The winners in life treat their body as if it were a magnificent spacecraft that gives them the finest transportation and endurance for their lives.

-Denis Waitley

 

PNA Spotlight: Dr. William Couldwell

This month the PNA Spotlight focuses on William Couldwell, MD, PhD, who serves as Professor and Chair of the Department of Neurosurgery at the University of Utah. He is also a member of the PNA’s Scientific Advisory Panel. He studied at the University of British Columbia in Vancouver and at Dalhousie University in Halifax, Nova Scotia, majoring in physical chemistry and biology. Dr. Couldwell attended medical school at McGill University in Montreal. He did internship in surgery at the University of Southern California and completed a neurosurgical residency there in 1989. He served as a research fellow in neuroimmunology at the Montreal Neurological Institute and Hospital and research fellow in the neurosurgical service in Lausanne, Switzerland. He returned to U-S-C as an assistant professor of neurological surgery in 1991, where he stayed for four years. Later he became professor and chairman of the Department of Neurological Surgery at New York Medical College, as well as program director of neurosurgical residency in 1997. In 2001 he became professor and chairman of the Department of Neurosurgery at the University of Utah. Dr. Couldwell was kind enough to answer some questions from the PNA. His answers follow.

PNA Medical Corner: Fascia Lata in Reconstructive Neurosurgery

This month the PNA Medical Corner showcases an article co-authored by a member of the PNA, Dr. Varun Kshettry of the Cleveland Clinic. The study concludes that the use of fascia lata in challenging cases of skull base reconstruction is highly effective with few side effects for cases of craniopharyngioma, meningioma and more.

https://pubmed.ncbi.nlm.nih.gov/37081750/

Abstract

Background: Multiple methods exist for skull base reconstruction of defects created by expanded endonasal approaches. While the nasoseptal flap (NSF) has been well established as the workhorse of mucosal reconstruction in complex skull base defects in multi-layered closures, a variety of options exist for the inner layer of multilayer reconstruction, including fascia lata (FL).

Objective: To present our experience and outcomes in utilizing FL in multiple ways to reconstruct a wide variety of complex skull base defects

Featured News and Updates

News Articles November 2025

News Articles November 2025

Case report: from pituitary tumor to metastatic cancer

An article on Cureus.com looks at the case of a 35-year-old man with a lactrotroph pituitary adenoma that progressed to a metastatic pituitary carcinoma. In this rare case, the cancer is “resistant to surgery, radiation, and medical treatments.“  Read more: https://www.cureus.com/articles/348490-transformation-of-lactotroph-pituitary-adenoma-to-metastatic-pituitary-carcinoma-a-case-report#!/

Patient story: Musician Lou Gramm on his battle with a pituitary tumor

An article on blabbermouth.net features the pituitary story of musician Lou Gramm of the group “Foreigner”, who had surgery for a craniopharyngioma in 1997 after suffering headaches and memory loss.  Read more: https://blabbermouth.net/news/lou-gramm-says-he-couldnt-remember-the-words-to-foreigners-classic-songs-shortly-after-his-brain-surgery

Researchers use artificial intelligence to screen for childhood hormone deficiency

An article in EMJ Reviews looks at a study on whether artificial intelligence can predict growth hormone deficiency in children of short stature. The machine learning model examines MRI scans of the pituitary and has shown good results. In the future, this could lead doctors to order fewer invasive growth hormone stimulation tests for children. Read more: https://www.emjreviews.com/en-us/amj/radiology/news/mri-radiomics-model-predicts-childhood-hormone-deficiency/

Patient on off-label cabergoline develops impulse control disorder as tumor grows

An study in Cureus.com examines the case of a 19-year-old man with a prolactinoma who was given off-label cabergoline at three times the normal dose for ten years. He developed an impulse control disorder and a spending and gambling problem, and was lost to follow-up. Radiosurgery was rejected, as the patient was deemed unable to comply with the necessary follow-up regime. It was later discovered that his tumor was resistant to cabergoline and had grown and extended into the cavernous sinus, making it inoperable. Read more: https://www.cureus.com/articles/416467-giant-prolactinoma-resistant-to-high-dose-cabergoline-in-a-young-male-lost-to-follow-up#!/

 

Research Articles

November 2025 Research Articles

 Pituitary tumors


Interrogation of the cellular hierarchies reveals neoplastic evolution and therapeutic vulnerability in craniopharyngioma.

