The way you think, the way you behave, the way you eat, can influence your life by 30 to 50 years.
-Deepak Chopra
PNA Spotlight: Dr. Manish Aghi
This month the PNA Spotlight focuses on Dr. Manish K. Aghi.Dr. Manish Aghi is a neurosurgeon specializing in brain tumors at UCSF Medical Center. He cares for adult patients with a wide range of conditions, including astrocytomas and anaplastic astrocytomas, oligodendrogliomas, glioblastomas, meningiomas and pituitary adenomas. As principal investigator at the UCSF Brain Tumor Research Center, his interests include glioblastoma angiogenesis, mechanisms of glioblastoma resistance to anti-angiogenic therapy and experimental glioblastoma therapies such as cancer-killing viruses.
Professor Aghi earned his medical degree and a doctoral degree in neurosciences from Harvard Medical School. He completed a residency in neurosurgery at Massachusetts General Hospital. He is a member of the Society for Neuro-Oncology, American Association of Neurological Surgeons, Congress of Neurological Surgeons and Pituitary Network Association. Among his honors are the Preuss and Mahaley awards from the American Association of Neurological Surgeons, and the Ronald L. Bittner Award, Synthes Skull Base Award and Integra Foundation Award from the Congress of Neurological Surgeons.
His answers follow.
PNA Medical Corner: Pituitary Centers of Excellence
This month the PNA Medical Corner focuses on an article co-authored by several members and colleagues of the PNA: Drs. Chanson, Kaiser, Laws, van der Lely, and Melmed. It addresses a topic that PNA has sought to promote for decades: the designation of Pituitary Centers of Excellence, where patients can get highly specialized care
Link: https://pubmed.ncbi.nlm.nih.gov/37640885/
Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers
Featured News and Updates
The FDA has approved NGENLA (somatrogon-ghla)
The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.
News Articles September 2023
Acromegalics More Likely to Have Diabetes, Cardiac Issues
An article in Healio looks at a study that found that people with acromegaly suffer at a higher rate from a long list of conditions, including diabetes and hypertension. Read more:
Isturisa Found Safe and Effective for Cushing’s
An article in Cushing’s Disease News looks at results from an extension of a study of long-term use of the drug Isturisa. It found that the drug “led to a sustained normalization in cortisol levels, symptom relief, and improved quality of life for people with Cushing’s disease.” Read more:
Study Finds Testosterone “Cliff” in Men over Age 70
An article in Cosmos looks at a study that finds that testosterone levels drop sharply after age 70; but that healthy eating and exercise can lead to more stable testosterone levels. Read more:
Girl with Growth Hormone Deficiency Chosen as “Kid Captain” for U of Iowa Football Team
Ten-year-old Gracie Springer is the new “Kid Captain” for the University of Iowa Hawkeyes football team. She suffers from growth hormone deficiency, cardiomyopathy, and is in remission from cancer. Read more:
Research Articles
September 2023 Research Articles
Pituitary Surgery
Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life.
Dexmedetomidine in Patients Undergoing Transsphenoidal Resection of Pituitary Adenoma: An Updated Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Decreasing Reimbursement of Pituitary Tumor Surgery: An Analysis of Medicare Data From 2010 to 2020.
Modified Nasoseptal Flap Technique to Prevent the Recurrence of Rathke’s Cleft Cyst.
Current and Future Perspectives of Microscopic and Endoscopic Transsphenoidal Surgery for Pituitary Adenomas: A Narrative Review.
Acromegaly
Corneal Parameters, Ocular Biometers, and Retinal and Choroidal Thickness in Acromegaly Patients.
Pituitary Biology
Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland.
Charles Bonnet syndrome in an elderly blind man with recurrent pituitary macroadenoma and optic nerve atrophy: A case report.
Imaging
MRI findings in children with migraine or tension-type headache.
Brain Tumor Detection Based on Deep Learning Approaches and Magnetic Resonance Imaging.
Hormonal Health
The association of hypogonadism with depression and its treatments.
Multiple endocrine neoplasia type 4 (MEN4): a thorough update on the latest and least known men syndrome.
Reliability of Agreement between Insulin, Clonidine, and Glucagon Stimulation Tests for the Diagnosis of Growth Hormone Deficiency in Children: A Retrospective Cohort Study.
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Disclaimer: PNA does not engage in the practice of medicine. It is not a medical authority, nor does it claim to have medical expertise. In all cases, PNA recommends that you consult your own physician regarding any course of treatment or medication.
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