the Cleveland Clinic. The study concludes that the use of fascia lata in challenging cases of skull base reconstruction is highly effective with few side effects for cases of craniopharyngioma, meningioma and more.

https://pubmed.ncbi.nlm.nih.gov/37081750/

Abstract

Background: Multiple methods exist for skull base reconstruction of defects created by expanded endonasal approaches. While the nasoseptal flap (NSF) has been well established as the workhorse of mucosal reconstruction in complex skull base defects in multi-layered closures, a variety of options exist for the inner layer of multilayer reconstruction, including fascia lata (FL).

Objective: To present our experience and outcomes in utilizing FL in multiple ways to reconstruct a wide variety of complex skull base defects

Featured News and Updates

News Articles June 2026

Woman diagnosed with both Cushing’s Disease and Syndrome

An study in Cureus details the rare case of a Moroccan woman diagnosed with both Cushing’s Disease and Cushing’s Syndrome.  She had been self-medicating with dexamethasone. Read more: https://www.cureus.com/articles/494214-is-it-possible-to-have-coexisting-exogenous-and-endogenous-cushings-syndrome#!/

Real Housewife, former beauty queen tells her pituitary story

Kelsey Swanson, a cast member of Real Housewives of Rhode Island and a former Miss Rhode Island discusses her battle with a pituitary tumor in an article in Yahoo.com. Read more: https://www.yahoo.com/entertainment/tv/articles/breaking-down-rhori-kelsey-swanson-150326808.html

Study links radiotherapy to increased mortality in pituitary patients

An article in Medscape looks at a study on radiotherapy in patients with pituitary tumors and found increased mortality rates. Read more: https://www.medscape.com/viewarticle/increased-mortality-after-radiotherapy-pituitary-adenoma-2026a1000gmy

Pituitary mass mistaken for migraine in expectant mother

An article in the Times of India explains the case of a pregnant woman with debilitating headaches and vision loss. Doctors initially thought she had migraines, when it turned out to be a suprasellar mass. Read more: https://timesofindia.indiatimes.com/health/severe-headache-during-pregnancy-turned-out-to-be-a-1-in-9-million-pituitary-disorder-after-symptoms-were-mistaken-for-migraine/articleshow/131293833.cms

 

 

Research Articles

Research Articles June 2026

Pituitary Tumors


Pituitary adenomas associated with hydrocephalus: clinical characteristics, risk stratification, and clinical management.

Zhou W, Yu M, Cheng S, Zhu H, Cao L, Li Z, Liu C, Bai J, Zhao P, Zhang Y, Gui S, Li C.J Neurooncol. 2026 May 29;178(1):31. doi: 10.1007/s11060-026-05653-w.

Organoids as next-generation models for investigating intracranial tumours.

Roy S, Zahin F, Nkrumah-Boateng PA, Chaudhry S, Nassor M, Kwarteng MFA, Owusu-Boampong AB, Wireko AA.Mol Brain. 2026 May 30. doi: 10.1186/s13041-026-01317-y. Online ahead of print.PMID: 42218467 Review.

Enhancing brain tumor classification with a simplified CNN through hyperparameter optimization.

Remzan N, Tahiry K, Farchi A, Arbi A.Biomed Phys Eng Express. 2026 May 29. doi: 10.1088/2057-1976/ae74d5. Online ahead of print.PMID: 42214387

LAT1-mediated amino acid metabolism reprogramming: a novel metabolic vulnerability in recurrent pituitary neuroendocrine tumors.

Pei ZJ, Li GW, Yu JH, Yang HR, Fang Y, Zhou LX.Endocr Connect. 2026 May 29:EC-25-0860. doi: 10.1530/EC-25-0860. Online ahead of print.


Osteometabolic complications in patients with secreting pituitary adenomas: Is there an impact of gender?

di Filippo L, Acanfora M, Bolamperti S, Terenzi U, Bonomo M, Giustina A.Pituitary. 2026 May 29;29(3):96. doi: 10.1007/s11102-026-01667-9.


The hook effect in macroprolactinomas: tumor size thresholds, prolactin patterns, and clinical consequences – a systematic review.

Yadav P, Hamrahian AH, Salvatori R.Pituitary. 2026 May 29;29(3):98. doi: 10.1007/s11102-026-01705-6.

 

Pituitary Surgery


Systematic anatomical validation of the endoscopic mononostril transethmoid-paraseptal approach to the central skull base.

Eördögh M, Weidemeier M, Baksa G, Patonay L, Simmen D, Schroeder HWS, El Refaee E, Hosemann W, Reisch R, Briner HR.Brain Spine. 2026 May 15;6:106092. doi: 10.1016/j.bas.2026.106092. eCollection 2026.

 

Pituitary apoplexy

Management-specific outcome evaluation of pituitary apoplexy; conservative and surgical approach.

Guijt MC, Verstegen MJT, Zamanipoor Najafabadi AH, Bakker LEH, Notting IC, Pelsma ICM, van Furth WR, Biermasz NR, Claessen KMJA.Pituitary. 2026 May 29;29(3):97. doi: 10.1007/s11102-026-01695-5.

 

Acromegaly

Speckle-tracking echocardiography reveals the synergistic impact of GH/IGF-1 excess and metabolic dysregulation on cardiac dysfunction in acromegaly.

Chen M, Zhang P, He W, Jin J, Huang R, Liao Z, Xiao H, Yao F, Li Y, Li H.Pituitary. 2026 May 29;29(3):95. doi: 10.1007/s11102-026-01684-8.

 

Cushing’s disease

Real-Time PCR-Based Intraoperative Molecular Boundary Diagnosis of Corticotroph Pituitary Neuroendocrine Tumors.

Sato Y, Takeuchi K, Ohka F, Nagata Y, Maeda S, Matsuyama T, Hirose T, Deguchi S, Okumura E, Iwami K, Saito R.J Neurosci Methods. 2026 May 28:110814. doi: 10.1016/j.jneumeth.2026.110814. Online ahead of print.PMID: 42214473

 

Hyperprolactinemia


Transient Hyperprolactinemia Associated With Semaglutide in a Patient With Hashimoto’s Thyroiditis.

Guimarães GNF.Case Rep Med. 2026 May 27;2026:3016596. doi: 10.1155/carm/3016596. eCollection 2026.

 

Hormonal Health

Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants.

Joseph J, Søndergaard E, Knorr S, Knudsen JH, Rittig S, Christensen JH.Clin Genet. 2026 May 29. doi: 10.1111/cge.70183. Online ahead of print.

 

 

Copyright © 2024 Pituitary Network Association All rights reserved.

Disclaimer: PNA does not engage in the practice of medicine. It is not a medical authority, nor does it claim to have medical expertise. In all cases, PNA recommends that you consult your own physician regarding any course of treatment or medication.

Our mailing address is:
Pituitary Network Association
P.O. Box 1958
Thousand Oaks, CA 91358
(805) 499-9973 Phone - (805) 480-0633 Fax
Email [email protected]

You are receiving this Newsletter because you have shown interest in receiving information about our activities.

If you do not want to receive any more emails from PNA, Unsubscribe.