The winners in life treat their body as if it were a magnificent spacecraft that gives them the finest transportation and endurance for their lives.
-Denis Waitley
PNA Spotlight: Dr. William Couldwell
This month the PNA Spotlight focuses on William Couldwell, MD, PhD, who serves as Professor and Chair of the Department of Neurosurgery at the University of Utah. He is also a member of the PNA’s Scientific Advisory Panel. He studied at the University of British Columbia in Vancouver and at Dalhousie University in Halifax, Nova Scotia, majoring in physical chemistry and biology. Dr. Couldwell attended medical school at McGill University in Montreal. He did internship in surgery at the University of Southern California and completed a neurosurgical residency there in 1989. He served as a research fellow in neuroimmunology at the Montreal Neurological Institute and Hospital and research fellow in the neurosurgical service in Lausanne, Switzerland. He returned to U-S-C as an assistant professor of neurological surgery in 1991, where he stayed for four years. Later he became professor and chairman of the Department of Neurological Surgery at New York Medical College, as well as program director of neurosurgical residency in 1997. In 2001 he became professor and chairman of the Department of Neurosurgery at the University of Utah. Dr. Couldwell was kind enough to answer some questions from the PNA. His answers follow.
PNA Medical Corner: Fascia Lata in Reconstructive Neurosurgery
This month the PNA Medical Corner showcases an article co-authored by a member of the PNA, Dr. Varun Kshettry of the Cleveland Clinic. The study concludes that the use of fascia lata in challenging cases of skull base reconstruction is highly effective with few side effects for cases of craniopharyngioma, meningioma and more.
https://pubmed.ncbi.nlm.nih.gov/37081750/
Abstract
Background: Multiple methods exist for skull base reconstruction of defects created by expanded endonasal approaches. While the nasoseptal flap (NSF) has been well established as the workhorse of mucosal reconstruction in complex skull base defects in multi-layered closures, a variety of options exist for the inner layer of multilayer reconstruction, including fascia lata (FL).
Objective: To present our experience and outcomes in utilizing FL in multiple ways to reconstruct a wide variety of complex skull base defects
Featured News and Updates
News Articles July 2024
Hormonal Disruptions and Pituitary Tumors
An endocrinologist in India discusses the hormonal disruption experienced by pituitary patients. Read more: https://www.hindustantimes.com/lifestyle/health/hormonal-disruptions-caused-by-pituitary-tumours-endocrinologist-shares-insights-101718974544057.html
Novel Cushing’s Treatment in Phase 2 Trials
The pharmaceutical company Lundbeck is now in Phase 2 clinical trials to assess a “potential first-in-class” treatment for Cushing’s disease called LuAG13909. Read more:
Pain in Men vs Women: The Role of Hormones
An article in Very Well Health looks at a study on how pain is produced and felt in women versus men. The researchers found that the hormone prolactin lowered the threshold to activate specialized sensory cells called nociceptors in female cells but did not in male cells. However the neuropeptide orexin B had the opposite effect. This could have implications for pain management, as women make up a large percentage of patients seeking treatment for pain. Read more:
https://www.verywellhealth.com/women-and-men-have-differences-in-pain-production-8665947
Hormonal Disruptions and Pituitary Tumors
An endocrinologist in India discusses the hormonal disruption experienced by pituitary patients. Read more: https://www.hindustantimes.com/lifestyle/health/hormonal-disruptions-caused-by-pituitary-tumours-endocrinologist-shares-insights-101718974544057.html
Research Articles
July 2024 Research Articles
Pituitary Tumors
Genome-Wide DNA Methylation Profiling as a Prognostic Marker in Pituitary Adenomas-A Pilot Study.
Møller MW, Andersen MS, Halle B, Pedersen CB, Boldt HB, Tan Q, Jurmeister PS, Herrgott GA, Castro AV, Petersen JK, Poulsen FR.Cancers (Basel). 2024 Jun 13;16(12):2210. doi: 10.3390/cancers16122210.
Zhu Z, Hu B, Zhu D, Li X, Chen D, Wu N, Rao Q, Zhang Z, Wang H, Zhu Y.J Endocrinol Invest. 2024 Jun 26. doi: 10.1007/s40618-024-02408-0. Online ahead of print.
Chiari I Malformation With Concomitant Nonfunctioning Pituitary and Adrenal Tumors.
Zielinski R, Khan A, Mirza FS.JCEM Case Rep. 2024 Jun 25;2(6):luae113. doi: 10.1210/jcemcr/luae113. eCollection 2024 Jun.
Pituitary Surgery
Adams OE, Olson SB, Lam H, Judge C, McClelland C, Lee MS, Venteicher AS.Neuroophthalmology. 2024 Jan 26;48(4):272-278. doi: 10.1080/01658107.2023.2299763. eCollection 2024.
