PNA Highlights December 2022

PNA Spotlight: Dr. Christie Turin More

This month the PNA spotlight shines on Dr. Christie Turin More. Dr. More graduated from the Universidad Peruana Cayetano Heredia Facultad De Medicina Alberto Hurtado in 2013. She works in Aurora, CO and 4 other locations and specializes in Endocrinology, Diabetes & Metabolism and Internal Medicine. Dr More Interned and complete her Residency at Baylor College of Medicine. She received a Fellowship at the Hospital of the University of Pennsylvania. Dr. More answered some questions from the PNA. Here are her answers.

PNA Medical Corner: Pituitary Surgical Technique

This month the PNA Medical Corner showcases a study co-authored by three members of the PNA: Drs. Susan Samson, Kaisorn Chaichana and Alfredo Quinones-Hinojosa of the Mayo Clinic in Jacksonville, Florida. The study found that endoscopic endonasal resection of the medial wall fo the cavernous sinus is associated with better hormonal control later on, but requires advanced surgical skill. Link: https://pubmed.ncbi.nlm.nih.gov/36291288/

Endoscopic Endonasal Resection of the Medial Wall of the Cavernous Sinus and Its Impact on Outcomes of Pituitary Surgery: A Systematic Review and Meta-Analysis

Affiliations expand

Abstract:

News Articles December 2022

Pituitary Q & A

The Mayo Clinic has produced a podcast with frequently asked questions on pituitary tumors. Check it out here

Optometrist Spots Signs of Pituitary Tumor; Patient Gets Emergency Surgery

Nonmedical professionals like jewelers, shoe salespersons and optometrists can make a big impact in a patient’s life – by spotting signs of pituitary disease. An article in Insight News tells the story of an extra vigilant optometrist who spotted a red flag, and may have saved a woman’s life. Read more:

Case Study: Keto Diet Alleviates Symptoms of Cushing’s But Delays Diagnosis

An article in Cushing’s Disease News looks at a case study about a man who lost weight on a low carb ketogenic diet, which lessened his symptoms of what turned out to be Cushing’s Disease, but in doing so may have delayed his diagnosis. Read more:

TV Actor Recounts Battle With Pituitary Dwarfism

Actor Max Casella, who has co-starred in shows like “Doogie Howser, MD”,“The Sopranos”, “Boardwalk Empire” and “Tulsa King” talks about growing up with pituitary dwarfism in an article on PageSix.com. He underwent hormone therapy in his twenties to finally jumpstart puberty. Read more:

Can ‘Mini Pituitary Tumors’ Help Improve Treatments?

The website chof360.com looks at A study in the journal Cells looks at efforts by researchers to develop organoids, or organelles – basically cell structures grown in a lab using cells from pituitary surgeries. The study says these mini pituitary tumors mimic the structure of an adenoma, and thus may be useful in developing targeted therapies for Cushing’s patients. Read more:

Pituitary Tumors

Etiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents.

Kilci F, Sarikaya E, Murat NÖ, Deniz A.Endocrine. 2025 Feb 2. doi: 10.1007/s12020-025-04176-0. Online ahead of print.

Conservative medical therapy for a macroprolactinoma presenting with obstructive hydrocephalus.

Cuaño PMGM, Isip-Tan IT, Chan KIP.BMJ Case Rep. 2025 Jan 31;18(1):e261540. doi: 10.1136/bcr-2024-261540.

Individual management and prognostic assessment for long-term outcomes using a novel classification system of craniopharyngiomas: a retrospective study of single institution.

Zhang S, Xie B, He Y, Zhang X, Gong G, Li M, Chen Y, Tang G, Zhang C, Qin C, Liu Q.J Cancer Res Clin Oncol. 2025 Jan 31;151(2):57. doi: 10.1007/s00432-025-06104-1.

Mental Health and Pituitary Issues

Psychological burden in patients with sellar masses under conservative and surgical management.

