“Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship.” – Buddha

 

PNA Spotlight: Dr. Aaron Cohen-Gadol

This month the PNA Spotlight focuses on Dr. Aaron Cohen-Gadol, a professor at Indiana University Department of Neurosurgery. He is the director of neurosurgical oncology and its fellowship, and co-director of the Signature Center for Brain and Neurological Tumors. Dr. Cohen-Gadol earned his undergraduate degree from the University
of California at San Diego and attended medical school at the University of Southern California. He then completed his residency training at Mayo Clinic in Rochester, Minnesota. He also completed fellowship training in two subspecialties: epilepsy surgery (Yale University) and skull base/cerebrovascular surgery (University of Arkansas.) In addition, Dr. Cohen holds a Master’s Degree in Clinical Research from Mayo Graduate School and an MBA from Kelley School of Business. His areas of interest include surgical treatment of complex intracranial tumors and vascular lesions.

He is the founder and president of The Neurosurgical Atlas (https://www.neurosurgicalatlas.com), a multimedia resource for neurosurgical techniques. Dr. Cohen-Gadol was kind enough to answer some questions posed by the PNA. His answers follow.

Count on your Xeris CareConnection™ Team for unparalleled Cushing’s Support

Cushing’s can be challenging, but there is support so patients can feel like themselves again. The main goal of treating Cushing’s is to get cortisol levels back to normal. This Pituitary Awareness Month, Xeris Pharmaceuticals® is highlighting the importance of one-on-one support for patients living with Cushing’s Syndrome and support for HCPs treating Cushing’s Syndrome.

Sign up to get dedicated support:

Patients: Sign up for support | Recorlev® (levoketoconazole)

HCP’s: Connect with Xeris support | RECORLEV® (levoketoconazole)

Have more questions? Call for more support at 1-844-444-RCLV (7258)

PNA Medical Corner: Somatotroph Adenoma in a Young Adult

This month the PNA Medical Corner spotlights an article co-authored by a member of the PNA, Dr. Ursula Kaiser, Chief of the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. The case report looks at early onset excess of growth hormone in the context of a somatotroph adenoma in a young adult.

Link: https://doi.org/10.1210/jcemcr/luad030

Early Onset GH Excess: Somatotroph Adenoma in a Young Adult

Featured News and Updates

The FDA has approved NGENLA (somatrogon-ghla)

The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.

See the Press Release here>

News Articles October 2025

News Articles October 2025

When Cushing’s becomes cancer: metastasis or induced by radiation?

An article in Cushing’s Disease News looks at a study that examines the case of two women whose benign tumors associated with Cushing’s disease turned malignant.  The question is whether they metastasized or if radiation could have induced the transformation.  More info: https://cushingsdiseasenews.com/news/cushings-pituitary-tumors-rarely-aggressive-cancers/

Pituitary apoplexy: symptomatic vs asymptomatic

A study in the Journal of Clinical Neuroscience looks at the clinical profile of patients with and without symptoms of pituitary apoplexy.  Symptoms include “headache, vomiting and cranial nerve palsies.”  People without symptoms who suffered pituitary apoplexy had lower white blood cell counts and lower blood sodium levels. Read more: https://www.sciencedirect.com/science/article/abs/pii/S0967586825005983

When a pituitary macroadenoma causes sepsis-like symptoms

A study on Cureus.com presents a case report where a woman was initially treated for sepsis but turned out to have a pituitary macroadenoma.  Read more: https://assets.cureus.com/uploads/case_report/pdf/413034/20250912-112610-bm0ldk.pdf

 Acute Sheehan’s Syndrome after post-partum pituitary hemorrhage

A case study presented on Cureus.com looks at the patient who gave birth, suffered a pituitary hemorrhage, and developed acute Sheehan’s Syndome and then pituitary atrophy eight months postpartum. Read more: https://assets.cureus.com/uploads/case_report/pdf/411201/20250914-401650-bm0ldk.pdf

 

Research Articles

October 2025 Research Articles

Pituitary tumors


A new and useful tool for differentiating prolactinomas from non-functioning pituitary adenomas: a pilot study of the cabergoline disconnection test.

Galliano SA, Stumpf MAM, Queiroz NL, Ferreira EHR, Craveiro FL, Gruetzmacher C, Silva GOD, Cescato VAS, Vellutini EAS, Cunha-Neto MBC, Batista RL, Glezer A.Einstein (Sao Paulo). 2025 Sep 15;23:eAO1694. doi: 10.31744/einstein_journal/2025AO1694. eCollection 2025.

 

The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors.

Pugazenthi S, Pari SS, Zhang Z, Silverstein J, Kim AH, Patel B.Front Med (Lausanne). 2025 Sep 1;12:1629621. doi: 10.3389/fmed.2025.1629621. eCollection 2025.

 

Limitations of MRI in differentiating solid and cystic components of craniopharyngiomas.

Karaalioğlu B, Öksüz NÇ, İpek V, Çakır A, Kahraman O, Özbek MA.Childs Nerv Syst. 2025 Sep 16;41(1):281. doi: 10.1007/s00381-025-06941-y.


Idiopathic Arginine Vasopressin Deficiency With an Incidental Non-functional Pituitary Microadenoma in an Elderly Diabetic Woman.

Krishna MSV, Babu DVSP, Singh M, Madhavan S.Cureus. 2025 Aug 13;17(8):e89995. doi: 10.7759/cureus.89995. eCollection 2025 Aug.

 

Cushing’s Disease


Changing face of Cushing’s disease over three decades in pituitary center.

Muradov I, Sahin S, Uysal S, Sulu C, Gunebakan P, Tunc A, Kocaman BB, Soltanova L, Gazioglu N, Tanriover N, Kadioglu P.J Endocrinol Invest. 2025 Sep 16. doi: 10.1007/s40618-025-02702-5. Online ahead of print.

Editor’s note:  Dr. Gazioglu is a member of the PNA.


Update on Medical Treatment of Cushing’s Syndrome.

Dillon BR, Agrawal N, Schwarz Y, Dancel-Manning K, Tabarin A, Lacroix A, Hofland LJ, Feelders RA.Drugs. 2025 Sep 15. doi: 10.1007/s40265-025-02223-8. Online ahead of print.

 

Acromegaly

Metabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross-Sectional Study in China.

Tagilapalli SK, Wang Z, Lu YL, Zhang G, Su W, Wu Z, Wang J, Rao Q, Wang H, He D, Mou Y, Yao S, Tie Y, Chen W.CNS Neurosci Ther. 2025 Sep;31(9):e70607. doi: 10.1111/cns.70607.

 

Imaging

Trade-Off Analysis of Classical Machine Learning and Deep Learning Models for Robust Brain Tumor Detection: Benchmark Study.

Tian Y.JMIR AI. 2025 Sep 15;4:e76344. doi: 10.2196/76344.

 

Hormonal health


Idiopathic hyperprolactinemia-associated hypogonadism in men presenting with normal testosterone levels.

Cheng X, Xiao Y, Deng Y, Chen Q, Wen X, Zhou E, Zhou H.PLoS One. 2025 Sep 18;20(9):e0332871. doi: 10.1371/journal.pone.0332871. eCollection 2025.

 

Evaluation of thyrotrophic and lactotrophic reserves in patients with pituitary dwarfism with and without empty sella turcica.

Geremia C, Geremia F.J Pediatr Endocrinol Metab. 2025 Jul 21;38(9):904-914. doi: 10.1515/jpem-2025-0082. Print 2025 Sep 25.

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