The way you think, the way you behave, the way you eat, can influence your life by 30 to 50 years.

-Deepak Chopra


PNA Spotlight: Dr. Manish Aghi

This month the PNA Spotlight focuses on Dr. Manish K. Aghi.Dr. Manish Aghi is a neurosurgeon specializing in brain tumors at UCSF Medical Center. He cares for adult patients with a wide range of conditions, including astrocytomas and anaplastic astrocytomas, oligodendrogliomas, glioblastomas, meningiomas and pituitary adenomas. As principal investigator at the UCSF Brain Tumor Research Center, his interests include glioblastoma angiogenesis, mechanisms of glioblastoma resistance to anti-angiogenic therapy and experimental glioblastoma therapies such as cancer-killing viruses.
Professor Aghi earned his medical degree and a doctoral degree in neurosciences from Harvard Medical School. He completed a residency in neurosurgery at Massachusetts General Hospital. He is a member of the Society for Neuro-Oncology, American Association of Neurological Surgeons, Congress of Neurological Surgeons and Pituitary Network Association. Among his honors are the Preuss and Mahaley awards from the American Association of Neurological Surgeons, and the Ronald L. Bittner Award, Synthes Skull Base Award and Integra Foundation Award from the Congress of Neurological Surgeons.
His answers follow.

PNA Medical Corner: Pituitary Centers of Excellence

This month the PNA Medical Corner focuses on an article co-authored by several members and colleagues of the PNA: Drs. Chanson, Kaiser, Laws, van der Lely, and Melmed. It addresses a topic that PNA has sought to promote for decades: the designation of Pituitary Centers of Excellence, where patients can get highly specialized care


Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers

Featured News and Updates

The FDA has approved NGENLA (somatrogon-ghla)

The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.

See the Press Release here>

News Articles May 2024

Does a form of dwarfism improve cardiovascular risk?

A study in the Journal Med looks at the longevity of people with Laron’s Syndrome, who have low-growth hormone signaling that causes a form of dwarfism but may also confer lower risk of cancer and heart disease. Read more in the Daily Mail: or consult the original study:

Case study: Surgical Treatment of Pituitary Macroadenoma​s

A study published on looks at the case of a 48-year old woman with a pituitary macroadenoma. Surgeons removed the tumor but she suffered post-operative complications that required extensive management. They conclude that this type of surgery is complex and requires individualized care.

Acromegalic receives special-made shoes​

An article on features the story of an acromegaly patient in Venezuela who holds the record for the world’s biggest feet, according to the Guinness Book of World records. The man, named Jeison Rodriguez Hernandez, has size 26 feet and gets his shoes special-made a company in Germany. Read more:

Study: Female Cushing’s patients develop more new diseases than men after treatment

An article in Cushing’s Disease news looks at a study published in the journal Endocrinology, Diabetes & Metabolism. Researchers found that women were more likely to develop additional diseases than men, when in remission after treatment for Cushing’s syndrome. Read more:

Research Articles

May 2024 Research Articles

Pituitary Surgery

The effect of preoperative TSH levels on perioperative complications in patients undergoing pituitary surgery.

Report on Pseudoaneurysm Caused by Injury of Internal Carotid Artery During Endoscopic Pituitary Surgery and Rebleeding After Treatment With Willis Covered Stent.

Efficacy of the Craniopharyngioma Resection via Expanded Endoscopic Endonasal Transsphenoidal Approach in the Treatment of Complex Craniopharyngioma and Its Effect on Pituitary Function and Complications of Patients.

Vascular complications in craniopharyngioma-resected paediatric patients: a single-center experience.


Improvement in clinical features of hypercortisolism during osilodrostat treatment: findings from the Phase III LINC 3 trial in Cushing’s disease. 

Hormonal Health

Hypogonadotropic Hypogonadism. 

Long term pituitary function, functional- and patient reported outcomes in severe acquired brain injury. 

Panax ginseng Ameliorates Pituitary-Ovarian Dysfunction Induced by Radiofrequency Electromagnetic Radiation from Cell Phones via Upregulation of the CREM Signaling Pathway. 

Diagnosis and treatment of hypogonadism in men seeking to preserve fertility – what are the options? 

Pituitary Tumors

Rathke’s Cleft Cyst and Craniopharyngioma: A Continuum of the Same Spectrum? Insights from an Interesting Case and Previous Literature. 

Targeted therapy in BRAF mutated aggressive papillary craniopharyngioma: a case report and overview of the literature. 

Disulfiram mediated anti-tumour effect in pituitary neuroendocrine tumours by inducing cuproptosis. 

A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours. 

Immune landscape and progress in immunotherapy for pituitary neuroendocrine tumors.


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