“Give a man health and a course to steer, and he’ll never stop to trouble about whether he’s happy or not.”

– George Bernard Shaw

 

PNA Spotlight: Dr. Paul A. Gardner

This month the PNA Spotlight focuses on Dr. Paul A. Gardner. 

Paul A. Gardner, MD, joined the faculty at the University of Pittsburgh Department of Neurological Surgery in 2008 after completing his residency and fellowship training at the University of Pittsburgh. He completed his undergraduate studies at Florida State University, majoring in biochemistry, and received his medical degree from the University of Pittsburgh School of Medicine.

Dr. Gardner completed a two-year fellowship in endoscopic endonasal pituitary and endoscopic and open skull base surgery. His research has focused on evaluating patient outcomes following these surgeries and more recently on genomic and molecular analysis of skull base tumors. Dr. Gardner has been the neurosurgical director of the Center for Cranial Base Surgery at the University of Pittsburgh Medical Center since April of 2008 and, along with Carl Snyderman, MD, of the University of Pittsburgh Department of Ophthalmology, leads a renowned course on endoscopic endonasal surgery three times a year.

His answers are below:

PNA Medical Corner: Artificial intelligence and pituitary surgery

The PNA Medical Corner this month features an article co-authored by neurosurgeon Aaron Cohen-Gadol of Indiana University, a longtime member of the PNA. They conclude that A-I and machine learning will improve preoperative planning and surgical strategies in pituitary surgery, but points out challenges on multiple fronts.

Current status of artificial intelligence technologies in pituitary adenoma surgery: a scoping review

Abstract

Purpose: Pituitary adenoma surgery is a complex procedure due to critical adjacent neurovascular structures, variations in size and extensions of the lesions, and potential hormonal imbalances. The integration of artificial intelligence (AI) and machine learning (ML) has demonstrated considerable potential in assisting neurosurgeons in decision-making, optimizing surgical outcomes, and providing real-time feedback.

    Featured News and Updates

    News Articles July 2026

    Infant diagnosed with pituitary tumor

    Doctors in the U.K. diagnosed a 4-month-old baby boy with a pituitary tumor and performed surgery to remove it. Read more: https://uk.news.yahoo.com/bradford-baby-diagnosed-brain-tumour-020000577.html

    Pituitary journey: Soccer superstar Lionel Messi

    A doctor in the U.K. well-known for his internet explainer videos explains on the case of soccer star Lionel Messi, who was diagnosed with growth hormone deficiency as a child and underwent years of growth hormone injections. His family paid for the medical care at first but then Team Barcelona agreed to cover the cost of his treatment in Spain.  See the YouTube video here: https://www.youtube.com/watch?v=Liovxj7D0H4

    Pituitary journey: from patient to future neurosurgeon

    An article on The Good Things Guy website looks at the pituitary journey of Cadi de Jager, a 19-year-old woman in South Africa who was diagnosed at age nine with a Rathke’s Cleft cyst. She underwent two surgeries and is now in college with the goal of becoming a pediatric neurosurgeon. Read more: https://www.goodthingsguy.com/cadi-de-jager-conquered-brain-tumour/

    Sprained ankle leads to Cushing’s diagnosis

    A teen in Brazil with a sprained ankle went to the ER – where alert doctors decided to test him for Cushing’s disease after hearing about his sudden weight gain, headaches and high blood pressure. Read more:  https://en.clickpetroleoegas.com.br/teens-weight-gain-and-cushings-disease-revealed-by-ankle-injury-doctors-discover-tiny-pituitary-tumor-in-113-kilo-brazilian-adolescent-vacs75/#goog_rewarded

    Research Articles

    Research Articles July 2026

    Pituitary tumors

    Pituitary adenoma-associated with Schopf-Schulz-Passarge syndrome.

    Brady RT, Allinson K, René C.BMJ Case Rep. 2026 Jun 26;19(6):e267144. doi: 10.1136/bcr-2025-267144.

     

    Immune and clinicopathological features of molecularly defined prolactinoma subtypes.

    Wang DP, Liu YT, Dai YT, Chen S, Cheng YJ, Lin SJ, Zhang Y, Xue L, Xie J, Wu ZB.J Neurosurg. 2026 Jun 26:1-11. doi: 10.3171/2026.1.JNS251768. Online ahead of print.


    Repurposing the Antibiotic Tigecycline to Inhibit Tumor Growth and Hormone Secretion in Somatotroph Pituitary Neuroendocrine Tumors.

    Yang Z, Liu Y, Wu D, Xu B, Zeng S, Zhang W.Int J Endocrinol. 2026 Jun 24;2026:3784550. doi: 10.1155/ije/3784550. eCollection 2026.


    An Explainable Multi-Scale Deep Learning Framework for Multi-Class Brain MRI Classification.

    Alshammari HH, Mahmood MA.Diagnostics (Basel). 2026 Jun 10;16(12):1791. doi: 10.3390/diagnostics16121791.

     

    Clinical Features and Key Prognostic Indicators of Growth Hormone-Secreting Pituitary Adenomas: A Retrospective Study of 344 Cases.

    Zhang Y, Mi Z, Wu H, Ma X, Xi L, Yang Z, Liu P.Curr Oncol. 2026 May 27;33(6):310. doi: 10.3390/curroncol33060310.

     

    Pituitary Tumors in Maxillofacial Radiology and Daily Practice: A Scoping Review.

