“Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship.” – Buddha

 

PNA Spotlight: Dr. Aaron Cohen-Gadol

This month the PNA Spotlight focuses on Dr. Aaron Cohen-Gadol, a professor at Indiana University Department of Neurosurgery. He is the director of neurosurgical oncology and its fellowship, and co-director of the Signature Center for Brain and Neurological Tumors. Dr. Cohen-Gadol earned his undergraduate degree from the University
of California at San Diego and attended medical school at the University of Southern California. He then completed his residency training at Mayo Clinic in Rochester, Minnesota. He also completed fellowship training in two subspecialties: epilepsy surgery (Yale University) and skull base/cerebrovascular surgery (University of Arkansas.) In addition, Dr. Cohen holds a Master’s Degree in Clinical Research from Mayo Graduate School and an MBA from Kelley School of Business. His areas of interest include surgical treatment of complex intracranial tumors and vascular lesions.

He is the founder and president of The Neurosurgical Atlas (http://www.neurosurgicalatlas.com), a multimedia resource for neurosurgical techniques. Dr. Cohen-Gadol was kind enough to answer some questions posed by the PNA. His answers follow.

Count on your Xeris CareConnection™ Team for unparalleled Cushing’s Support

Cushing’s can be challenging, but there is support so patients can feel like themselves again. The main goal of treating Cushing’s is to get cortisol levels back to normal. This Pituitary Awareness Month, Xeris Pharmaceuticals® is highlighting the importance of one-on-one support for patients living with Cushing’s Syndrome and support for HCPs treating Cushing’s Syndrome.

Sign up to get dedicated support:

Patients: Sign up for support | Recorlev® (levoketoconazole)

HCP’s: Connect with Xeris support | RECORLEV® (levoketoconazole)

Have more questions? Call for more support at 1-844-444-RCLV (7258)

PNA Medical Corner: Somatotroph Adenoma in a Young Adult

This month the PNA Medical Corner spotlights an article co-authored by a member of the PNA, Dr. Ursula Kaiser, Chief of the Division of Endocrinology, Diabetes and Hypertension at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. The case report looks at early onset excess of growth hormone in the context of a somatotroph adenoma in a young adult.

Link: https://doi.org/10.1210/jcemcr/luad030

Early Onset GH Excess: Somatotroph Adenoma in a Young Adult

Featured News and Updates

The FDA has approved NGENLA (somatrogon-ghla)

The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.

See the Press Release here>

News Articles June 2024

Can machine learning improve diagnosis of hormone imbalance?

A study in the journal Academic Radiology looks at the use of machine learning to analyze pituitary MRI images (radiomics) and clinical data – and finds it is helpful in the diagnostic process to differentiate between growth hormone deficiency and idiopathic short stature.  Read more: https://www.academicradiology.org/article/S1076-6332(24)00293-9/abstract

Personality changes after pituitary surgery

An article in Medical News Today looks at the personality changes patients can experience after undergoing pituitary surgery. They include mood shifts, depression, anxiety, irritability, aggression, confusion and apathy. Read more:

https://www.medicalnewstoday.com/articles/personality-changes-after-pituitary-surgery#personality-changes

Study: 80% remission rate after 2nd Cushing’s surgery

An article in Cushing’s Disease News looks at a study from the journal Pituitary that found that 80% of patients who had a second surgery for Cushing’s Disease achieved remission. Read more: https://cushingsdiseasenews.com/news/remission-most-cushings-patients-after-2nd-pituitary-surgery/

North Carolina Congressman battles pituitary tumor

Congressman Greg Murphy from North Carolina will be undergoing surgery to remove a pituitary macroadenoma. Dr. Murphy is also a urologist. Read more: https://www.13newsnow.com/article/news/local/north-carolina/outer-banks/congressman-greg-murphy-surgery-brain-tumor-nc-obx/291-2dc18304-d151-426e-b792-6ef74b18708c

Ohio stuntman fights acromegaly, jumps cars

An Ohio news station featured the story of Raymond Kohn, who jumps the General Lee car over big ramps at stunt shows as part of the Northeast Ohio Dukes. But there’s a twist – Kohn is also battling acromegaly and had transsphenoidal surgery to remove the tumor. Watch the story: https://www.wfmj.com/clip/15470193/warren-stunt-driver-overcomes-brain-tumor

 

Research Articles

June 2024 Research Articles

Pituitary Tumors

High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma.

Giant Clinically Non-Functioning Pituitary Adenoma Presenting as New Onset Generalized Tonic-Clonic Seizures: A Case Report.

Polyuria, Sinopulmonary Symptoms, and Pituitary Mass.


Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas.

 

Pituitary  Surgery

Endoscopic endonasal transsphenoidal approach improves endocrine function and surgical outcome in primary craniopharyngioma resection: a systematic review and meta-analysis.


Endoscopic Endonasal Internal Carotid Artery Transposition Technique in Tumor With Parasellar Extension: A Single-Center Experience.

 

Pituitary Imaging
Comparative analysis of intraoperative and imaging features of invasive growth in pituitary adenomas

Magnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma.

Role of artificial intelligence in brain tumour imaging.

 

Acromegaly
Exploring potential influencing factors of inadherence to specialist aftercare and long-term medication in patients with acromegaly.

 

Cushing’s

ACTH-dependent Cushing Syndrome with No Peripheral Response But a Marked Petrosal Sinus ACTH Response to Desmopressin.

Cushing Syndrome Due to a Corticotropin-Releasing Hormone- and Adrenocorticotropic Hormone-Secreting Silent Pheochromocytoma.

Treatment modalities and outcomes in pediatric Cushing’s disease – report of three cases and literature review.

Pituitary Apoplexy

Comparing neuroendocrine recovery between surgical and conservative management in pituitary apoplexy patients: a propensity score-matched analysis.

 

Hypopituitarism

Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management.
Progress, challenges and perspectives in the management of hypopituitarism.

Hormonal health

Anterior pituitary gland volume mediates associations between pubertal hormones and changes in transdiagnostic symptoms in youth.

 

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