“Give a man health and a course to steer, and he’ll never stop to trouble about whether he’s happy or not.”

– George Bernard Shaw

 

PNA Spotlight: Dr. Paul A. Gardner

This month the PNA Spotlight focuses on Dr. Paul A. Gardner. 

Paul A. Gardner, MD, joined the faculty at the University of Pittsburgh Department of Neurological Surgery in 2008 after completing his residency and fellowship training at the University of Pittsburgh. He completed his undergraduate studies at Florida State University, majoring in biochemistry, and received his medical degree from the University of Pittsburgh School of Medicine.

Dr. Gardner completed a two-year fellowship in endoscopic endonasal pituitary and endoscopic and open skull base surgery. His research has focused on evaluating patient outcomes following these surgeries and more recently on genomic and molecular analysis of skull base tumors. Dr. Gardner has been the neurosurgical director of the Center for Cranial Base Surgery at the University of Pittsburgh Medical Center since April of 2008 and, along with Carl Snyderman, MD, of the University of Pittsburgh Department of Ophthalmology, leads a renowned course on endoscopic endonasal surgery three times a year.

His answers are below:

PNA Medical Corner: Artificial intelligence and pituitary surgery

The PNA Medical Corner this month features an article co-authored by neurosurgeon Aaron Cohen-Gadol of Indiana University, a longtime member of the PNA. They conclude that A-I and machine learning will improve preoperative planning and surgical strategies in pituitary surgery, but points out challenges on multiple fronts.

Current status of artificial intelligence technologies in pituitary adenoma surgery: a scoping review

Abstract

Purpose: Pituitary adenoma surgery is a complex procedure due to critical adjacent neurovascular structures, variations in size and extensions of the lesions, and potential hormonal imbalances. The integration of artificial intelligence (AI) and machine learning (ML) has demonstrated considerable potential in assisting neurosurgeons in decision-making, optimizing surgical outcomes, and providing real-time feedback.

    Featured News and Updates

    News Articles June 2026

    Woman diagnosed with both Cushing’s Disease and Syndrome

    An study in Cureus details the rare case of a Moroccan woman diagnosed with both Cushing’s Disease and Cushing’s Syndrome.  She had been self-medicating with dexamethasone. Read more: https://www.cureus.com/articles/494214-is-it-possible-to-have-coexisting-exogenous-and-endogenous-cushings-syndrome#!/

    Real Housewife, former beauty queen tells her pituitary story

    Kelsey Swanson, a cast member of Real Housewives of Rhode Island and a former Miss Rhode Island discusses her battle with a pituitary tumor in an article in Yahoo.com. Read more: https://www.yahoo.com/entertainment/tv/articles/breaking-down-rhori-kelsey-swanson-150326808.html

    Study links radiotherapy to increased mortality in pituitary patients

    An article in Medscape looks at a study on radiotherapy in patients with pituitary tumors and found increased mortality rates. Read more: https://www.medscape.com/viewarticle/increased-mortality-after-radiotherapy-pituitary-adenoma-2026a1000gmy

    Pituitary mass mistaken for migraine in expectant mother

    An article in the Times of India explains the case of a pregnant woman with debilitating headaches and vision loss. Doctors initially thought she had migraines, when it turned out to be a suprasellar mass. Read more: https://timesofindia.indiatimes.com/health/severe-headache-during-pregnancy-turned-out-to-be-a-1-in-9-million-pituitary-disorder-after-symptoms-were-mistaken-for-migraine/articleshow/131293833.cms

     

     

    Research Articles

    Research Articles June 2026

    Pituitary Tumors


    Pituitary adenomas associated with hydrocephalus: clinical characteristics, risk stratification, and clinical management.

    Zhou W, Yu M, Cheng S, Zhu H, Cao L, Li Z, Liu C, Bai J, Zhao P, Zhang Y, Gui S, Li C.J Neurooncol. 2026 May 29;178(1):31. doi: 10.1007/s11060-026-05653-w.

    Organoids as next-generation models for investigating intracranial tumours.

    Roy S, Zahin F, Nkrumah-Boateng PA, Chaudhry S, Nassor M, Kwarteng MFA, Owusu-Boampong AB, Wireko AA.Mol Brain. 2026 May 30. doi: 10.1186/s13041-026-01317-y. Online ahead of print.PMID: 42218467 Review.

    Enhancing brain tumor classification with a simplified CNN through hyperparameter optimization.

    Remzan N, Tahiry K, Farchi A, Arbi A.Biomed Phys Eng Express. 2026 May 29. doi: 10.1088/2057-1976/ae74d5. Online ahead of print.PMID: 42214387

    LAT1-mediated amino acid metabolism reprogramming: a novel metabolic vulnerability in recurrent pituitary neuroendocrine tumors.