Zhang B, Zhang J, Li Z, Sheng H, Li H, Lu Y, Liu X, Xu Z, Huang Y, Zhu C, Wen Y, He X, Zhang L.Neuro Oncol. 2025 Oct 24:noaf249. doi: 10.1093/neuonc/noaf249. Online ahead of print.

 

Unusual Dual Brain Tumor Morphologies in an MEN1 Patient: A Case Report of Diagnostic Challenges and Methylation Insights.

Patel V, Aboud O, Barakat A.Int J Mol Sci. 2025 Oct 16;26(20):10065. doi: 10.3390/ijms262010065.

 

Pituitary surgery
Global Growth and Distribution of CyberKnife Stereotactic Radiosurgery: A Bibliometric Analysis.

Annagiri S, Hori YS, Persad ARL, Ustrzynski L, Emrich SC, Tayag A, Park DJ, Adler JR, Chang SD.Neurosurg Pract. 2025 Jul 10;6(3):e000150. doi: 10.1227/neuprac.0000000000000150. eCollection 2025 Sep.

 

Imaging

Combined Use of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in the Differential Diagnosis of Sellar Tumors: A Single-Centre Experience.

Korbecki A, Łukasiewicz M, Kacała A, Sobański M, Zdanowicz-Ratajczyk A, Szałata K, Dorochowicz M, Korbecka J, Trybek G, Zimny A, Bladowska J.J Clin Med. 2025 Oct 11;14(20):7168. doi: 10.3390/jcm14207168.


A swarm intelligence-driven hybrid framework for brain tumor classification with enhanced deep features.

Yonar A.Sci Rep. 2025 Oct 28;15(1):37543. doi: 10.1038/s41598-025-23820-3.

 

Acromegaly

Paltusotine: The first selective nonpeptide agonist of somatostatin receptor 2 (SSTR2) for the treatment of acromegaly.

Sun Y, Lu D, Gao J.Drug Discov Ther. 2025 Oct 29. doi: 10.5582/ddt.2025.01109. Online ahead of print.

 

Hematological Malignancy in a Hypophysectomised Acromegalic Patient Under 4-Year Therapy with Somatostatin Analogues: From a Rib Lump Underlying Bone Plasmatocytoma Features to Multiple Myeloma.

Stanciu M, Cătană A, Ristea RP, Tanasescu D, Carsote M, Popa FL, Lebădă IC.Diagnostics (Basel). 2025 Oct 17;15(20):2623. doi: 10.3390/diagnostics15202623.

 

Cushing’s

Three Cases of Ectopic, Cyclic Cushing Syndrome: A New Square Wave Variant.

Martinez-Gil M, Tshimbombu TN, Li Yi Ang Y, Rodriguez MC, Yuen KCJ.JCEM Case Rep. 2025 Oct 28;3(12):luaf176. doi: 10.1210/jcemcr/luaf176. eCollection 2025 Dec.

 

Selective Hippocampal Subfield Atrophy Mediates Cognitive Decline in Cushing’s Disease.

Feng Z, Zhou T, Yan X, He K, Liu H, Yu X, Lu R, Ma Z, Yu X, Zhang Y.Brain Behav. 2025 Nov;15(11):e71030. doi: 10.1002/brb3.71030.

 

Hormonal health

 

Awareness of post-transplant endocrine disorders among kidney transplant clinicians: results of an Italian survey.

Pellegrini B, Cantaluppi V, Aimaretti G, Ferraresso M, Romagnoli J, Silvestre C, Comai G, Maggiore U, Leone F, Greco R, Maggiolini M, Provenzano M, Zaza G; Joint Committee of the Italian Society of Organ Transplantation and the Italian Society of Nephrology.J Endocrinol Invest. 2025 Oct 29. doi: 10.1007/s40618-025-02741-y. Online ahead of print.

 

 

 

 

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