    Stucki L, Mauer U, Kildal D, Rózsa NK, Geibel MA.Dent J (Basel). 2026 Jun 15;14(6):368. doi: 10.3390/dj14060368.

     

    Radiomics for Preoperative Assessment of Pituitary Adenoma Consistency with T2-Weighted MRI: A Multicenter Study.

    Agosti E, Cuocolo R, Mangili M, Rampinelli V, Veiceschi P, Cappelletti M, Panciani PP, Piazza A, Bove I, Solari D, Cavallo LM, Locatelli D, Doglietto F, Fiorindi A, Fontanella MM, Ugga L.J Neurol Surg B Skull Base. 2025 Jun 4;87(3):314-321. doi: 10.1055/a-2607-0735. eCollection 2026 Jun.

     

    Acromegaly

    Safety and Efficacy of Once-Daily Oral Paltusotine in Acromegaly: ACROBAT Advance Open-Label Extension Up to 4 Years.

    Gadelha MR, Gordon MB, Doknic M, Mezősi E, Tóth M, Randeva H, Boguszewski CL, Davidson C, Casagrande A, Jochelson T, Krasner A.J Clin Endocrinol Metab. 2026 Jun 26:dgag254. doi: 10.1210/clinem/dgag254. Online ahead of print.

     

    Cushing’s

    Twenty years of neurosurgical experience with Cushing’s disease: surgical-strategies, endocrine outcomes and remission predictors in 346 patients.

    Honegger J, Grimm F, Gött H, Nasi-Kordhishti I.Eur J Endocrinol. 2026 Jun 26:lvag115. doi: 10.1093/ejendo/lvag115. Online ahead of print.


    Catheterization of the petrosal sinus: possible advantage of desmopressin stimulation in Cushing disease.

    Garmes HM, Siqueira SC, Daniel KB, Trentin MBF, Fujiwara MT, Schinoll C, Fabbro MD, Rogerio F, Deus-Silva L, Reis F.Arch Endocrinol Metab. 2026 Jun 25;70(4):e260064. doi: 10.20945/2359-4292-2026-0064.

     

    Pituitary apoplexy

    Activated Macrophages Promote TNF-alpha-Associated Tumor Cell Necroptosis in Pituitary Apoplexy Through the PIEZO1-NFATC2/REL Axis.

    Li X, Zhou L, Lei Z, Li S, Wang Q, Zhao H, Xu L, Chen J, Wan X, Huang Y, Lei T.Int J Mol Sci. 2026 Jun 22;27(12):5635. doi: 10.3390/ijms27125635.

     

    Pituitary cancer

    Beyond the Usual: Breast, Pituitary and Gastric Metastases from Clear Cell Renal Cell Carcinomas-A Case Series with Review of Literature.

    Wong YP, Khairuddin NL, Thanabalan J, Tan GC.Diagnostics (Basel). 2026 Jun 9;16(12):1773. doi: 10.3390/diagnostics16121773.

     

    Pituitary Metastasis in Lung Cancer Patients: Case Series and Review of the Literature.

    Ntouraki S, Roumpou A, Asimakopoulou A, Gkiozos I, Sarropoulou F, Mani M, Marioli A, Bouklas D, Syrigos K, Peppa M.Curr Oncol. 2026 Jun 16;33(6):362. doi: 10.3390/curroncol33060362.

     

    Hormonal Health

    Salivary Cortisol Response After Ropivacaine-Dexamethasone Administration: A Randomized Clinical Trial.

    Stojanović SM, Burić NB, Kostić MS, Burić KN, Stojković BB, Spasić MS, Tijanić M, Trajković M, Jovanović R, Petrović MS.Pharmaceuticals (Basel). 2026 Jun 12;19(6):930. doi: 10.3390/ph19060930.

     

    The Global Decline in Sperm Count and Testosterone Levels: Trends, Mechanisms, and Environmental Drivers.

    La Vignera S, Condorelli RA.Antioxidants (Basel). 2026 Jun 22;15(6):778. doi: 10.3390/antiox15060778.

     

    Microplastics as trojan horses: A new perspective on bisphenol toxicity in male infertility and assisted reproduction.

    Marraschi GK, Vitale OG, Kassuya CAL, Jorge BC, Arena AC.Reprod Toxicol. 2026 Jun 25:109298. doi: 10.1016/j.reprotox.2026.109298. Online ahead of print.

    The FDA has approved NGENLA (somatrogon-ghla)

    The FDA has approved NGENLA (somatrogon-ghla), a once-weekly, human growth hormone analog indicated for treatment of pediatric patients aged three years and older who have growth failure due to an inadequate secretion of endogenous growth hormone.

    See the Press Release here>

    Count on your Xeris CareConnection™ Team for unparalleled Cushing’s Support

    Cushing’s can be challenging, but there is support so patients can feel like themselves again. The main goal of treating Cushing’s is to get cortisol levels back to normal. This Pituitary Awareness Month, Xeris Pharmaceuticals® is highlighting the importance of one-on-one support for patients living with Cushing’s Syndrome and support for HCPs treating Cushing’s Syndrome.

    Sign up to get dedicated support:

    Patients: Sign up for support | Recorlev® (levoketoconazole)

    HCP’s: Connect with Xeris support | RECORLEV® (levoketoconazole)

    Have more questions? Call for more support at 1-844-444-RCLV (7258)

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