The way you think, the way you behave, the way you eat, can influence your life by 30 to 50 years.
-Deepak Chopra
PNA Spotlight: Dr. Manish Aghi
This month the PNA Spotlight focuses on Dr. Manish K. Aghi.Dr. Manish Aghi is a neurosurgeon specializing in brain tumors at UCSF Medical Center. He cares for adult patients with a wide range of conditions, including astrocytomas and anaplastic astrocytomas, oligodendrogliomas, glioblastomas, meningiomas and pituitary adenomas. As principal investigator at the UCSF Brain Tumor Research Center, his interests include glioblastoma angiogenesis, mechanisms of glioblastoma resistance to anti-angiogenic therapy and experimental glioblastoma therapies such as cancer-killing viruses.
Professor Aghi earned his medical degree and a doctoral degree in neurosciences from Harvard Medical School. He completed a residency in neurosurgery at Massachusetts General Hospital. He is a member of the Society for Neuro-Oncology, American Association of Neurological Surgeons, Congress of Neurological Surgeons and Pituitary Network Association. Among his honors are the Preuss and Mahaley awards from the American Association of Neurological Surgeons, and the Ronald L. Bittner Award, Synthes Skull Base Award and Integra Foundation Award from the Congress of Neurological Surgeons.
His answers follow.
PNA Medical Corner: Pituitary Centers of Excellence
This month the PNA Medical Corner focuses on an article co-authored by several members and colleagues of the PNA: Drs. Chanson, Kaiser, Laws, van der Lely, and Melmed. It addresses a topic that PNA has sought to promote for decades: the designation of Pituitary Centers of Excellence, where patients can get highly specialized care
Link: https://pubmed.ncbi.nlm.nih.gov/37640885/
Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers
Featured News and Updates
The FDA has approved NGENLA (somatrogon-ghla)
The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.
News Articles July 2024
Hormonal Disruptions and Pituitary Tumors
An endocrinologist in India discusses the hormonal disruption experienced by pituitary patients. Read more: https://www.hindustantimes.com/lifestyle/health/hormonal-disruptions-caused-by-pituitary-tumours-endocrinologist-shares-insights-101718974544057.html
Novel Cushing’s Treatment in Phase 2 Trials
The pharmaceutical company Lundbeck is now in Phase 2 clinical trials to assess a “potential first-in-class” treatment for Cushing’s disease called LuAG13909. Read more:
Pain in Men vs Women: The Role of Hormones
An article in Very Well Health looks at a study on how pain is produced and felt in women versus men. The researchers found that the hormone prolactin lowered the threshold to activate specialized sensory cells called nociceptors in female cells but did not in male cells. However the neuropeptide orexin B had the opposite effect. This could have implications for pain management, as women make up a large percentage of patients seeking treatment for pain. Read more:
https://www.verywellhealth.com/women-and-men-have-differences-in-pain-production-8665947
Hormonal Disruptions and Pituitary Tumors
An endocrinologist in India discusses the hormonal disruption experienced by pituitary patients. Read more: https://www.hindustantimes.com/lifestyle/health/hormonal-disruptions-caused-by-pituitary-tumours-endocrinologist-shares-insights-101718974544057.html
Research Articles
July 2024 Research Articles
Pituitary Tumors
Genome-Wide DNA Methylation Profiling as a Prognostic Marker in Pituitary Adenomas-A Pilot Study.
Møller MW, Andersen MS, Halle B, Pedersen CB, Boldt HB, Tan Q, Jurmeister PS, Herrgott GA, Castro AV, Petersen JK, Poulsen FR.Cancers (Basel). 2024 Jun 13;16(12):2210. doi: 10.3390/cancers16122210.
Zhu Z, Hu B, Zhu D, Li X, Chen D, Wu N, Rao Q, Zhang Z, Wang H, Zhu Y.J Endocrinol Invest. 2024 Jun 26. doi: 10.1007/s40618-024-02408-0. Online ahead of print.
Chiari I Malformation With Concomitant Nonfunctioning Pituitary and Adrenal Tumors.
Zielinski R, Khan A, Mirza FS.JCEM Case Rep. 2024 Jun 25;2(6):luae113. doi: 10.1210/jcemcr/luae113. eCollection 2024 Jun.
Pituitary Surgery
Adams OE, Olson SB, Lam H, Judge C, McClelland C, Lee MS, Venteicher AS.Neuroophthalmology. 2024 Jan 26;48(4):272-278. doi: 10.1080/01658107.2023.2299763. eCollection 2024.