Kemchoknatee P, Singhakul C, Arjkongharn N, Vongsa N, Tangon D, Srisombut T.Clin Ophthalmol. 2024 Jun 21;18:1779-1788. doi: 10.2147/OPTH.S463303. eCollection 2024.
Acromegaly
Personalized medicine in acromegaly: The ACROFAST study.
Marques-Pamies M, Gil J, Sampedro-Nuñez M, Valassi E, Biagetti B, Giménez-Palop O, Hernández M, Martínez S, Carrato C, Villar-Taibo R, Araujo-Castro M, Blanco C, Simón-Muela I, Simó-Servat A, Xifra G, Vázquez F, Pavón I, Rosado JA, García-Centeno R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez-Escola C, Picó A, Salinas I, Fajardo-Montañana C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M, Puig-Domingo M.J Clin Endocrinol Metab. 2024 Jun 29:dgae444. doi: 10.1210/clinem/dgae444. Online ahead of print.
Glucose metabolism outcomes after pituitary surgery in patients with acromegaly.
Pascual-Corrales E, Biagetti B, Marazuela M, Asensio-Wandosel D, Rodríguez Berrocal V, Irigaray Echarri A, Novo-Rodríguez C, Calatayud M, Bernabéu I, Alvarez-Escola C, Tenorio-Jiménez C, González Molero I, Iglesias P, Blanco C, de Miguel P, López Mezquita E, Lamas C, Aulinas A, Gracia P, Recio-Córdova JM, Sampedro-Nuñez M, Paja M, Moure Rodríguez MD, Fajardo-Montañana C, Cordido F, Menéndez Torre E, Percovich JC, García-Centeno R, Cámara R, Hanzu FA, Vicente Delgado A, González Fernández L, Guerrero-Pérez F, Ollero García-Agulló MD, Novoa-Testa I, Villar-Taibo R, Benítez Valderrama P, Abellán Galiana P, Venegas Moreno E, Vidal-Ostos De Lara F, Enseñat J, Aznar S, Asla Q, Aviles-Pérez MD, Puig-Domingo M, Araujo-Castro M. Pituitary. 2024 Jun 28. doi: 10.1007/s11102-024-01415-x. Online ahead of print.
Cardiac MRI in acromegaly: looking for a big heart.
Schweizer JROL, Nachtigall LB.Pituitary. 2024 Jun 28. doi: 10.1007/s11102-024-01417-9. Online ahead of print.
Risk of intracranial meningioma in patients with acromegaly: a systematic review.
Guo AX, Job A, Pacione D, Agrawal N.Front Endocrinol (Lausanne). 2024 Jun 11;15:1407615. doi: 10.3389/fendo.2024.1407615. eCollection 2024.
Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.
Cho J, Kim JH, Kim YH, Lee J.Endocrinol Metab (Seoul). 2024 Jun 26. doi: 10.3803/EnM.2024.1933. Online ahead of print.
Pituitary tumor centers of excellence (PTCOE): the next border of acromegaly treatment.
Grottoli S, Ghigo E.Pituitary. 2024 Jun 25. doi: 10.1007/s11102-024-01416-w. Online ahead of print.
Pituitary Apoplexy
Pituitary apoplexy: a systematic review of non-gestational risk factors.
Kajal S, Ahmad YES, Halawi A, Gol MAK, Ashley W.Pituitary. 2024 Jun 27. doi: 10.1007/s11102-024-01412-0. Online ahead of print.
Mullins J, Bryniarski M.Cureus. 2024 May 28;16(5):e61259. doi: 10.7759/cureus.61259. eCollection 2024 May.
Hormonal Health
Evaluation and Surgical Management of Multiple Endocrine Neoplasias.
Frye CC, Brown TC, Olson JA Jr.Surg Clin North Am. 2024 Aug;104(4):909-928. doi: 10.1016/j.suc.2024.02.016. Epub 2024 Apr 4.
Identification of the FSH-RH as the other gonadotropin-releasing hormone.
Uehara SK, Nishiike Y, Maeda K, Karigo T, Kuraku S, Okubo K, Kanda S.Nat Commun. 2024 Jun 27;15(1):5342. doi: 10.1038/s41467-024-49564-8.
Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants.
Martin LJ, Touaibia M.Nutrients. 2024 Jun 9;16(12):1815. doi: 10.3390/nu16121815.
Roux A, Rosso D, Cuboni D, Maccario M, Grottoli S, Arvat E, Gasco V.Biomedicines. 2024 Jun 19;12(6):1368. doi: 10.3390/biomedicines12061368.
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