Rarely pituitary adenomas can occur in families. If no other abnormality is associated then this condition is called Familial Isolated Pituitary Adenoma. Most often family members have acromegaly or prolactinoma, sometimes other types of adenomas.
Patients who have childhood-onset or young adult onset acromegaly have other family members with acromegaly or prolactinoma. Some of these families carry a mutation in the AIP gene.
Patients who have childhood onset acromegaly/gigantism can also carry a mutation in AIP gene even if they do not have a known family history of the disease. Please see further information and possibility to have tested at http://www.fipapatients.org.