Kemchoknatee P, Singhakul C, Arjkongharn N, Vongsa N, Tangon D, Srisombut T.Clin Ophthalmol. 2024 Jun 21;18:1779-1788. doi: 10.2147/OPTH.S463303. eCollection 2024.
Acromegaly
Personalized medicine in acromegaly: The ACROFAST study.
Marques-Pamies M, Gil J, Sampedro-Nuñez M, Valassi E, Biagetti B, Giménez-Palop O, Hernández M, Martínez S, Carrato C, Villar-Taibo R, Araujo-Castro M, Blanco C, Simón-Muela I, Simó-Servat A, Xifra G, Vázquez F, Pavón I, Rosado JA, García-Centeno R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez-Escola C, Picó A, Salinas I, Fajardo-Montañana C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M, Puig-Domingo M.J Clin Endocrinol Metab. 2024 Jun 29:dgae444. doi: 10.1210/clinem/dgae444. Online ahead of print.
Glucose metabolism outcomes after pituitary surgery in patients with acromegaly.
Pascual-Corrales E, Biagetti B, Marazuela M, Asensio-Wandosel D, Rodríguez Berrocal V, Irigaray Echarri A, Novo-Rodríguez C, Calatayud M, Bernabéu I, Alvarez-Escola C, Tenorio-Jiménez C, González Molero I, Iglesias P, Blanco C, de Miguel P, López Mezquita E, Lamas C, Aulinas A, Gracia P, Recio-Córdova JM, Sampedro-Nuñez M, Paja M, Moure Rodríguez MD, Fajardo-Montañana C, Cordido F, Menéndez Torre E, Percovich JC, García-Centeno R, Cámara R, Hanzu FA, Vicente Delgado A, González Fernández L, Guerrero-Pérez F, Ollero García-Agulló MD, Novoa-Testa I, Villar-Taibo R, Benítez Valderrama P, Abellán Galiana P, Venegas Moreno E, Vidal-Ostos De Lara F, Enseñat J, Aznar S, Asla Q, Aviles-Pérez MD, Puig-Domingo M, Araujo-Castro M. Pituitary. 2024 Jun 28. doi: 10.1007/s11102-024-01415-x. Online ahead of print.
Cardiac MRI in acromegaly: looking for a big heart.
Schweizer JROL, Nachtigall LB.Pituitary. 2024 Jun 28. doi: 10.1007/s11102-024-01417-9. Online ahead of print.
Risk of intracranial meningioma in patients with acromegaly: a systematic review.
Guo AX, Job A, Pacione D, Agrawal N.Front Endocrinol (Lausanne). 2024 Jun 11;15:1407615. doi: 10.3389/fendo.2024.1407615. eCollection 2024.
Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.
Cho J, Kim JH, Kim YH, Lee J.Endocrinol Metab (Seoul). 2024 Jun 26. doi: 10.3803/EnM.2024.1933. Online ahead of print.
Pituitary tumor centers of excellence (PTCOE): the next border of acromegaly treatment.
Grottoli S, Ghigo E.Pituitary. 2024 Jun 25. doi: 10.1007/s11102-024-01416-w. Online ahead of print.
Pituitary Apoplexy
Pituitary apoplexy: a systematic review of non-gestational risk factors.
Kajal S, Ahmad YES, Halawi A, Gol MAK, Ashley W.Pituitary. 2024 Jun 27. doi: 10.1007/s11102-024-01412-0. Online ahead of print.
Mullins J, Bryniarski M.Cureus. 2024 May 28;16(5):e61259. doi: 10.7759/cureus.61259. eCollection 2024 May.
Hormonal Health
Evaluation and Surgical Management of Multiple Endocrine Neoplasias.
Frye CC, Brown TC, Olson JA Jr.Surg Clin North Am. 2024 Aug;104(4):909-928. doi: 10.1016/j.suc.2024.02.016. Epub 2024 Apr 4.
Identification of the FSH-RH as the other gonadotropin-releasing hormone.
Uehara SK, Nishiike Y, Maeda K, Karigo T, Kuraku S, Okubo K, Kanda S.Nat Commun. 2024 Jun 27;15(1):5342. doi: 10.1038/s41467-024-49564-8.
Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants.
Martin LJ, Touaibia M.Nutrients. 2024 Jun 9;16(12):1815. doi: 10.3390/nu16121815.
Roux A, Rosso D, Cuboni D, Maccario M, Grottoli S, Arvat E, Gasco V.Biomedicines. 2024 Jun 19;12(6):1368. doi: 10.3390/biomedicines12061368.
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