Kalasauskas D, Ernst A, Mireri S, Keric N, Thavarajasingam SG, Omran W, Wüster C, Ringel F, Conrad J.Neurosurg Rev. 2025 Jan 30;48(1):104. doi: 10.1007/s10143-025-03240-7.

Social functioning longitudinal trajectory and its predictors in young and middle-aged postoperative pituitary tumor patients: A growth mixture model.

Zhou Y, Qian M, Wang S, Zhou X, Zhou M, Gu Z, Sun M, Yang T.Eur J Oncol Nurs. 2025 Jan 28;74:102815. doi: 10.1016/j.ejon.2025.102815. Online ahead of print.

Pituitary Surgery

Giant and irregular pituitary neuroendocrine tumors surgery: comparison of simultaneous combined endoscopic endonasal and transcranial and purely endoscopic endonasal surgery at a single center.

Fu J, Luo W, Zhang C, Wang Z, Fan W, Lin Y, Kang D, Song J, Jiang C, Yan X.Chin Neurosurg J. 2025 Feb 3;11(1):3. doi: 10.1186/s41016-025-00389-4.PMID: 39894800

Modified graded skull base reconstruction for intraoperative CSF leak repair in endoscopic endonasal surgeries: a single-surgeon experience in initial years of practice and nuances in the early learning curve.

Khaleghi M, Shahid AH, Suggala S, Dyess G, Hummel UN, Chason DN, Butler D, Thakur JD.Neurosurg Focus. 2025 Feb 1;58(2):E6. doi: 10.3171/2024.11.FOCUS24733.

Does the crafted abdominal fat grafting technique completely eliminate risk of postoperative CSF leak in endonasal pituitary surgery? Technical note and preliminary clinical outcome.

Lasica N, Lesha E, Beckfort NS, Arnautovic KI.Neurosurg Focus. 2025 Feb 1;58(2):E3. doi: 10.3171/2024.11.FOCUS24665.

Multicenter study on 2-year outcomes of dual application of hydroxyapatite cranioplasty and a nasoseptal flap following endoscopic endonasal surgery for tuberculum sellae meningiomas or craniopharyngiomas.

Kong DS, Kim YH, Hong SD, Ryu G, Kim JH, Hong CK, Kim YH.Neurosurg Focus. 2025 Feb 1;58(2):E2. doi: 10.3171/2024.11.FOCUS24624.

Risk Factors for Development of Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone Secretion after Transsphenoidal Resection of Pituitary Adenoma.

Petito G, Hu A, Zhang G, Min S, Tripathi SH, Kumar A, Shukla G, Shah S, Phillips KM, Jana S, Forbes JA, Zuccarello M, Andaluz NO, Sedaghat AR.J Neurol Surg B Skull Base. 2024 Feb 2;86(1):39-45. doi: 10.1055/a-2235-7419. eCollection 2025 Feb.PMID: 39881750

Cushing’s

Performance of Vasopressin Stimulated Bilateral Inferior Petrosal Sinus Sampling in Corticotropin Dependent Cushing’s Syndrome with Negative or Equivocal 3 Tesla Contrast Enhanced Magnetic Resonance Imaging of Pituitary.

Shivnani P, Kasliwal R, Goyal G, Sharma J, Balani U, Gupta P, Sharma BS, Yadav D, Mishra V, Sharma SK.Indian J Endocrinol Metab. 2024 Nov-Dec;28(6):589-595. doi: 10.4103/ijem.ijem_60_24. Epub 2024 Dec 30.

Hormonal health

The hypothalamus and pituitary gland regulate reproduction and are involved in the development of polycystic ovary syndrome.

Long BY, Liao X, Liang X.Neuroendocrinology. 2025 Jan 31:1-26. doi: 10.1159/000543877. Online ahead of print.

Cabergoline-induced NDFIP1 upregulation in pituitary neuroendocrine tumor cells activates mTOR signaling and contributes to cabergoline resistance.

Gu W, Zhang W, Wu Z, Cai Y.J Neurooncol. 2025 Feb 1. doi: 10.1007/s11060-025-04949-7. Online ahead of print.