    Pei ZJ, Li GW, Yu JH, Yang HR, Fang Y, Zhou LX.Endocr Connect. 2026 May 29:EC-25-0860. doi: 10.1530/EC-25-0860. Online ahead of print.


    Osteometabolic complications in patients with secreting pituitary adenomas: Is there an impact of gender?

    di Filippo L, Acanfora M, Bolamperti S, Terenzi U, Bonomo M, Giustina A.Pituitary. 2026 May 29;29(3):96. doi: 10.1007/s11102-026-01667-9.


    The hook effect in macroprolactinomas: tumor size thresholds, prolactin patterns, and clinical consequences – a systematic review.

    Yadav P, Hamrahian AH, Salvatori R.Pituitary. 2026 May 29;29(3):98. doi: 10.1007/s11102-026-01705-6.

     

    Pituitary Surgery


    Systematic anatomical validation of the endoscopic mononostril transethmoid-paraseptal approach to the central skull base.

    Eördögh M, Weidemeier M, Baksa G, Patonay L, Simmen D, Schroeder HWS, El Refaee E, Hosemann W, Reisch R, Briner HR.Brain Spine. 2026 May 15;6:106092. doi: 10.1016/j.bas.2026.106092. eCollection 2026.

     

    Pituitary apoplexy

    Management-specific outcome evaluation of pituitary apoplexy; conservative and surgical approach.

    Guijt MC, Verstegen MJT, Zamanipoor Najafabadi AH, Bakker LEH, Notting IC, Pelsma ICM, van Furth WR, Biermasz NR, Claessen KMJA.Pituitary. 2026 May 29;29(3):97. doi: 10.1007/s11102-026-01695-5.

     

    Acromegaly

    Speckle-tracking echocardiography reveals the synergistic impact of GH/IGF-1 excess and metabolic dysregulation on cardiac dysfunction in acromegaly.

    Chen M, Zhang P, He W, Jin J, Huang R, Liao Z, Xiao H, Yao F, Li Y, Li H.Pituitary. 2026 May 29;29(3):95. doi: 10.1007/s11102-026-01684-8.

     

    Cushing’s disease

    Real-Time PCR-Based Intraoperative Molecular Boundary Diagnosis of Corticotroph Pituitary Neuroendocrine Tumors.

    Sato Y, Takeuchi K, Ohka F, Nagata Y, Maeda S, Matsuyama T, Hirose T, Deguchi S, Okumura E, Iwami K, Saito R.J Neurosci Methods. 2026 May 28:110814. doi: 10.1016/j.jneumeth.2026.110814. Online ahead of print.PMID: 42214473

     

    Hyperprolactinemia


    Transient Hyperprolactinemia Associated With Semaglutide in a Patient With Hashimoto’s Thyroiditis.

    Guimarães GNF.Case Rep Med. 2026 May 27;2026:3016596. doi: 10.1155/carm/3016596. eCollection 2026.

     

    Hormonal Health

    Genetic Insights Into AVP Deficiency: Identification of a Novel AVP Variant and Compilation of a Curated Catalogue of Pathogenic Variants.

    Joseph J, Søndergaard E, Knorr S, Knudsen JH, Rittig S, Christensen JH.Clin Genet. 2026 May 29. doi: 10.1111/cge.70183. Online ahead of print.

     

     

    The FDA has approved NGENLA (somatrogon-ghla)

    The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.

    See the Press Release here>

    Count on your Xeris CareConnection™ Team for unparalleled Cushing’s Support

    Cushing’s can be challenging, but there is support so patients can feel like themselves again. The main goal of treating Cushing’s is to get cortisol levels back to normal. This Pituitary Awareness Month, Xeris Pharmaceuticals® is highlighting the importance of one-on-one support for patients living with Cushing’s Syndrome and support for HCPs treating Cushing’s Syndrome.

    Sign up to get dedicated support:

    Patients: Sign up for support | Recorlev® (levoketoconazole)

    HCP’s: Connect with Xeris support | RECORLEV® (levoketoconazole)

    Have more questions? Call for more support at 1-844-444-RCLV (7258)

    Copyright © 2024 Pituitary Network Association All rights reserved.

    Disclaimer: PNA does not engage in the practice of medicine. It is not a medical authority, nor does it claim to have medical expertise. In all cases, PNA recommends that you consult your own physician regarding any course of treatment or medication.

    Our mailing address is:
    Pituitary Network Association
    P.O. Box 1958
    Thousand Oaks, CA 91358
    (805) 499-9973 Phone - (805) 480-0633 Fax
    Email [email protected]

    You are receiving this Newsletter because you have shown interest in receiving information about our activities.

    If you do not want to receive any more emails from PNA, Unsubscribe.